{"id":"https://openalex.org/W2014960265","doi":"https://doi.org/10.1159/000346128","title":"Cariporide, a Specific Na+/H+ Exchanger 1 Blocker, Inhibits Neointimal Proliferation Induced by Advanced Glycation End Products in a Balloon Injury Rat Model","display_name":"Cariporide, a Specific Na+/H+ Exchanger 1 Blocker, Inhibits Neointimal Proliferation Induced by Advanced Glycation End Products in a Balloon Injury Rat Model","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2014960265","doi":"https://doi.org/10.1159/000346128","mag":"2014960265","pmid":"https://pubmed.ncbi.nlm.nih.gov/23344254"},"language":"en","primary_location":{"id":"doi:10.1159/000346128","doi":"https://doi.org/10.1159/000346128","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000346128","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004736341","display_name":"Shujin Wu","orcid":"https://orcid.org/0000-0001-6260-6401","observed_orcids":["https://orcid.org/0000-0001-6260-6401"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujin Wu","raw_affiliation_strings":["Department of Pharmacy, Gan Su Province Hospital, Lan Zhou, China","Pharmacy and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Gan Su Province Hospital, Lan Zhou, China","institution_ids":["https://openalex.org/I4210114785"]},{"raw_affiliation_string":"Pharmacy and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083030378","display_name":"Qingshan Yang","orcid":"https://orcid.org/0000-0001-8791-8380","observed_orcids":["https://orcid.org/0000-0001-8791-8380"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingshan Yang","raw_affiliation_strings":["Department of Pharmacology, Pharmaceutical College, Central South University, Changsha, Hunan, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Pharmaceutical College, Central South University, Changsha, Hunan, China,","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363018","display_name":"Qianqian Liu","orcid":"https://orcid.org/0009-0009-1171-6251","observed_orcids":["https://orcid.org/0009-0009-1171-6251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qianqian Liu","raw_affiliation_strings":["Department of Emergency, Cang Zhou Integrated Traditional and Western Medicine Hospital, Cang Zhou"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Cang Zhou Integrated Traditional and Western Medicine Hospital, Cang Zhou","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529697","display_name":"Tao Song","orcid":"https://orcid.org/0000-0003-3988-3536","observed_orcids":["https://orcid.org/0000-0003-3988-3536"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Song","raw_affiliation_strings":["Orthopaedics, Gan Su Province Hospital, Lan Zhou, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Gan Su Province Hospital, Lan Zhou, and","institution_ids":["https://openalex.org/I4210114785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100522154","display_name":"Shouhong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouhong Zhou","raw_affiliation_strings":["Orthopaedics, Gan Su Province Hospital, Lan Zhou, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Gan Su Province Hospital, Lan Zhou, and","institution_ids":["https://openalex.org/I4210114785"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuhui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhui Liu","raw_affiliation_strings":["Orthopaedics, Gan Su Province Hospital, Lan Zhou, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Gan Su Province Hospital, Lan Zhou, and","institution_ids":["https://openalex.org/I4210114785"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077781656","display_name":"Liying Liu","orcid":"https://orcid.org/0000-0003-2480-3732","observed_orcids":["https://orcid.org/0000-0003-2480-3732"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liying Liu","raw_affiliation_strings":["Orthopaedics, Gan Su Province Hospital, Lan Zhou, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Gan Su Province Hospital, Lan Zhou, and","institution_ids":["https://openalex.org/I4210114785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4179,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.56076592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"91","issue":"3-4","first_page":"123","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cariporide","display_name":"cariporide","score":1.0},{"id":"https://openalex.org/keywords/na-h-exchanger-1","display_name":"NHX1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/balloon-injury","display_name":"balloon injury","score":0.8180000185966492},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.996999979019165},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8209999799728394},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6470000147819519},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6042383909225464},{"id":"https://openalex.org/C2778095995","wikidata":"https://www.wikidata.org/wiki/Q17147174","display_name":"Neointimal