{"id":"https://openalex.org/W2015012850","doi":"https://doi.org/10.1001/jama.1996.03530480025032","title":"Treatment of Chronic Depression","display_name":"Treatment of Chronic Depression","publication_year":1996,"publication_date":"1996-06-26","ids":{"openalex":"https://openalex.org/W2015012850","doi":"https://doi.org/10.1001/jama.1996.03530480025032","mag":"2015012850","pmid":"https://pubmed.ncbi.nlm.nih.gov/8648866"},"language":"en","primary_location":{"id":"doi:10.1001/jama.1996.03530480025032","doi":"https://doi.org/10.1001/jama.1996.03530480025032","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1996.03530480025032","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA: The Journal of the American Medical Association","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108631433","display_name":"Jeffrey E. Kelsey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey E. Kelsey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108631433"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"275","issue":"24","first_page":"1883","last_page":"1883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13118","display_name":"Psychological Treatments and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-depression","display_name":"chronic depression","score":0.9950000047683716},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/managed-care","display_name":"managed care","score":0.6299999952316284},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bupropion","display_name":"bupropion","score":0.996999979019165},{"id":"https://openalex.org/keywords/venlafaxine","display_name":"venlafaxine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/augmentation-therapy","display_name":"augmentation therapy","score":0.7960000038146973},{"id":"https://openalex.org/keywords/primary-care-management","display_name":"primary care management","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9840248823165894},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6747957468032837},{"id":"https://openalex.org/C2992789181","wikidata":"https://www.wikidata.org/wiki/Q427810","display_name":"Chronic depression","level":3,"score":0.4363194406032562},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3470548391342163},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.06134772300720215},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008329","descriptor_name":"Managed Care Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/jama.1996.03530480025032","doi":"https://doi.org/10.1001/jama.1996.03530480025032","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1996.03530480025032","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA: The Journal of the American Medical Association","raw_type":"journal-article"},{"id":"pmid:8648866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8648866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1984813666","https://openalex.org/W2071765053"],"related_works":["https://openalex.org/W3090794463","https://openalex.org/W1980203397","https://openalex.org/W2747340013","https://openalex.org/W2012749326","https://openalex.org/W3048605352","https://openalex.org/W2278644571","https://openalex.org/W4243933946","https://openalex.org/W2130640420","https://openalex.org/W232661417","https://openalex.org/W2000870901"],"abstract_inverted_index":{"To":[0],"the":[1,12,81],"Editor.":[2],"\u2014Dr":[4],"Goodwin":[5,138],"1":[6],"raises":[7],"numerous":[8],"important":[9],"points":[10],"concerning":[11],"intricacies":[13],"of":[14,20,101],"managing":[15],"depression":[16],"in":[17,92],"an":[18],"era":[19],"increased":[21],"managed":[22,68],"care.":[23],"However,":[24],"Goodwin's":[25],"suggestions":[26],"for":[27,86],"pharmacotherapy":[28],"were":[29],"somewhat":[30],"surprising.":[31],"Mr":[32,61],"N":[33],"apparently":[34],"showed":[35],"a":[36,70,99,115,121,129,141],"partial":[37],"response":[38,54],"to":[39,52,55,66,69,111],"imipramine,":[40,135],"but":[41,136],"did":[42],"not":[43,84,98],"do":[44],"well":[45],"on":[46],"fluoxetine;":[47],"we":[48],"are":[49],"unclear":[50],"as":[51,114,120,137],"his":[53,74],"bupropion.":[56],"It":[57],"also":[58,148],"appears":[59],"that":[60],"N's":[62],"medications":[63],"will":[64],"have":[65],"be":[67,110],"certain":[71],"extent":[72],"by":[73],"primary":[75,103],"care":[76,104],"physician.":[77],"Given":[79],"this,":[80],"rationale":[82],"is":[83,96,128],"clear":[85],"retrying":[87],"bupropion":[88],"and":[89],"then":[90],"engaging":[91],"augmentation":[93],"therapy,":[94],"which":[95],"usually":[97],"part":[100],"routine":[102],"practice.":[105],"A":[106],"different":[107],"approach":[108,147],"would":[109,149],"try":[112],"venlafaxine":[113],"first":[116],"choice,":[117],"rather":[118],"than":[119],"second-":[122],"or":[123],"third-line":[124],"agent,":[125],"since":[126],"it":[127],"mixed":[130],"reuptake":[131],"inhibitor":[132],"2":[133],"like":[134],"mentioned,":[139],"has":[140],"favorable":[142],"adverse":[143],"effect":[144],"profile.":[145],"This":[146],"simplify":[150],"treatment":[151]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
