{"id":"https://openalex.org/W2015047638","doi":"https://doi.org/10.1021/ja511609u","title":"Dependence of Internal Friction on Folding Mechanism","display_name":"Dependence of Internal Friction on Folding Mechanism","publication_year":2015,"publication_date":"2015-02-27","ids":{"openalex":"https://openalex.org/W2015047638","doi":"https://doi.org/10.1021/ja511609u","mag":"2015047638","pmid":"https://pubmed.ncbi.nlm.nih.gov/25721133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4379956"},"language":"en","primary_location":{"id":"doi:10.1021/ja511609u","doi":"https://doi.org/10.1021/ja511609u","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja511609u","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/ja511609u","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061537503","display_name":"Wenwei Zheng","orcid":"https://orcid.org/0000-0002-9603-009X","observed_orcids":["https://orcid.org/0000-0002-9603-009X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenwei Zheng","raw_affiliation_strings":["National Institutes of Health , , , ,","Laboratory of Chemical Physics, National institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health , , , ,","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory of Chemical Physics, National institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054817549","display_name":"David De Sancho","orcid":"https://orcid.org/0000-0002-8985-2685","observed_orcids":["https://orcid.org/0000-0002-8985-2685"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210117190","display_name":"CIC nanoGUNE","ror":"https://ror.org/023ke8y90","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210117190"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"David De Sancho","raw_affiliation_strings":["CIC nanoGUNE , ,","IKERBASQUE, Basque Foundation for Science , Maria Diaz de Haro 3 , ,","University of Cambridge , , Lensfield Road , ,","Department#R#of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIC nanoGUNE , ,","institution_ids":["https://openalex.org/I4210117190"]},{"raw_affiliation_string":"IKERBASQUE, Basque Foundation for Science , Maria Diaz de Haro 3 , ,","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"University of Cambridge , , Lensfield Road , ,","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department#R#of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047194086","display_name":"Travis A. Hoppe","orcid":"https://orcid.org/0000-0002-4694-3050","observed_orcids":["https://orcid.org/0000-0002-4694-3050"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis Hoppe","raw_affiliation_strings":["National Institutes of Health , , , ,","Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health , , , ,","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059620610","display_name":"Robert B. Best","orcid":"https://orcid.org/0000-0002-7893-3543","observed_orcids":["https://orcid.org/0000-0002-7893-3543"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert B. Best","raw_affiliation_strings":["National Institutes of Health , , , ,","Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health , , , ,","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Laboratory#R#of Chemical Physics, National Institute of Diabetes and Digestive#R#and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059620610"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":2.8924,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.92003129,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"137","issue":"9","first_page":"3283","last_page":"3290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12044","display_name":"Advanced Physical and Chemical Molecular Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internal-friction","display_name":"internal friction","score":0.8930000066757202},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.8899999856948853},{"id":"https://openalex.org/keywords/folding-mechanism","display_name":"folding mechanism","score":0.5550000071525574},{"id":"https://openalex.org/keywords/solvent-viscosity","display_name":"solvent viscosity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/helix-formation","display_name":"helix formation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hairpin-formation","display_name":"hairpin formation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/markov-state-models","display_name":"Markov state models","score":0.7419999837875366},{"id":"https://openalex.org/keywords/transition-path-sampling","display_name":"transition path sampling","score":0.7789999842643738},{"id":"https://openalex.org/keywords/peptides","display_name":"peptides","score":0.5249999761581421},{"id":"https://openalex.org/keywords/miniproteins","display_name":"miniproteins","score":0.9079999923706055},{"id":"https://openalex.org/keywords/energy-landscape","display_name":"energy landscape","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7691314220428467},{"id":"https://openalex.org/C2985158122","wikidata":"https://www.wikidata.org/wiki/Q82580","display_name":"Internal friction","level":2,"score":0.6960347890853882},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6133566498756409},{"id":"https://openalex.org/C46449900","wikidata":"https://www.wikidata.org/wiki/Q5303170","display_name":"Downhill folding","level":4,"score":0.5650756359100342},{"id":"https://openalex.org/C65494353","wikidata":"https://www.wikidata.org/wiki/Q180241","display_name":"Internal energy","level":2,"score":0.5649734139442444},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.5574453473091125},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5530093312263489},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.5347914099693298},{"id":"https://openalex.org/C77461463","wikidata":"https://www.wikidata.org/wiki/Q7827201","display_name":"Torsion (gastropod)","level":2,"score":0.48949944972991943},{"id":"https://openalex.org/C206276672","wikidata":"https://www.wikidata.org/wiki/Q5164839","display_name":"Contact order","level":3,"score":0.4491618573665619},{"id":"https://openalex.org/C18553476","wikidata":"https://www.wikidata.org/wiki/Q1076414","display_name":"Reaction