{"id":"https://openalex.org/W2015052584","doi":"https://doi.org/10.1371/journal.pone.0061856","title":"Extracellular Matrix Aggregates from Differentiating Embryoid Bodies as a Scaffold to Support ESC Proliferation and Differentiation","display_name":"Extracellular Matrix Aggregates from Differentiating Embryoid Bodies as a Scaffold to Support ESC Proliferation and Differentiation","publication_year":2013,"publication_date":"2013-04-18","ids":{"openalex":"https://openalex.org/W2015052584","doi":"https://doi.org/10.1371/journal.pone.0061856","mag":"2015052584","pmid":"https://pubmed.ncbi.nlm.nih.gov/23637919","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630218"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0061856","doi":"https://doi.org/10.1371/journal.pone.0061856","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061856","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061856&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061856&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111657676","display_name":"Saik-Kia Goh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saik-Kia Goh","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018383397","display_name":"Phillip Olsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Olsen","raw_affiliation_strings":["Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087175427","display_name":"Ipsita Banerjee","orcid":"https://orcid.org/0000-0001-6791-3646","observed_orcids":["https://orcid.org/0000-0001-6791-3646"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ipsita Banerjee","raw_affiliation_strings":["Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087175427"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.2561,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.95421632,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"e61856","last_page":"e61856"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8970000147819519},{"id":"https://openalex.org/keywords/decellularization","display_name":"decellularization","score":0.7770000100135803},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.9860000014305115},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.8830000162124634},{"id":"https://openalex.org/keywords/spontaneous-differentiation","display_name":"spontaneous differentiation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cell-seeding","display_name":"cell seeding","score":0.5740000009536743},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cell-attachment","display_name":"cell attachment","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.9066433906555176},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8290084600448608},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.7488171458244324},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7177964448928833},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5808940529823303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5691208243370056},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5455349087715149},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5284599661827087},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4748968183994293},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46509280800819397},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.42635589838027954},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.422929584980011},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.4138648211956024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30933046340942383},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.17361828684806824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1495860517024994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05831533670425415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D058732","descriptor_name":"Embryoid Bodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0061856","doi":"https://doi.org/10.1371/journal.pone.0061856","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061856","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061856&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2640471","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3630218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3630218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23637919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23637919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:d-scholarship.pitt.edu:18639","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18639/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.798.8930","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.798.8930","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/73/2b/pone.0061856.PMC3630218.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.951.7759","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.951.7759","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://d-scholarship.pitt.edu/18639/1/Extracellular_Matrix_Aggregates_from_Differentiating.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:94749d556f124266871cc5e944a198f1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/94749d556f124266871cc5e944a198f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 4, p e61856 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/685646","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Extracellular_Matrix_Aggregates_from_Differentiating_Embryoid_Bodies_as_a_Scaffold_to_Support_ESC_Proliferation_and_Differentiation_/685646","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0061856","doi":"https://doi.org/10.1371/journal.pone.0061856","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0061856","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061856&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4974882718","display_name":null,"funder_award_id":"DP2-116520","funder_id":"https://openalex.org/F4320337383","funder_display_name":"National Center for Chronic Disease Prevention and Health Promotion"},{"id":"https://openalex.org/G5664278136","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1TR000005","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8888332230","display_name":null,"funder_award_id":"DP2 116520","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308963","display_name":"Oak Ridge Associated Universities","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337383","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015052584.pdf","grobid_xml":"https://content.openalex.org/works/W2015052584.