{"id":"https://openalex.org/W2014906700","doi":"https://doi.org/10.1097/coc.0b013e31817ff8e4","title":"Radiotherapy in the Treatment of Resectable Rectal Adenocarcinoma","display_name":"Radiotherapy in the Treatment of Resectable Rectal Adenocarcinoma","publication_year":2009,"publication_date":"2009-11-27","ids":{"openalex":"https://openalex.org/W2014906700","doi":"https://doi.org/10.1097/coc.0b013e31817ff8e4","mag":"2014906700","pmid":"https://pubmed.ncbi.nlm.nih.gov/19593081"},"language":"en","primary_location":{"id":"doi:10.1097/coc.0b013e31817ff8e4","doi":"https://doi.org/10.1097/coc.0b013e31817ff8e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/coc.0b013e31817ff8e4","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008642709","display_name":"William M. Mendenhall","orcid":"https://orcid.org/0000-0002-6592-2810","observed_orcids":["https://orcid.org/0000-0002-6592-2810"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William M. Mendenhall","raw_affiliation_strings":["Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA. mendwm@shands.ufl.edu","Department of Radiation Oncology, University of Florida College of Medicine, Gainesville,#R#Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA. mendwm@shands.ufl.edu","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Florida College of Medicine, Gainesville,#R#Florida, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074319725","display_name":"Robert A. Zlotecki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert A. Zlotecki","raw_affiliation_strings":["Department of Radiation Oncology and \u2020Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and \u2020Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000236643","display_name":"Felicia E. Snead","orcid":"https://orcid.org/0000-0002-4732-3224","observed_orcids":["https://orcid.org/0000-0002-4732-3224"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felicia E. Snead","raw_affiliation_strings":["Department of Radiation Oncology and \u2020Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology and \u2020Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180","observed_orcids":["https://orcid.org/0000-0002-6249-9180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas J. George","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013408333","display_name":"Robert Marsh","orcid":"https://orcid.org/0000-0003-1871-096X","observed_orcids":["https://orcid.org/0000-0003-1871-096X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert D. Marsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011754787","display_name":"Charles M. Mendenhall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801543802","display_name":"Phoebe Putney Memorial Hospital","ror":"https://ror.org/02y2qcy45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801543802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles M. Mendenhall","raw_affiliation_strings":["Department of Radiation Oncology, Phoebe Putney Memorial Hospital, Albany, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Phoebe Putney Memorial Hospital, Albany, Georgia","institution_ids":["https://openalex.org/I2801543802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109891588","display_name":"W. Robert Rout","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Robert Rout","raw_affiliation_strings":["Department of Surgery, University of Florida College of Medicine, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Florida College of Medicine, Gainesville, Florida","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000236643","https://openalex.org/A5008642709","https://openalex.org/A5074319725"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":0.0879,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.12809625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"6","first_page":"629","last_page":"638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-adenocarcinoma","display_name":"rectal adenocarcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/sphincter-preservation","display_name":"sphincter preservation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/transanal-excision","display_name":"transanal