{"id":"https://openalex.org/W2014902200","doi":"https://doi.org/10.1021/ac048722m","title":"Determination of Fractional Synthesis Rates of Mouse Hepatic Proteins via Metabolic 13C-Labeling, MALDI-TOF MS and Analysis of Relative Isotopologue Abundances Using Average Masses","display_name":"Determination of Fractional Synthesis Rates of Mouse Hepatic Proteins via Metabolic 13C-Labeling, MALDI-TOF MS and Analysis of Relative Isotopologue Abundances Using Average Masses","publication_year":2005,"publication_date":"2005-03-03","ids":{"openalex":"https://openalex.org/W2014902200","doi":"https://doi.org/10.1021/ac048722m","mag":"2014902200","pmid":"https://pubmed.ncbi.nlm.nih.gov/15801735"},"language":"en","primary_location":{"id":"doi:10.1021/ac048722m","doi":"https://doi.org/10.1021/ac048722m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac048722m","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020257591","display_name":"Josef Albert Vogt","orcid":"https://orcid.org/0000-0001-9190-3931","observed_orcids":["https://orcid.org/0000-0001-9190-3931","https://orcid.org/0000-0001-5860-8367"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef A. Vogt","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068544571","display_name":"Christian Hunzinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Hunzinger","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059028860","display_name":"Klaus Schroer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Schroer","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027993034","display_name":"Kerstin H\u00f6lzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin H\u00f6lzer","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anke Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anke Bauer","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036602289","display_name":"Andr\u00e9 St. Schrattenholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Schrattenholz","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061438971","display_name":"Michael A. Cahill","orcid":"https://orcid.org/0000-0002-8593-8844","observed_orcids":["https://orcid.org/0000-0002-8593-8844"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael A. Cahill","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014401117","display_name":"Simone Schillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone Schillo","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060735886","display_name":"Gerhard Schwall","orcid":"https://orcid.org/0000-0001-5046-1225","observed_orcids":["https://orcid.org/0000-0001-5046-1225"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerhard Schwall","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080501190","display_name":"Werner Stegmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Werner Stegmann","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047954550","display_name":"Gerd Albuszies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd Albuszies","raw_affiliation_strings":["Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum f\u00fcr An\u00e4sthesiologie, Universit\u00e4t Ulm, Sektion APV, Parkstrasse 11, 89075 Ulm, Germany, and ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080501190"],"corresponding_institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.7955,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.83675885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"77","issue":"7","first_page":"2034","last_page":"2042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractional-synthesis-rate","display_name":"fractional synthesis rate","score":0.847000002861023},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.7160000205039978},{"id":"https://openalex.org/keywords/liver-proteome","display_name":"liver proteome","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8984732031822205},{"id":"https://openalex.org/C13934619","wikidata":"https://www.wikidata.org/wiki/Q2198720","display_name":"Isotopologue","level":3,"score":0.8426189422607422},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5930951833724976},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5838645696640015},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5289350152015686},{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.5278030633926392},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.48771724104881287},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.4758948087692261},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4368383586406708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39243075251579285},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.09802258014678955},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005591","descriptor_name":"Chemical Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ac048722m","doi":"https://doi.org/10.1021/ac048722m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac048722m","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:15801735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15801735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1226960292","https://openalex.org/W1493532528","https://openalex.org/W1921083320","https://openalex.org/W1972338781","https://openalex.org/W2012704670","https://openalex.org/W2014919990","https://openalex.org/W2017259594","https://openalex.org/W2029423424","https://openalex.org/W2038526453","https://openalex.org/W2052998622","https://openalex.org/W2071119989","https://openalex.org/W2079151410","https://openalex.org/W2082416572","https://openalex.org/W2098957689","https://openalex.org/W2150123812","https://openalex.org/W2168113735","https://openalex.org/W2182499111","https://openalex.org/W2417273358","https://openalex.org/W2596499844"],"related_works":["https://openalex.org/W6921395867","https://openalex.org/W4386863606","https://openalex.org/W2009039683","https://openalex.org/W4399356023","https://openalex.org/W2100903963","https://openalex.org/W2066299293","https://openalex.org/W3017244023","https://openalex.org/W108214297","https://openalex.org/W2955035326","https://openalex.org/W2512993038"],"abstract_inverted_index":{"Proteins":[0],"of":[1,27,34,53,58,76,113,141,143],"a":[2,7,144],"liver":[3,164],"extract":[4],"taken":[5],"from":[6,80,93,103,120,176],"metabolically":[8],"(13)C-labeled":[9],"mouse":[10],"were":[11,78,116],"separated":[12],"by":[13,20,31,63],"2D-PAGE":[14],"and":[15,61],"identified":[16],"after":[17],"tryptic":[18,59],"digestion":[19],"MALDI-TOF":[21],"MS":[22],"peptide":[23],"mass":[24,70],"fingerprinting.":[25],"(13)C-Labeling":[26],"proteins":[28,77,104,115],"was":[29,46,101],"achieved":[30],"an":[32,157],"infusion":[33],"U-(13)C-glucose,":[35],"which":[36,98,136,177],"is":[37],"metabolized":[38],"to":[39,118,124],"labeled":[40],"nonessential":[41],"amino":[42,95],"acids.":[43],"The":[44,109,150],"labeling":[45],"analyzed":[47],"using":[48,83],"the":[49,54,67,139,163],"relative":[50],"isotopologue":[51],"abundances":[52],"measured":[55,84],"isotope":[56],"pattern":[57],"peptides":[60,82,142],"quantified":[62],"their":[64],"increase":[65],"in":[66,99,162],"average":[68],"molecular":[69],"(DeltaAVM).":[71],"Fractional":[72],"synthesis":[73],"rates":[74],"(FSR)":[75],"determined":[79,117],"corresponding":[81],"DeltaAVM":[85,90],"values":[86,91,112,155,175],"as":[87,89,133,156],"well":[88],"deduced":[92],"tRNA-precursor":[94],"acid":[96],"labeling,":[97],"turn":[100],"derived":[102],"showing":[105],"high":[106,184],"(13)C":[107],"enrichments.":[108],"8-h":[110],"FSR":[111,154],"43":[114],"range":[119],"0":[121],"+/-":[122,126],"0.6":[123],"95":[125],"1%/8":[127],"h,":[128],"with":[129,183],"typical":[130],"errors":[131],"given":[132],"SEM":[134],"values,":[135],"depend":[137],"on":[138],"number":[140],"specific":[145],"protein":[146,160],"usable":[147],"for":[148,159],"calculation.":[149],"method":[151],"demonstrates":[152],"that":[153],"indicator":[158],"turnover":[161],"proteome":[165],"can":[166],"be":[167,181],"estimated":[168],"within":[169],"narrow":[170],"error":[171],"margins,":[172],"providing":[173],"baseline":[174],"treatment-dependent":[178],"deviations":[179],"could":[180],"detected":[182],"statistical":[185],"certainty.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
