{"id":"https://openalex.org/W2014988063","doi":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","title":"Prolonged, alternating chemotherapy for extensive small cell lung cancer. A southwest oncology group study","display_name":"Prolonged, alternating chemotherapy for extensive small cell lung cancer. A southwest oncology group study","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2014988063","doi":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","mag":"2014988063","pmid":"https://pubmed.ncbi.nlm.nih.gov/8387881"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","doi":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930601%2971%3A11%3C3509%3A%3AAID-CNCR2820711108%3E3.0.CO%3B2-%23","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930601%2971%3A11%3C3509%3A%3AAID-CNCR2820711108%3E3.0.CO%3B2-%23","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108527466","display_name":"Robert B. Livingston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert B. Livingston","raw_affiliation_strings":["Puget Sound Oncology Consortium, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puget Sound Oncology Consortium, Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109120503","display_name":"Tove Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tove Thompson","raw_affiliation_strings":["Puget Sound Oncology Consortium, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puget Sound Oncology Consortium, Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103408877","display_name":"John J. Crowley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John J. Crowley","raw_affiliation_strings":["Southwest Oncology Group Statistical Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest Oncology Group Statistical Center, Seattle, Washington","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027304240","display_name":"Stephen K. Williamson","orcid":"https://orcid.org/0000-0003-4118-1242","observed_orcids":["https://orcid.org/0000-0003-4118-1242"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen K. Williamson","raw_affiliation_strings":["University of Kansas Medical Center, Kansas City, Kansas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas Medical Center, Kansas City, Kansas","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082791022","display_name":"Frederick J. Meyers","orcid":"https://orcid.org/0000-0002-4456-4647","observed_orcids":["https://orcid.org/0000-0002-4456-4647"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick J. Meyers","raw_affiliation_strings":["University of California\u2010Davis, Sacramento, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2010Davis, Sacramento, California","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110222461","display_name":"Timothy J. O\u2019Rourke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289568071","display_name":"Brooke Army Medical Center","ror":"https://ror.org/00m1mwc36","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289568071","https://openalex.org/I1330347796","https://openalex.org/I2800250139","https://openalex.org/I2800386880"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy O'Rourke","raw_affiliation_strings":["Brooke Army Medical Center, Fort Sam Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brooke Army Medical Center, Fort Sam Houston, Texas","institution_ids":["https://openalex.org/I1289568071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113546972","display_name":"John R. Neefe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. Neefe","raw_affiliation_strings":["University of Kentucky Medical Center, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky Medical Center, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108527466"],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.1557,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5238018,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"11","first_page":"3509","last_page":"3513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/extensive-stage-disease","display_name":"extensive disease","score":0.6029999852180481},{"id":"https://openalex.org/keywords/alternating-chemotherapy","display_name":"alternating chemotherapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/etoposide-and-cisplatin","display_name":"cisplatin/etoposide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cav-regimen","display_name":"CAV regimen","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9340000152587891},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dose-intensity","display_name":"dose intensity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.6650000214576721},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.824999988079071},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9235244989395142},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.8548621535301208},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.7949916124343872},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7245498895645142},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.7179749011993408},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5378707051277161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5374084115028381},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39662879705429077},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3800538182258606},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35077422857284546}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","doi":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930601%2971%3A11%3C3509%3A%3AAID-CNCR2820711108%3E3.0.CO%3B2-%23","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8387881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","doi":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19930601)71:11<3509::aid-cncr2820711108>3.0.co;2-#","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819930601%2971%3A11%3C3509%3A%3AAID-CNCR2820711108%3E3.0.CO%3B2-%23","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1632577609","display_name":null,"funder_award_id":"CA 