coordinate","level":2,"score":0.43375495076179504},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.3238222599029541},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32242846488952637},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.27443817257881165},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.19555175304412842},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12757608294487},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06754225492477417},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/ja511609u","doi":"https://doi.org/10.1021/ja511609u","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja511609u","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3736423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4379956","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4379956","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4379956","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Chem Soc","raw_type":"Text"},{"id":"pmid:25721133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25721133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/ja511609u","doi":"https://doi.org/10.1021/ja511609u","is_oa":true,"landing_page_url":"https://doi.org/10.1021/ja511609u","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3413763552","display_name":"Development of a microscopic gas diffusion-reaction model for a H2 producing biocatalyst","funder_award_id":"EP/J016764/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5012189741","display_name":null,"funder_award_id":"EP/J016764/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1518891412","https://openalex.org/W1658649599","https://openalex.org/W1966078827","https://openalex.org/W1966712500","https://openalex.org/W1972675000","https://openalex.org/W1974544382","https://openalex.org/W1978734485","https://openalex.org/W1981716245","https://openalex.org/W1988529738","https://openalex.org/W1993187009","https://openalex.org/W1999033969","https://openalex.org/W2006253061","https://openalex.org/W2006926947","https://openalex.org/W2008708467","https://openalex.org/W2013536460","https://openalex.org/W2013906676","https://openalex.org/W2014095962","https://openalex.org/W2016788463","https://openalex.org/W2024423406","https://openalex.org/W2025899185","https://openalex.org/W2029137764","https://openalex.org/W2030384127","https://openalex.org/W2039592270","https://openalex.org/W2040809566","https://openalex.org/W2041367082","https://openalex.org/W2049795489","https://openalex.org/W2050509234","https://openalex.org/W2053348581","https://openalex.org/W2053960740","https://openalex.org/W2057022167","https://openalex.org/W2057477511","https://openalex.org/W2065281489","https://openalex.org/W2065864578","https://openalex.org/W2069123478","https://openalex.org/W2071075252","https://openalex.org/W2072261891","https://openalex.org/W2073086978","https://openalex.org/W2075488737","https://openalex.org/W2079077279","https://openalex.org/W2081693079","https://openalex.org/W2081926098","https://openalex.org/W2082810430","https://openalex.org/W2085213650","https://openalex.org/W2085266415","https://openalex.org/W2090850364","https://openalex.org/W2091114929","https://openalex.org/W2091983181","https://openalex.org/W2092875598","https://openalex.org/W2096347854","https://openalex.org/W2101219478","https://openalex.org/W2105646370","https://openalex.org/W2114027916","https://openalex.org/W2119516638","https://openalex.org/W2140213897","https://openalex.org/W2142578757","https://openalex.org/W2148723336","https://openalex.org/W2150614072","https://openalex.org/W2156291467","https://openalex.org/W2164011287","https://openalex.org/W2168875869","https://openalex.org/W2314276379","https://openalex.org/W2321195257","https://openalex.org/W2327000477","https://openalex.org/W2327274849","https://openalex.org/W2328628633","https://openalex.org/W2408994812","https://openalex.org/W3104316942","https://openalex.org/W4245734854"],"related_works":["https://openalex.org/W2095455634","https://openalex.org/W2049795489","https://openalex.org/W2296021502","https://openalex.org/W2314276379","https://openalex.org/W2082810430","https://openalex.org/W2401730439","https://openalex.org/W2050509234","https://openalex.org/W2018874167","https://openalex.org/W2605451286","https://openalex.org/W2024423406"],"abstract_inverted_index":{"An":[0],"outstanding":[1],"challenge":[2],"in":[3,13,68,91],"protein":[4,49,51,175,177],"folding":[5,14,22,55,93,107,135,154,158],"is":[6,33],"understanding":[7],"the":[8,19,34,58,88,92,106,153,157,168,180,184],"origin":[9,29],"of":[10,21,36,57,94,128,134,152,170,183],"\"internal":[11],"friction\"":[12],"dynamics,":[15],"experimentally":[16],"identified":[17],"from":[18,48,174],"dependence":[20],"rates":[23,76],"on":[24],"solvent":[25,66],"viscosity.":[26],"A":[27],"possible":[28],"suggested":[30],"by":[31],"simulation":[32],"crossing":[35],"local":[37],"torsion":[38,145],"barriers.":[39],"However,":[40],"it":[41],"was":[42],"unclear":[43],"why":[44],"internal":[45,89,111,141,171],"friction":[46,90,112,142,172],"varied":[47],"to":[50,73,86,176],"or":[52,125],"for":[53,167],"different":[54],"barriers":[56],"same":[59,185],"protein.":[60,186],"Using":[61],"all-atom":[62],"simulations":[63],"with":[64,70,101,109],"variable":[65],"viscosity,":[67],"conjunction":[69],"transition-path":[71],"sampling":[72],"obtain":[74],"reaction":[75],"and":[77,97,178],"analysis":[78,133],"via":[79],"Markov":[80],"state":[81],"models,":[82],"we":[83,103,138],"are":[84,113,148],"able":[85],"determine":[87],"several":[95],"peptides":[96],"miniproteins.":[98],"In":[99],"agreement":[100],"experiment,":[102],"find":[104],"that":[105,115,140],"events":[108],"greatest":[110],"those":[114],"mainly":[116],"involve":[117],"helix":[118],"formation,":[119],"while":[120],"hairpin":[121],"formation":[122],"exhibits":[123],"little":[124],"no":[126],"evidence":[127],"friction.":[129],"Via":[130],"a":[131],"careful":[132],"transition":[136],"paths,":[137],"show":[139],"arises":[143],"when":[144],"angle":[146],"changes":[147],"an":[149,165],"important":[150],"part":[151],"mechanism":[155],"near":[156],"free":[159],"energy":[160,181],"barrier.":[161],"These":[162],"results":[163],"suggest":[164],"explanation":[166],"variation":[169],"effects":[173],"across":[179],"landscape":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
