{"id":"https://openalex.org/W2015053293","doi":"https://doi.org/10.1159/000196235","title":"Pulmonary Emphysema followed by Pulmonary Fibrosis of Undetermined Cause","display_name":"Pulmonary Emphysema followed by Pulmonary Fibrosis of Undetermined Cause","publication_year":2009,"publication_date":"2009-01-20","ids":{"openalex":"https://openalex.org/W2015053293","doi":"https://doi.org/10.1159/000196235","mag":"2015053293","pmid":"https://pubmed.ncbi.nlm.nih.gov/8290801"},"language":"en","primary_location":{"id":"doi:10.1159/000196235","doi":"https://doi.org/10.1159/000196235","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000196235","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074509542","display_name":"Nanako Hiwatari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nanako Hiwatari","raw_affiliation_strings":["First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113600162","display_name":"Sanae Shimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sanae Shimura","raw_affiliation_strings":["First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110768551","display_name":"Tamotsu Takishima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamotsu Takishima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9268,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.93355853,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"6","first_page":"354","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9940000176429749},{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.746999979019165},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5600000023841858},{"id":"https://openalex.org/keywords/common-pathogenesis","display_name":"common pathogenesis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"chronic infection","score":0.3019999861717224},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9390518665313721},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.7669147253036499},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.7208102941513062},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6687740087509155},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6680527925491333},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5838627219200134},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.514891505241394},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5137244462966919},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.44007280468940735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4209189713001251},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.4176478981971741},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39379632472991943}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000196235","doi":"https://doi.org/10.1159/000196235","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000196235","pdf_url":null,"source":{"id":"https://openalex.org/S121535265","display_name":"Respiration","issn_l":"0025-7931","issn":["0025-7931","1423-0356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration","raw_type":"journal-article"},{"id":"pmid:8290801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8290801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiration; international review of thoracic diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2913338666","https://openalex.org/W2123670242","https://openalex.org/W1484425423","https://openalex.org/W2071570110","https://openalex.org/W2507408944","https://openalex.org/W2069415543","https://openalex.org/W2073296429","https://openalex.org/W2116863551","https://openalex.org/W4387248217","https://openalex.org/W2464504693"],"abstract_inverted_index":{"Idiopathic":[0],"pulmonary":[1,5,186,198,225],"fibrosis":[2,199,226],"(IPF)":[3],"and":[4,11,14,93,96,103,114,121,133,141,170,200,212,224],"emphysema":[6,223],"(PE)":[7],"have":[8,15,26,36],"distinct":[9],"clinical":[10,45,159],"pathological":[12,151,213],"characteristics,":[13],"been":[16,116],"considered":[17],"to":[18,31,79,158,181],"be":[19],"separate":[20],"disorders.":[21],"However,":[22,41],"recent":[23],"animal":[24],"experiments":[25],"suggested":[27],"that,":[28],"with":[29],"regard":[30],"their":[32],"pathogenesis,":[33],"the":[34,84,124,144,150,167,173,188,220,234],"diseases":[35,236],"some":[37],"features":[38],"in":[39,143,156,166,172,179,195,227],"common.":[40],"there":[42],"are":[43,237],"no":[44],"data":[46],"supporting":[47],"this":[48,112],"hypothesis.":[49],"We":[50],"report":[51],"here":[52],"9":[53],"patients":[54,76,90,98,108,146,162],"(all":[55],"male,":[56],"67":[57],"+/-":[58,62],"2":[59,97],"years,":[60],"mean":[61],"SE)":[63],"who":[64,77],"had":[65,100,115],"PE":[66,75,122,142,164,196],"followed":[67],"by":[68,123,209,239],"IPF.":[69],"They":[70],"were":[71,91,109,206],"found":[72],"among":[73],"152":[74],"came":[78],"Tohoku":[80],"University":[81],"Hospital":[82],"during":[83,111],"past":[85],"15":[86],"years":[87],"(1976-1991).":[88],"All":[89,161],"male":[92],"heavy":[94],"smokers":[95],"also":[99],"prostate":[101],"cancer":[102],"gastric":[104],"cancer,":[105],"respectively.":[106],"Three":[107],"alive":[110],"study":[113],"diagnosed":[117],"as":[118],"having":[119],"IPF":[120,140,171,202],"combination":[125],"of":[126,139,153,185,222],"transbronchial":[127],"biopsy,":[128],"selective":[129],"alveolobronchogram,":[130],"CT":[131],"examination":[132],"lung":[134],"function":[135],"tests.":[136],"The":[137],"diagnosis":[138],"other":[145],"was":[147],"based":[148],"on":[149],"findings":[152],"autopsied":[154],"lungs":[155],"addition":[157,180],"findings.":[160,214],"showed":[163],"mainly":[165],"upper":[168],"lobes":[169],"lower":[174],"lobes.":[175],"In":[176],"all":[177,182],"patients,":[178],"known":[183],"causes":[184],"fibrosis,":[187],"possibilities":[189],"that":[190,201],"chronic":[191],"or":[192,232],"recurrent":[193],"infections":[194],"induced":[197],"produced":[203],"emphysematous":[204],"changes":[205],"carefully":[207],"excluded":[208],"medical":[210],"records":[211],"It":[215],"is":[216,230],"not":[217],"clear":[218],"whether":[219,233],"occurrence":[221],"these":[228],"cases":[229],"coincidental,":[231],"two":[235],"linked":[238],"a":[240],"common":[241],"pathogenetic":[242],"pathway.":[243]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}