hyperplasia","level":4,"score":0.522128164768219},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4996225833892822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46408411860466003},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43158769607543945},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36447179317474365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19804736971855164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1852875053882599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18220388889312744},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.13369828462600708},{"id":"https://openalex.org/C2778583881","wikidata":"https://www.wikidata.org/wiki/Q1325542","display_name":"Stent","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000800","descriptor_name":"Angioplasty, Balloon","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017127","descriptor_name":"Glycation End Products, Advanced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020212","descriptor_name":"Carotid Artery Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D020212","descriptor_name":"Carotid Artery Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020212","descriptor_name":"Carotid Artery Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058426","descriptor_name":"Neointima","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D058426","descriptor_name":"Neointima","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058426","descriptor_name":"Neointima","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000346128","doi":"https://doi.org/10.1159/000346128","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000346128","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:23344254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23344254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327480","display_name":"China Institute of Atomic Energy","ror":"https://ror.org/00v5gqm66"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1994590258","https://openalex.org/W1999265356","https://openalex.org/W2031026609","https://openalex.org/W2034340607","https://openalex.org/W2048053921","https://openalex.org/W2061067846","https://openalex.org/W2064766217","https://openalex.org/W2065187047","https://openalex.org/W2066565780","https://openalex.org/W2074931383","https://openalex.org/W2093881303","https://openalex.org/W2095820351","https://openalex.org/W2098687216","https://openalex.org/W2123526886","https://openalex.org/W2124641134","https://openalex.org/W2129408819","https://openalex.org/W2144319892","https://openalex.org/W2150367143","https://openalex.org/W2151890309","https://openalex.org/W2153100816","https://openalex.org/W2158814411","https://openalex.org/W2312347828","https://openalex.org/W2365383382","https://openalex.org/W2381622085"],"related_works":["https://openalex.org/W2366698738","https://openalex.org/W1999265356","https://openalex.org/W7096280262","https://openalex.org/W2381622085","https://openalex.org/W2166511358","https://openalex.org/W2105559528","https://openalex.org/W6998394360","https://openalex.org/W2031026609","https://openalex.org/W1996120056","https://openalex.org/W2387740299"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,68,81,142],"association":[2],"between":[3],"diabetes":[4],"and":[5,53,65,109,120,125,138,156,166],"neointimal":[6,38,99,149],"expansion":[7],"after":[8],"vascular":[9,101],"injury":[10,46],"has":[11],"been":[12],"attributed":[13],"to":[14],"the":[15,26,84,122,153,157],"accumulation":[16],"of":[17,29,50,70,83,159],"advanced":[18],"glycation":[19],"end":[20],"products":[21],"(AGEs).":[22],"Here":[23],"we":[24],"investigated":[25],"inhibitory":[27],"effect":[28],"cariporide,":[30],"a":[31,44],"specific":[32,78],"Na(+)/H(+)":[33],"exchanger":[34],"1":[35],"blocker,":[36],"on":[37],"proliferation":[39,155],"induced":[40],"by":[41,59,77,91,151],"AGEs":[42],"in":[43],"balloon":[45],"model.":[47],"METHODS:":[48],"Expression":[49],"cyclooxygenase-2":[51],"(COX-2)":[52],"matrix":[54],"metalloproteinase":[55],"(MMP)":[56],"was":[57,75,89],"monitored":[58],"reverse":[60],"transcription-polymerase":[61],"chain":[62],"reaction":[63],"(RT-PCR)":[64],"real-time":[66],"PCR.":[67],"level":[69,119],"reactive":[71],"oxygen":[72],"species":[73],"(ROS)":[74],"determined":[76],"fluorescent":[79],"probe.":[80],"phosphorylation":[82],"nuclear":[85],"factor-\u0138B":[86],"(NF-\u0138B)":[87],"system":[88],"studied":[90],"Western":[92],"blot.":[93],"RESULTS:":[94],"Cariporide":[95],"significantly":[96],"suppressed":[97],"AGE-induced":[98,116,135,148],"hyperplasia,":[100],"smooth":[102],"muscle":[103],"cell":[104],"(VSMC)":[105],"proliferation,":[106],"COX-2,":[107,160],"MMP-2":[108],"MMP-9":[110,162],"expression.":[111],"In":[112],"addition,":[113],"cariporide":[114,133,146],"decreased":[115],"ROS,":[117],"malondiadehyde":[118],"increased":[121],"superoxide":[123],"dismutase":[124],"glutathione":[126],"peroxidase":[127],"activity.":[128],"We":[129],"also":[130],"found":[131],"that":[132,145],"blocked":[134],"NF-\u0138B":[136,167],"activation":[137],"inhibitor-\u0138B":[139],"degradation.":[140],"CONCLUSIONS:":[141],"results":[143],"indicated":[144],"inhibited":[147],"formation":[150],"suppressing":[152],"VSMC":[154],"up-regulation":[158],"MMP-2,":[161],"via":[163],"inhibiting":[164],"ROS":[165],"activation.":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}