{"id":"https://openalex.org/W2015019014","doi":"https://doi.org/10.1179/174329210x12650506623122","title":"The phosphate makes a difference: cellular functions of NADP","display_name":"The phosphate makes a difference: cellular functions of NADP","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2015019014","doi":"https://doi.org/10.1179/174329210x12650506623122","mag":"2015019014","pmid":"https://pubmed.ncbi.nlm.nih.gov/20196923","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7067316"},"language":"en","primary_location":{"id":"doi:10.1179/174329210x12650506623122","doi":"https://doi.org/10.1179/174329210x12650506623122","is_oa":true,"landing_page_url":"https://doi.org/10.1179/174329210x12650506623122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/174329210X12650506623122?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2015019014"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1179/174329210X12650506623122?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066327574","display_name":"Line Agledal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Line Agledal","raw_affiliation_strings":["Department of Molecular Biology, University of Bergen, N-5020, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University of Bergen, N-5020, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040146378","display_name":"Marc Niere","orcid":"https://orcid.org/0000-0002-5678-302X","observed_orcids":["https://orcid.org/0000-0002-5678-302X"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Marc Niere","raw_affiliation_strings":["Department of Molecular BiologyUniversity of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular BiologyUniversity of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036605757","display_name":"Mathias Ziegler","orcid":"https://orcid.org/0000-0001-6961-2396","observed_orcids":["https://orcid.org/0000-0001-6961-2396"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Mathias Ziegler","raw_affiliation_strings":["Department of Molecular BiologyUniversity of Bergen, Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular BiologyUniversity of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4432739"],"apc_list":{"value":1625,"currency":"GBP","value_usd":1993},"apc_paid":null,"fwci":0.3004,"has_fulltext":true,"cited_by_count":217,"citation_normalized_percentile":{"value":0.2352533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"2","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5595999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadph","display_name":"NADPH","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pyridine-nucleotides","display_name":"pyridine nucleotides","score":0.9330000281333923},{"id":"https://openalex.org/keywords/electron-donors","display_name":"electron donors","score":0.4860000014305115},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6349999904632568},{"id":"https://openalex.org/keywords/redox-sensing","display_name":"redox sensing","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7870000004768372},{"id":"https://openalex.org/keywords/nad-kinase","display_name":"NAD kinase","score":0.7250000238418579},{"id":"https://openalex.org/keywords/reducing-equivalents","display_name":"reducing equivalents","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.779141366481781},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6473698616027832},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5549401640892029},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.5466927886009216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5383009314537048},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5251764059066772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5016741752624512},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4498148262500763},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.4448106288909912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44142186641693115},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.42913520336151123},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42589271068573},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4169849157333374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30704808235168457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13442957401275635},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009244","descriptor_name":"NAD+ Nucleosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019255","descriptor_name":"NADPH Oxidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1179/174329210x12650506623122","doi":"https://doi.org/10.1179/174329210x12650506623122","is_oa":true,"landing_page_url":"https://doi.org/10.1179/174329210x12650506623122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/174329210X12650506623122?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6106237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7067316","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:20196923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20196923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox report : communications in free radical research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7067316","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7067316/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1179/174329210x12650506623122","doi":"https://doi.org/10.1179/174329210x12650506623122","is_oa":true,"landing_page_url":"https://doi.org/10.1179/174329210x12650506623122","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1179/174329210X12650506623122?needAccess=true&role=button","source":{"id":"https://openalex.org/S183535129","display_name":"Redox Report","issn_l":"1351-0002","issn":["1351-0002","1743-2928"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Report","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2015019014.pdf","grobid_xml":"https://content.openalex.org/works/W2015019014.