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1603508604","https://openalex.org/W1922106993","https://openalex.org/W1948275303","https://openalex.org/W1964083927","https://openalex.org/W1965215772","https://openalex.org/W1965221772","https://openalex.org/W1968649970","https://openalex.org/W1974452230","https://openalex.org/W1978993910","https://openalex.org/W1983829588","https://openalex.org/W1987602789","https://openalex.org/W1990574061","https://openalex.org/W1990683187","https://openalex.org/W1991817888","https://openalex.org/W1993754110","https://openalex.org/W1999459866","https://openalex.org/W1999574290","https://openalex.org/W2004550343","https://openalex.org/W2007418429","https://openalex.org/W2011543364","https://openalex.org/W2012204820","https://openalex.org/W2012230887","https://openalex.org/W2013657120","https://openalex.org/W2014726972","https://openalex.org/W2022797781","https://openalex.org/W2032965689","https://openalex.org/W2034356218","https://openalex.org/W2036279456","https://openalex.org/W2037550327","https://openalex.org/W2037810763","https://openalex.org/W2038226174","https://openalex.org/W2039756909","https://openalex.org/W2041180426","https://openalex.org/W2041726020","https://openalex.org/W2042485268","https://openalex.org/W2043007061","https://openalex.org/W2043800986","https://openalex.org/W2044151683","https://openalex.org/W2047298301","https://openalex.org/W2051021067","https://openalex.org/W2052047776","https://openalex.org/W2052598541","https://openalex.org/W2058763271","https://openalex.org/W2059486645","https://openalex.org/W2068311284","https://openalex.org/W2071071731","https://openalex.org/W2071359561","https://openalex.org/W2072292497","https://openalex.org/W2075187155","https://openalex.org/W2083940756","https://openalex.org/W2093134227","https://openalex.org/W2093452639","https://openalex.org/W2101228997","https://openalex.org/W2111338636","https://openalex.org/W2111888351","https://openalex.org/W2123907013","https://openalex.org/W2130255071","https://openalex.org/W2132669667","https://openalex.org/W2146423069","https://openalex.org/W2165617122","https://openalex.org/W2169980572","https://openalex.org/W2320805654","https://openalex.org/W4230240787"],"related_works":["https://openalex.org/W2003984619","https://openalex.org/W2091380345","https://openalex.org/W1991817888","https://openalex.org/W1646577443","https://openalex.org/W3013565710","https://openalex.org/W2617285926","https://openalex.org/W2086702591","https://openalex.org/W2047298301","https://openalex.org/W2737984947","https://openalex.org/W7095831147"],"abstract_inverted_index":{"Embryonic":[0],"stem":[1,52],"cells":[2,89,184],"(ESCs)":[3],"have":[4],"emerged":[5],"as":[6,106,130],"potential":[7,24],"cell":[8,31,53,165],"sources":[9],"for":[10,204,245],"tissue":[11,246],"engineering":[12],"and":[13,22,55,73,81,125,132,148,168,189,209,216,243],"regeneration":[14,247],"owing":[15],"to":[16,25,50,77,90,120,199,213,237],"its":[17],"virtually":[18],"unlimited":[19],"replicative":[20],"capacity":[21],"the":[23,46,60,111,169,179,230],"differentiate":[26],"into":[27],"a":[28,107,163,200],"variety":[29],"of":[30,62,114,171,232],"types.":[32],"Current":[33],"differentiation":[34,56,244],"strategies":[35],"primarily":[36],"involve":[37],"various":[38,226],"growth":[39],"factor/inducer/repressor":[40],"concoctions":[41],"with":[42,87,159],"less":[43],"emphasis":[44],"on":[45],"substrate.":[47],"Developing":[48],"biomaterials":[49],"promote":[51],"proliferation":[54,242],"could":[57],"aid":[58],"in":[59,116],"realization":[61],"this":[63,96,138],"goal.":[64],"Extracellular":[65],"matrix":[66],"(ECM)":[67],"components":[68],"are":[69,150],"important":[70],"physiological":[71],"regulators,":[72],"can":[74],"provide":[75],"cues":[76],"direct":[78],"ESC":[79,99,206,239],"expansion":[80],"differentiation.":[82],"ECM":[83,115,140,155,188,193,218],"undergoes":[84],"constant":[85],"remodeling":[86],"surrounding":[88],"accommodate":[91],"specific":[92],"developmental":[93],"event.":[94],"In":[95],"study,":[97],"using":[98,162],"derived":[100,235],"aggregates":[101],"called":[102],"embryoid":[103],"bodies":[104],"(EB)":[105],"model,":[108],"we":[109,136],"characterized":[110],"biological":[112],"nature":[113],"EB":[117,154,196,215],"after":[118],"exposure":[119],"different":[121],"treatments:":[122],"spontaneously":[123],"differentiated":[124],"retinoic":[126],"acid":[127],"treated":[128],"(denoted":[129],"SPT":[131,195],"RA,":[133],"respectively).":[134],"Next,":[135],"extracted":[137],"treatment-specific":[139],"by":[141],"detergent":[142],"decellularization":[143],"methods":[144],"(Triton":[145],"X-100,":[146],"DOC":[147],"SDS":[149],"compared).":[151],"The":[152],"resulting":[153],"scaffolds":[156,236],"were":[157],"seeded":[158],"undifferentiated":[160],"ESCs":[161,172],"novel":[164],"seeding":[166],"strategy,":[167],"behavior":[170],"was":[173],"studied.":[174],"Our":[175],"results":[176],"showed":[177],"that":[178,225],"optimized":[180],"protocol":[181],"efficiently":[182],"removes":[183],"while":[185],"retaining":[186],"crucial":[187],"biochemical":[190],"components.":[191],"Decellularized":[192],"from":[194,219],"gave":[197],"rise":[198],"more":[201],"favorable":[202],"microenvironment":[203],"promoting":[205],"attachment,":[207],"proliferation,":[208],"early":[210],"differentiation,":[211],"compared":[212],"native":[214],"decellularized":[217],"RA":[220],"EB.":[221],"These":[222],"findings":[223],"suggest":[224],"treatment":[227],"conditions":[228],"allow":[229],"formulation":[231],"unique":[233],"ESC-ECM":[234],"enhance":[238],"bioactivities,":[240],"including":[241],"applications.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