excision","score":0.8510000109672546},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/postoperative-chemoradiotherapy","display_name":"postoperative chemoradiotherapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/local-regional-recurrence","display_name":"local-regional recurrence","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-downstaging","display_name":"tumor downstaging","score":0.8650000095367432},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9779741764068604},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6889966726303101},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6791119575500488},{"id":"https://openalex.org/C2780877482","wikidata":"https://www.wikidata.org/wiki/Q746416","display_name":"Sphincter","level":2,"score":0.6139361262321472},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.573149561882019},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5207026600837708},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4350408613681793},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18683168292045593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13226556777954102}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/coc.0b013e31817ff8e4","doi":"https://doi.org/10.1097/coc.0b013e31817ff8e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/coc.0b013e31817ff8e4","pdf_url":null,"source":{"id":"https://openalex.org/S130927242","display_name":"American Journal of Clinical Oncology","issn_l":"0277-3732","issn":["0277-3732","1537-453X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:19593081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19593081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W182194735","https://openalex.org/W330489597","https://openalex.org/W1585172067","https://openalex.org/W1709006658","https://openalex.org/W1769613332","https://openalex.org/W1820812244","https://openalex.org/W1897515640","https://openalex.org/W1963592300","https://openalex.org/W1963782590","https://openalex.org/W1967022481","https://openalex.org/W1967938594","https://openalex.org/W1969801540","https://openalex.org/W1969867128","https://openalex.org/W1970899657","https://openalex.org/W1971964929","https://openalex.org/W1975438658","https://openalex.org/W1975740251","https://openalex.org/W1977351090","https://openalex.org/W1978224105","https://openalex.org/W1978751590","https://openalex.org/W1979642189","https://openalex.org/W1985262661","https://openalex.org/W1988212311","https://openalex.org/W1989634099","https://openalex.org/W1993390006","https://openalex.org/W1997493896","https://openalex.org/W1999757095","https://openalex.org/W2004780049","https://openalex.org/W2008963816","https://openalex.org/W2009912942","https://openalex.org/W2010762522","https://openalex.org/W2014797465","https://openalex.org/W2020956130","https://openalex.org/W2021416608","https://openalex.org/W2028415243","https://openalex.org/W2030158623","https://openalex.org/W2031237139","https://openalex.org/W2032429145","https://openalex.org/W2035393803","https://openalex.org/W2036244434","https://openalex.org/W2039557289","https://openalex.org/W2040095095","https://openalex.org/W2042571016","https://openalex.org/W2045881147","https://openalex.org/W2048254702","https://openalex.org/W2049485751","https://openalex.org/W2049921456","https://openalex.org/W2050020104","https://openalex.org/W2052569414","https://openalex.org/W2053309159","https://openalex.org/W2055141688","https://openalex.org/W2060163598","https://openalex.org/W2074938150","https://openalex.org/W2075588524","https://openalex.org/W2081582308","https://openalex.org/W2081941304","https://openalex.org/W2088488398","https://openalex.org/W2092848977","https://openalex.org/W2095439981","https://openalex.org/W2100238773","https://openalex.org/W2111066116","https://openalex.org/W2113353705","https://openalex.org/W2124256545","https://openalex.org/W2124886112","https://openalex.org/W2125452425","https://openalex.org/W2125701475","https://openalex.org/W2127699440","https://openalex.org/W2127809867","https://openalex.org/W2131629863","https://openalex.org/W2132565869","https://openalex.org/W2135398482","https://openalex.org/W2139488914","https://openalex.org/W2139981121","https://openalex.org/W2170215243","https://openalex.org/W2171317931","https://openalex.