{"id":"https://openalex.org/W2014994529","doi":"https://doi.org/10.1107/s0907444913015424","title":"Structure of the red fluorescent protein from a lancelet (Branchiostoma lanceolatum): a novel GYG chromophore covalently bound to a nearby tyrosine","display_name":"Structure of the red fluorescent protein from a lancelet (Branchiostoma lanceolatum): a novel GYG chromophore covalently bound to a nearby tyrosine","publication_year":2013,"publication_date":"2013-08-16","ids":{"openalex":"https://openalex.org/W2014994529","doi":"https://doi.org/10.1107/s0907444913015424","mag":"2014994529","pmid":"https://pubmed.ncbi.nlm.nih.gov/23999308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760133"},"language":"en","primary_location":{"id":"doi:10.1107/s0907444913015424","doi":"https://doi.org/10.1107/s0907444913015424","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s0907444913015424","pdf_url":"http://journals.iucr.org/d/issues/2013/09/00/lv5043/lv5043.pdf","source":{"id":"https://openalex.org/S114502960","display_name":"Acta Crystallographica Section D Biological Crystallography","issn_l":"0907-4449","issn":["0907-4449","1399-0047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section D Biological Crystallography","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://journals.iucr.org/d/issues/2013/09/00/lv5043/lv5043.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016035860","display_name":"Vladimir Z. Pletnev","orcid":"https://orcid.org/0000-0003-1453-6597","observed_orcids":["https://orcid.org/0000-0003-1453-6597"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Z. Pletnev","raw_affiliation_strings":["Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031117472","display_name":"Nadya V. Pletneva","orcid":"https://orcid.org/0000-0001-9681-4022","observed_orcids":["https://orcid.org/0000-0001-9681-4022"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nadya V. Pletneva","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007827215","display_name":"Konstantin A. Lukyanov","orcid":"https://orcid.org/0000-0001-9845-2088","observed_orcids":["https://orcid.org/0000-0001-9845-2088"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin A. Lukyanov","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056346975","display_name":"Ekaterina A. Souslova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina A. Souslova","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409112","display_name":"Arkady F. Fradkov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Arkady F. Fradkov","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060028352","display_name":"Dmitriy M. Chudakov","orcid":"https://orcid.org/0000-0003-0430-790X","observed_orcids":["https://orcid.org/0000-0003-0430-790X","https://orcid.org/0000-0003-2143-9824","https://orcid.org/0000-0001-6273-4008"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry M. Chudakov","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111657490","display_name":"Tatyana V Chepurnykh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatyana Chepurnykh","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065915188","display_name":"Ilia V. Yampolsky","orcid":"https://orcid.org/0000-0003-2558-2476","observed_orcids":["https://orcid.org/0000-0003-2558-2476"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210105571","display_name":"Institute of Bioorganic Chemistry","ror":"https://ror.org/01dg04253","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210105571","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ilia V. Yampolsky","raw_affiliation_strings":["Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shemyakin\u2013Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210105571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027980832","display_name":"Alexander Wlodawer","orcid":"https://orcid.org/0000-0002-5510-9703","observed_orcids":["https://orcid.org/0000-0002-5510-9703"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Wlodawer","raw_affiliation_strings":["Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015434460","display_name":"Zbigniew Dauter","orcid":"https://orcid.org/0000-0002-8806-9066","observed_orcids":["https://orcid.org/0000-0002-8806-9066"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Dauter","raw_affiliation_strings":["Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, IL 60439, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, IL 60439, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102831144","display_name":"Sergei V. Pletnev","orcid":"https://orcid.org/0000-0002-2502-4637","observed_orcids":["https://orcid.org/0000-0002-2502-4637"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sergei Pletnev","raw_affiliation_strings":["Basic Research Program, SAIC-Frederick, Argonne, IL 60439, USA","Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, IL 60439, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Research Program, SAIC-Frederick, Argonne, IL 