37429","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1958973285","display_name":null,"funder_award_id":"CA 20319","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G413878341","display_name":null,"funder_award_id":"CA-12644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4281693517","display_name":"Southwest Oncology Group","funder_award_id":"U10CA020319","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6793431733","display_name":"SOUTHWEST ONCOLOGY GROUP STUDIES","funder_award_id":"U10CA012644","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7747134535","display_name":"SWOG Community Clinical Oncology Program Research Base","funder_award_id":"U10CA037429","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014988063.pdf","grobid_xml":"https://content.openalex.org/works/W2014988063.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1868305875","https://openalex.org/W1884032213","https://openalex.org/W1955033393","https://openalex.org/W1999744563","https://openalex.org/W2097597328","https://openalex.org/W2105257387","https://openalex.org/W2122995772","https://openalex.org/W2180031316","https://openalex.org/W2236604469","https://openalex.org/W2276477497"],"related_works":["https://openalex.org/W2010794129","https://openalex.org/W2037357429","https://openalex.org/W2395847672","https://openalex.org/W1993373426","https://openalex.org/W2184249123","https://openalex.org/W1996360448","https://openalex.org/W2236604469","https://openalex.org/W2123767004","https://openalex.org/W1975100056","https://openalex.org/W2412795043"],"abstract_inverted_index":{"BACKGROUND:":[0],"Etoposide":[1],"may":[2],"be":[3,275],"schedule":[4],"dependent":[5],"in":[6,22,56,132,217,227,266,271,292],"small":[7],"cell":[8],"lung":[9],"cancer":[10],"(SCLC),":[11],"and":[12,45,48,71,75,101,127,150,221,268],"some":[13],"data":[14],"suggest":[15,279],"a":[16,153,244,252],"benefit":[17],"for":[18,79,91,98,256,302],"increased":[19],"dose":[20,30,234],"intensity":[21,31,235],"this":[23],"disease.":[24],"This":[25],"study":[26],"attempted":[27],"to":[28,137,274],"optimize":[29],"using":[32,288],"an":[33,119],"outpatient":[34],"program":[35],"that":[36,247],"included":[37],"prolonged,":[38],"oral":[39,264,269],"etoposide":[40,76,265],"administration.":[41],"METHODS:":[42],"Cisplatin-etoposide":[43],"(PE)":[44],"cyclophosphamide,":[46],"doxorubicin,":[47],"vincristine":[49,102],"(CAV)":[50],"were":[51],"alternated":[52],"at":[53,182],"monthly":[54],"intervals":[55],"patients":[57,117,165,219],"with":[58,125,203,299],"extensive":[59,303],"SCLC.":[60],"PE":[61,123,267],"was":[62,85,135,192,200,249],"given":[63],"as":[64,87,243],"cisplatin":[65],"50":[66,77],"mg/m2":[67],"on":[68,106,172],"days":[69,81,93],"1":[70,108],"8":[72],"intravenously":[73],"(i.v.)":[74],"mg/m2/day":[78,90],"14":[80],"by":[82,156],"mouth.":[83],"CAV":[84,272],"administered":[86],"cyclophosphamide":[88,270],"60":[89],"21":[92],"orally,":[94],"doxorubicin":[95],"20":[96,164],"mg/m2/week":[97],"three":[99,204,228],"doses,":[100],"2":[103],"mg":[104],"i.v.":[105],"day":[107],"only.":[109],"At":[110],"the":[111,195,232,294],"end":[112],"of":[113,122,231,246,254,262],"4":[114,147,185,212,223],"months,":[115],"responding":[116],"received":[118],"additional":[120,163],"course":[121],"alternating":[124,290,300],"CAV,":[126],"whole-brain":[128],"irradiation":[129],"(3000":[130],"cGy":[131],"15":[133],"fractions)":[134],"delivered":[136,233],"clinical":[138],"complete":[139],"responders":[140],"(CR).":[141],"RESULTS:":[142],"Among":[143],"61":[144],"eligible":[145],"patients,":[146],"achieved":[148],"CR,":[149],"11":[151],"had":[152],"partial":[154],"remission,":[155],"strict":[157],"Southwest":[158],"Oncology":[159],"Group":[160],"criteria.":[161],"An":[162],"demonstrated":[166],"greater":[167],"than":[168],"50%":[169],"tumor":[170],"shrinkage":[171],"one":[173],"disease":[174],"assessment":[175],"but":[176],"did":[177],"not":[178],"have":[179],"confirming":[180],"measurements":[181],"all":[183,257],"sites":[184],"weeks":[186],"later.":[187],"The":[188,198],"overall":[189],"response":[190],"rate":[191],"57%,":[193],"including":[194],"latter":[196],"group.":[197],"toxicity":[199],"primarily":[201],"hematologic,":[202],"treatment-related":[205],"deaths":[206],"from":[207,284],"neutropenic":[208],"infection":[209],"(5%).":[210,229],"Grade":[211,222],"neutropenia":[213],"(<":[214,225],"500/microliters)":[215],"occurred":[216],"nine":[218],"(15%)":[220],"thrombocytopenia":[224],"25,000/microliters),":[226],"Analysis":[230],"(in":[236],"milligrams":[237],"per":[238,241],"square":[239],"meter":[240],"week)":[242],"function":[245],"which":[248,293],"planned":[250],"revealed":[251],"mean":[253],"93%":[255],"courses.":[258],"CONCLUSIONS:":[259],"Although":[260],"substitution":[261],"prolonged":[263],"proved":[273],"feasible,":[276],"these":[277,289],"results":[278],"no":[280],"advantage":[281],"over":[282],"those":[283],"other":[285],"reported":[286],"series":[287],"regimens":[291],"agents":[295],"are":[296],"pulsed.":[297],"Experience":[298],"PE-CAV":[301],"SCLC":[304],"is":[305],"reviewed.":[306]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}