org/W2319590039","https://openalex.org/W2398782361","https://openalex.org/W2403780070","https://openalex.org/W2413090036","https://openalex.org/W2415374100","https://openalex.org/W2417050256","https://openalex.org/W2522404946","https://openalex.org/W2887702654","https://openalex.org/W4252808948","https://openalex.org/W4253234031","https://openalex.org/W7074066996"],"related_works":["https://openalex.org/W2042571016","https://openalex.org/W2919524689","https://openalex.org/W4243486559","https://openalex.org/W1979642189","https://openalex.org/W1983790053","https://openalex.org/W2055477207","https://openalex.org/W2024046142","https://openalex.org/W2030158623","https://openalex.org/W2004780049","https://openalex.org/W2049485751"],"abstract_inverted_index":{"The":[0,41,98,115,139,196,237],"goal":[1],"of":[2,17,30,38,43,51,64,100,117,144,178,190,198,204,239,250,265,288,334],"treatment":[3,19,146],"is":[4,20,24,46,61,105,123,133,141,302,315],"to":[5,47,76,108,208,283],"cure":[6,101,205],"whereas":[7],"maintaining":[8],"sphincter":[9,251],"function":[10],"and":[11,36,110,132,165,229,245,273,291,326,337],"minimizing":[12],"toxicity.":[13],"Although":[14],"the":[15,18,34,39,49,65,179,202,248,286,332],"mainstay":[16],"surgery,":[21],"radiotherapy":[22],"(RT)":[23],"used":[25],"in":[26,53,86],"a":[27,62,153,187,220,233,261],"substantial":[28],"proportion":[29],"patients":[31,54,71,318,340],"depending":[32],"on":[33,112,323],"location":[35,325],"extent":[37],"tumor.":[40],"aim":[42],"this":[44],"article":[45,60],"discuss":[48],"role":[50],"RT":[52,119,200,228,272,275,296,311,329],"with":[55,72,91,102,212,219,226,254,277,300,319,341],"resectable":[56,218],"rectal":[57,258,344],"adenocarcinoma.":[58],"This":[59],"review":[63],"pertinent":[66],"literature.":[67],"Results":[68],"show":[69],"that":[70,121,142,215],"T1N0":[73,320],"exophytic,":[74],"well":[75],"moderately":[77],"differentiated,":[78],"mobile":[79],"tumors":[80,214],"<":[81],"or":[82,95,172,298,312],"=":[83],"3":[84],"cm":[85],"diameter":[87],"may":[88,156,223,246,330],"be":[89,157,224],"treated":[90],"either":[92,103],"transanal":[93,163,221,313],"excision":[94,164,222,314],"endocavitary":[96,118],"RT.":[97],"probability":[99,264,333],"approach":[104],"approximately":[106],"80%":[107],"90%":[109],"depends":[111],"selection":[113],"criteria.":[114],"advantages":[116],"are":[120,148,216],"it":[122],"an":[124],"outpatient":[125],"procedure":[126],"requiring,":[127],"at":[128],"most,":[129],"local":[130,235],"anesthesia":[131],"suitable":[134,231,316],"for":[135,232,317,339],"elderly,":[136],"infirm":[137],"patients.":[138],"disadvantage":[140],"few":[143],"these":[145],"units":[147],"available.":[149],"Patients":[150,160,210,253],"who":[151,161],"experience":[152],"local-regional":[154,191,266,289,335],"recurrence":[155,192,267,290],"surgically":[158],"salvaged.":[159],"undergo":[162],"have":[166,186,260,280],"unfavorable":[167,213],"pathologic":[168],"findings":[169],"including":[170],"equivocal":[171],"close":[173],"margins,":[174],"poor":[175],"differentiation,":[176],"invasion":[177,185],"muscularis":[180],"propria,":[181],"and/or":[182,256],"endothelial-lined":[183],"space":[184],"high":[188,263],"risk":[189,287],"after":[193,268],"surgery":[194,269],"alone.":[195,270],"addition":[197,238],"postoperative":[199,274,306],"improves":[201],"likelihood":[203,249],"from":[206],"85%":[207],"90%.":[209],"presenting":[211],"borderline":[217],"downstaged":[225],"preoperative":[227,295],"rendered":[230],"wide":[234],"excision.":[236],"concomitant":[240],"chemotherapy":[241,279,301],"probably":[242],"enhances":[243],"downstaging":[244],"improve":[247,292,331],"preservation.":[252],"T3":[255],"N1":[257],"cancers":[259],"relatively":[262],"Preoperative":[271],"combined":[276,299],"adjuvant":[278,328],"been":[281],"shown":[282],"significantly":[284],"reduce":[285],"survival.":[293],"Whether":[294],"alone":[297],"more":[303],"efficacious":[304],"than":[305],"chemoradiation":[307],"remains":[308],"unclear.":[309],"Endocavitary":[310],"cancers.":[321],"Depending":[322],"tumor":[324],"extent,":[327],"control":[336],"survival":[338],"locally":[342],"advanced":[343],"adenocarcinomas.":[345]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