60439, USA","institution_ids":["https://openalex.org/I880747138"]},{"raw_affiliation_string":"Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne, IL 60439, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102831144"],"corresponding_institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I880747138"],"apc_list":{"value":4740,"currency":"USD","value_usd":4740},"apc_paid":null,"fwci":1.0095,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.75145576,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"9","first_page":"1850","last_page":"1860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-fluorescent-protein","display_name":"red fluorescent protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/branchiostoma-lanceolatum","display_name":"Branchiostoma lanceolatum","score":0.9660000205039978},{"id":"https://openalex.org/keywords/amphioxus","display_name":"amphioxus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stokes-shift","display_name":"Stokes shift","score":0.7490000128746033},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.4569999873638153},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.777616024017334},{"id":"https://openalex.org/C3019336641","wikidata":"https://www.wikidata.org/wiki/Q55643886","display_name":"Fluorescent protein","level":4,"score":0.7035122513771057},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.5366866588592529},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5300963521003723},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4880913496017456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32147374749183655},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.26500391960144043},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15409201383590698},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13895589113235474},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.12557339668273926},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.07635059952735901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097573","descriptor_name":"Red Fluorescent Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064175","descriptor_name":"Lancelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1107/s0907444913015424","doi":"https://doi.org/10.1107/s0907444913015424","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s0907444913015424","pdf_url":"http://journals.iucr.org/d/issues/2013/09/00/lv5043/lv5043.pdf","source":{"id":"https://openalex.org/S114502960","display_name":"Acta Crystallographica Section D Biological Crystallography","issn_l":"0907-4449","issn":["0907-4449","1399-0047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section D Biological Crystallography","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3116481","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760133","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3760133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3760133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallogr D Biol Crystallogr","raw_type":"Text"},{"id":"pmid:23999308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23999308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta crystallographica. Section D, Biological crystallography","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1107/s0907444913015424","doi":"https://doi.org/10.1107/s0907444913015424","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s0907444913015424","pdf_url":"http://journals.iucr.org/d/issues/2013/09/00/lv5043/lv5043.pdf","source":{"id":"https://openalex.org/S114502960","display_name":"Acta Crystallographica Section D Biological Crystallography","issn_l":"0907-4449","issn":["0907-4449","1399-0047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section D Biological Crystallography","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1521411027","display_name":null,"funder_award_id":"No. HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1678787968","display_name":null,"funder_award_id":"Contract No. W-31-109-Eng-38","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1756342139","display_name":null,"funder_award_id":"W-31-109-Eng38","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G18202666","display_name":null,"funder_award_id":"W-31-109-ENG-38","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G2123841078","display_name":null,"funder_award_id":"W - 31 - 109 - Eng - 38","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4585269469","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G572720644","display_name":null,"funder_award_id":"W-31-109-ENG-38","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320321912","display_name":"Ministry of Education and Science of the Russian Federation","ror":"https://ror.org/00ghqgy32"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014994529.pdf","grobid_xml":"https://content.openalex.org/works/W2014994529.