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W181908322","https://openalex.org/W1525779234","https://openalex.org/W1539831244","https://openalex.org/W1544906050","https://openalex.org/W1738677317","https://openalex.org/W1945804473","https://openalex.org/W1968004900","https://openalex.org/W1971883559","https://openalex.org/W1976685063","https://openalex.org/W1980738702","https://openalex.org/W1980828399","https://openalex.org/W1983206969","https://openalex.org/W1990667380","https://openalex.org/W1996351680","https://openalex.org/W2005531768","https://openalex.org/W2005648087","https://openalex.org/W2008209363","https://openalex.org/W2010770572","https://openalex.org/W2011766043","https://openalex.org/W2013511756","https://openalex.org/W2017159947","https://openalex.org/W2022887707","https://openalex.org/W2032545428","https://openalex.org/W2034954326","https://openalex.org/W2037104460","https://openalex.org/W2045266309","https://openalex.org/W2047044707","https://openalex.org/W2047517324","https://openalex.org/W2047687503","https://openalex.org/W2049796793","https://openalex.org/W2052229224","https://openalex.org/W2052699209","https://openalex.org/W2053448161","https://openalex.org/W2054258599","https://openalex.org/W2055783838","https://openalex.org/W2063041018","https://openalex.org/W2063562878","https://openalex.org/W2064894871","https://openalex.org/W2065420337","https://openalex.org/W2068866029","https://openalex.org/W2071021262","https://openalex.org/W2072528578","https://openalex.org/W2072929605","https://openalex.org/W2073679119","https://openalex.org/W2074190281","https://openalex.org/W2076229947","https://openalex.org/W2076930068","https://openalex.org/W2077080379","https://openalex.org/W2079935983","https://openalex.org/W2082452575","https://openalex.org/W2086266306","https://openalex.org/W2088888368","https://openalex.org/W2093057648","https://openalex.org/W2102538853","https://openalex.org/W2108609254","https://openalex.org/W2108662465","https://openalex.org/W2111810986","https://openalex.org/W2121236281","https://openalex.org/W2123503495","https://openalex.org/W2125582198","https://openalex.org/W2131960328","https://openalex.org/W2145843403","https://openalex.org/W2156197747","https://openalex.org/W2157736050","https://openalex.org/W2164431446","https://openalex.org/W2164997719","https://openalex.org/W2167424396","https://openalex.org/W2218622247","https://openalex.org/W4238581030"],"related_works":["https://openalex.org/W2014880757","https://openalex.org/W4408671931","https://openalex.org/W2149801316","https://openalex.org/W2111614709","https://openalex.org/W2157736050","https://openalex.org/W1664038668","https://openalex.org/W2168177588","https://openalex.org/W4205322090","https://openalex.org/W4285176327"],"abstract_inverted_index":{"Recent":[0],"research":[1],"has":[2,97,159],"unraveled":[3],"a":[4,35,125],"number":[5],"of":[6,9,21,25,54,70,90,119,128,135,146,153,157],"unexpected":[7],"functions":[8],"the":[10,19,51,61,94,129,144,154],"pyridine":[11],"nucleotides.":[12],"In":[13,27],"this":[14,32,167],"review,":[15],"we":[16],"will":[17],"highlight":[18],"variety":[20],"known":[22],"physiological":[23],"roles":[24,69,156],"NADP.":[26],"its":[28,88],"reduced":[29],"form":[30],"(NADPH),":[31],"molecule":[33],"represents":[34],"universal":[36],"electron":[37],"donor,":[38],"not":[39],"only":[40],"to":[41,57,81,103,142,162],"drive":[42],"biosynthetic":[43],"pathways.":[44],"Perhaps":[45],"even":[46],"more":[47],"importantly,":[48],"NADPH":[49,71,79],"is":[50,124],"unique":[52],"provider":[53],"reducing":[55],"equivalents":[56],"maintain":[58],"or":[59],"regenerate":[60],"cellular":[62,115,130],"detoxifying":[63],"and":[64,75],"antioxidative":[65],"defense":[66],"systems.":[67],"The":[68,117,133,150],"in":[72,106,166],"redox":[73],"sensing":[74],"as":[76],"substrate":[77],"for":[78],"oxidases":[80],"generate":[82],"reactive":[83],"oxygen":[84],"species":[85],"further":[86],"extend":[87],"scope":[89],"functions.":[91,100],"NADP(+),":[92],"on":[93,113],"other":[95],"hand,":[96],"acquired":[98],"signaling":[99,108],"Its":[101],"conversion":[102],"second":[104],"messengers":[105],"calcium":[107],"may":[109],"have":[110],"critical":[111,141],"impact":[112],"important":[114],"processes.":[116],"generation":[118],"NADP":[120,131,158],"by":[121],"NAD":[122],"kinases":[123],"key":[126],"determinant":[127],"concentration.":[132],"regulation":[134],"these":[136],"enzymes":[137],"may,":[138],"therefore,":[139],"be":[140],"feed":[143],"diversity":[145],"NADP-dependent":[147],"processes":[148],"adequately.":[149],"increasing":[151],"recognition":[152],"multiple":[155],"thus":[160],"led":[161],"exciting":[163],"new":[164],"insights":[165],"expanding":[168],"field.":[169]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":42},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}