{"id":"https://openalex.org/W2015034381","doi":"https://doi.org/10.1016/1043-2760(89)90007-6","title":"Familial multiple endocrine neoplasia type 1 Mutation of a tumor suppressor gene","display_name":"Familial multiple endocrine neoplasia type 1 Mutation of a tumor suppressor gene","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W2015034381","doi":"https://doi.org/10.1016/1043-2760(89)90007-6","mag":"2015034381","pmid":"https://pubmed.ncbi.nlm.nih.gov/18411095"},"language":"en","primary_location":{"id":"doi:10.1016/1043-2760(89)90007-6","doi":"https://doi.org/10.1016/1043-2760(89)90007-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-2760(89)90007-6","pdf_url":null,"source":{"id":"https://openalex.org/S93802863","display_name":"Trends in Endocrinology and Metabolism","issn_l":"1043-2760","issn":["1043-2760","1879-3061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103038670","display_name":"Stephen J. Marx","orcid":"https://orcid.org/0000-0001-9317-332X","observed_orcids":["https://orcid.org/0000-0001-9317-332X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen J. Marx","raw_affiliation_strings":["Mineral Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mineral Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103038670"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.1937,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.25128205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"76","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14326","display_name":"Ear and Head Tumors","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8610000014305115},{"id":"https://openalex.org/keywords/chromosome-11q","display_name":"chromosome 11q","score":0.8629999756813049},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/endocrine-tumors","display_name":"endocrine tumors","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.7588001489639282},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.649742066860199},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5935386419296265},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5824525356292725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5672325491905212},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5358468294143677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5346687436103821},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5101514458656311},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.495886892080307},{"id":"https://openalex.org/C2779469564","wikidata":"https://www.wikidata.org/wiki/Q1920577","display_name":"MEN1","level":4,"score":0.483224481344223},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4703783094882965},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4195747971534729},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20510238409042358},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.1641615629196167},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08322182297706604}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/1043-2760(89)90007-6","doi":"https://doi.org/10.1016/1043-2760(89)90007-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/1043-2760(89)90007-6","pdf_url":null,"source":{"id":"https://openalex.org/S93802863","display_name":"Trends in Endocrinology and Metabolism","issn_l":"1043-2760","issn":["1043-2760","1879-3061"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:18411095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18411095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in endocrinology and metabolism: TEM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W60567553","https://openalex.org/W131086844","https://openalex.org/W131650575","https://openalex.org/W131999792","https://openalex.org/W1964619416","https://openalex.org/W1972946022","https://openalex.org/W1980847511","https://openalex.org/W1983955096","https://openalex.org/W1985528986","https://openalex.org/W2003835377","https://openalex.org/W2012034467","https://openalex.org/W2019769423","https://openalex.org/W2024873548","https://openalex.org/W2029204437","https://openalex.org/W2031829166","https://openalex.org/W2035244457","https://openalex.org/W2037473917","https://openalex.org/W2038861485","https://openalex.org/W2043087065","https://openalex.org/W2044577321","https://openalex.org/W2045553573","https://openalex.org/W2059766103","https://openalex.org/W2060577391","https://openalex.org/W2075300416","https://openalex.org/W2079816467","https://openalex.org/W2080830801","https://openalex.org/W2081200343","https://openalex.org/W2086322317","https://openalex.org/W2091723114","https://openalex.org/W2120045041","https://openalex.org/W2139998567","https://openalex.org/W2140748551","https://openalex.org/W2156872475","https://openalex.org/W2171475394","https://openalex.org/W2177441133","https://openalex.org/W2326331525","https://openalex.org/W2336883772","https://openalex.org/W2337271927","https://openalex.org/W2401443513","https://openalex.org/W2412073300","https://openalex.org/W2414424510","https://openalex.org/W2419576596","https://openalex.org/W2470744771","https://openalex.org/W2628074563","https://openalex.org/W2995432091","https://openalex.org/W4244716432","https://openalex.org/W4247040978","https://openalex.org/W4285719527","https://openalex.org/W6602461441","https://openalex.org/W6665857240","https://openalex.org/W6712909794","https://openalex.org/W6849721430"],"related_works":["https://openalex.org/W7095706598","https://openalex.org/W2133824926","https://openalex.org/W2469586271","https://openalex.org/W2162942974","https://openalex.org/W2090033080","https://openalex.org/W2411718219","https://openalex.org/W1749515022","https://openalex.org/W2043087065","https://openalex.org/W2400334567","https://openalex.org/W6902205151"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}