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1539796472","https://openalex.org/W1544900705","https://openalex.org/W1965804266","https://openalex.org/W1973888391","https://openalex.org/W1978892474","https://openalex.org/W1980797877","https://openalex.org/W1996669224","https://openalex.org/W2000435338","https://openalex.org/W2006310856","https://openalex.org/W2014293907","https://openalex.org/W2022889543","https://openalex.org/W2036075498","https://openalex.org/W2039603790","https://openalex.org/W2050717506","https://openalex.org/W2054762608","https://openalex.org/W2057397408","https://openalex.org/W2059536603","https://openalex.org/W2060913542","https://openalex.org/W2078339242","https://openalex.org/W2081912151","https://openalex.org/W2082035619","https://openalex.org/W2089343984","https://openalex.org/W2091012365","https://openalex.org/W2096287802","https://openalex.org/W2104048912","https://openalex.org/W2104109138","https://openalex.org/W2105332737","https://openalex.org/W2105448371","https://openalex.org/W2108921801","https://openalex.org/W2113671566","https://openalex.org/W2119825110","https://openalex.org/W2122449403","https://openalex.org/W2123440527","https://openalex.org/W2129995310","https://openalex.org/W2131794448","https://openalex.org/W2131871062","https://openalex.org/W2134540936","https://openalex.org/W2134778615","https://openalex.org/W2135740919","https://openalex.org/W2138468193","https://openalex.org/W2138778752","https://openalex.org/W2139414608","https://openalex.org/W2144081223","https://openalex.org/W2146080841","https://openalex.org/W2146236564","https://openalex.org/W2153924661","https://openalex.org/W2159211495","https://openalex.org/W2161422945","https://openalex.org/W2164564852","https://openalex.org/W2491458126","https://openalex.org/W4206699045"],"related_works":["https://openalex.org/W4236442045","https://openalex.org/W2145721153","https://openalex.org/W2006310856","https://openalex.org/W2058254034","https://openalex.org/W2131794448","https://openalex.org/W4200571760","https://openalex.org/W1984953025","https://openalex.org/W7098028127","https://openalex.org/W7045977081","https://openalex.org/W1512531853"],"abstract_inverted_index":{"A":[0],"key":[1],"property":[2],"of":[3,5,23,61,74,105,111,144,174,179,200,203,210,224,230,245],"proteins":[4,57,91,159],"the":[6,32,43,48,62,66,71,94,103,172,177,180,198,208,217,222,225,235,239],"green":[7,44,75],"fluorescent":[8,90,158],"protein":[9,63],"(GFP)":[10],"family":[11],"is":[12],"their":[13],"ability":[14],"to":[15,59,163,190],"form":[16],"a":[17,106],"chromophore":[18,46,194],"group":[19],"by":[20,249],"post-translational":[21],"modifications":[22,60,201],"internal":[24],"amino":[25],"acids,":[26],"e.g.":[27],"Ser65-Tyr66-Gly67":[28],"in":[29,55,156,185],"GFP":[30],"from":[31,93,160],"jellyfish":[33],"Aequorea":[34,186],"victoria":[35],"(Cnidaria).":[36],"Numerous":[37],"structural":[38],"studies":[39],"have":[40,131,152],"demonstrated":[41],"that":[42,151],"GFP-like":[45],"represents":[47],"`core'":[49],"structure,":[50],"which":[51,88,130,188],"can":[52],"be":[53,191],"extended":[54],"red-shifted":[56],"owing":[58],"backbone":[64],"at":[65,176],"first":[67],"chromophore-forming":[68,168],"position.":[69],"Here,":[70],"three-dimensional":[72],"structures":[73],"laGFP":[76],"(\u03bbex/\u03bbem":[77,84],"=":[78],"502/511":[79],"nm)":[80,244],"and":[81,121,135,196,207,221,238],"red":[82,107,205,236],"laRFP":[83,146,246],"\u2243":[85],"521/592":[86],"nm),":[87],"are":[89,118],"(FPs)":[92],"lancelet":[95],"Branchiostoma":[96],"lanceolatum":[97],"(Chordata),":[98],"were":[99],"determined":[100],"together":[101],"with":[102,113,127],"structure":[104,143],"variant":[108],"laRFP-\u0394S83":[109],"(deletion":[110],"Ser83)":[112],"improved":[114],"folding.":[115],"Lancelet":[116],"FPs":[117],"evolutionarily":[119],"distant":[120],"share":[122],"only":[123],"\u223c20%":[124],"sequence":[125,169],"identity":[126],"cnidarian":[128],"FPs,":[129],"been":[132,154],"extensively":[133],"characterized":[134],"widely":[136],"used":[137],"as":[138],"genetically":[139],"encoded":[140],"probes.":[141],"The":[142,228],"red-emitting":[145],"revealed":[147],"three":[148],"exceptional":[149],"features":[150],"not":[153],"observed":[155],"wild-type":[157],"Cnidaria":[161],"reported":[162],"date:":[164],"(i)":[165],"an":[166,211],"unusual":[167,213],"Gly58-Tyr59-Gly60,":[170],"(ii)":[171],"presence":[173,209],"Gln211":[175],"position":[178],"conserved":[181],"catalytic":[182],"Glu":[183],"(Glu222":[184],"GFP),":[187],"proved":[189],"crucial":[192],"for":[193],"formation,":[195],"(iii)":[197],"absence":[199],"typical":[202],"known":[204],"chromophores":[206],"extremely":[212],"covalent":[214,232],"bond":[215,233],"between":[216],"Tyr59":[218],"C(\u03b2)":[219],"atom":[220],"hydroxyl":[223],"proximal":[226],"Tyr62.":[227],"impact":[229],"this":[231],"on":[234],"emission":[237],"large":[240],"Stokes":[241],"shift":[242],"(\u223c70":[243],"was":[247],"verified":[248],"extensive":[250],"structure-based":[251],"site-directed":[252],"mutagenesis.":[253]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}