{"id":"https://openalex.org/W2014900438","doi":"https://doi.org/10.1002/hup.470070104","title":"Acute effects of hydroxyzine on nocturnal sleep and sleep tendency the following day: A C\u2010EEG study","display_name":"Acute effects of hydroxyzine on nocturnal sleep and sleep tendency the following day: A C\u2010EEG study","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2014900438","doi":"https://doi.org/10.1002/hup.470070104","mag":"2014900438"},"language":"en","primary_location":{"id":"doi:10.1002/hup.470070104","doi":"https://doi.org/10.1002/hup.470070104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hup.470070104","pdf_url":null,"source":{"id":"https://openalex.org/S154207414","display_name":"Human Psychopharmacology Clinical and Experimental","issn_l":"0885-6222","issn":["0885-6222","1099-1077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Psychopharmacology: Clinical and Experimental","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074215328","display_name":"Chris Alford","orcid":"https://orcid.org/0000-0003-0887-6958","observed_orcids":["https://orcid.org/0000-0003-0887-6958"]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"C. Alford","raw_affiliation_strings":["Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035137530","display_name":"N. Rombaut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. Rombaut","raw_affiliation_strings":["Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Jones","raw_affiliation_strings":["Interphase UK, Interphase House, I London Road, Hindhead, Surrey GU26 6AB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interphase UK, Interphase House, I London Road, Hindhead, Surrey GU26 6AB, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Foley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Foley","raw_affiliation_strings":["Interphase UK, Interphase House, I London Road, Hindhead, Surrey GU26 6AB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interphase UK, Interphase House, I London Road, Hindhead, Surrey GU26 6AB, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039023883","display_name":"Chris Idzikowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Idzikowski","raw_affiliation_strings":["Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK","institution_ids":["https://openalex.org/I28290843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108291971","display_name":"I. Hindmarch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28290843","display_name":"University of Surrey","ror":"https://ror.org/00ks66431","country_code":"GB","type":"education","lineage":["https://openalex.org/I28290843"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Hindmarch","raw_affiliation_strings":["Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Psychopharmacology Research Unit, Robens Institute of Health and Safety, University of Surrey, Guildford, GU2 5XH, UK","institution_ids":["https://openalex.org/I28290843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074215328"],"corresponding_institution_ids":["https://openalex.org/I28290843"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":3.2837,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.92971939,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"1","first_page":"25","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyzine","display_name":"hydroxyzine","score":1.0},{"id":"https://openalex.org/keywords/hypnotic-effects","display_name":"hypnotic effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nocturnal-sleep","display_name":"nocturnal sleep","score":0.878000020980835},{"id":"https://openalex.org/keywords/sleep-onset-latency","display_name":"sleep latency","score":0.9660000205039978},{"id":"https://openalex.org/keywords/sleep-duration","display_name":"sleep duration","score":0.8339999914169312},{"id":"https://openalex.org/keywords/daytime-sleepiness","display_name":"daytime sleepiness","score":0.878000020980835},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6620000004768372},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5429999828338623},{"id":"https://openalex.org/keywords/hangover-effects","display_name":"hangover effects","score":0.7179999947547913},{"id":"https://openalex.org/keywords/continuous-eeg-monitoring","display_name":"continuous EEG monitoring","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2776246316","wikidata":"https://www.wikidata.org/wiki/Q421937","display_name":"Hydroxyzine","level":2,"score":0.7746511697769165},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.6775398254394531},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.6316471099853516},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5931416749954224},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.5827637314796448},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.560710072517395},{"id":"https://openalex.org/C63759246","wikidata":"https://www.wikidata.org/wiki/Q7539762","display_name":"Sleep onset","level":3,"score":0.5044494867324829},{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.4936281442642212},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48284369707107544},{"id":"https://openalex.org/C192769605","wikidata":"https://www.wikidata.org/wiki/Q1418914","display_name":"Vigilance (psychology)","level":2,"score":0.46897634863853455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46594440937042236},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.44991135597229004},{"id":"https://openalex.org/C2781053850","wikidata":"https://www.wikidata.org/wiki/Q7539763","display_name":"Sleep onset latency","level":4,"score":0.44033578038215637},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.43436288833618164},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.41091763973236084},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.296474426984787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2154843807220459},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10175111889839172},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06925785541534424},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/hup.470070104","doi":"https://doi.org/10.1002/hup.470070104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hup.470070104","pdf_url":null,"source":{"id":"https://openalex.org/S154207414","display_name":"Human Psychopharmacology Clinical and Experimental","issn_l":"0885-6222","issn":["0885-6222","1099-1077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Psychopharmacology: Clinical and Experimental","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W4475463","https://openalex.org/W1898430231","https://openalex.org/W1913557665","https://openalex.org/W1966764350","https://openalex.org/W1971962272","https://openalex.org/W1989314580","https://openalex.org/W1993287004","https://openalex.org/W1998609266","https://openalex.org/W2005580357","https://openalex.org/W2011333937","https://openalex.org/W2020047799","https://openalex.org/W2025014022","https://openalex.org/W2035041462","https://openalex.org/W2035569274","https://openalex.org/W2041447343","https://openalex.org/W2043610697","https://openalex.org/W2055220982","https://openalex.org/W2078657146","https://openalex.org/W2081630005","https://openalex.org/W2104312285","https://openalex.org/W2134654456","https://openalex.org/W2163021858","https://openalex.org/W2223792193","https://openalex.org/W2284301704","https://openalex.org/W2409487943","https://openalex.org/W2414303156","https://openalex.org/W2417911099","https://openalex.org/W3022302886","https://openalex.org/W4251491114","https://openalex.org/W4252347102"],"related_works":["https://openalex.org/W2331494066","https://openalex.org/W2039998284","https://openalex.org/W2405227985","https://openalex.org/W2002684465","https://openalex.org/W2035569274","https://openalex.org/W2004288951","https://openalex.org/W1981446524","https://openalex.org/W2415306416","https://openalex.org/W4322207737","https://openalex.org/W2046373046"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"acute":[2],"hypnotic":[3,67,130],"effects":[4,106],"of":[5,93,132],"hydroxyzine":[6,133],"25":[7],"mg":[8,11],"and":[9,18,33,48,121],"50":[10],"nocte,":[12],"were":[13,26,59,84,113],"examined":[14],"in":[15,44,50,56,73,78,144],"six":[16,19],"male":[17],"female":[20,88,118],"volunteers.":[21],"Continuous":[22],"electrophysiological":[23],"measures":[24,92],"(C\u2010EEG)":[25],"taken":[27],"to":[28,100,136,146],"assess":[29],"both":[30,82],"nocturnal":[31],"sleep":[32,34,45,57,74,79],"tendency":[35],"the":[36,87,96,104,117,129,153],"following":[37,81,97],"day.":[38],"Both":[39],"doses":[40,83],"produced":[41],"significant":[42,85,138],"reductions":[43],"onset":[46,75],"latency":[47],"decreases":[49],"waking":[51],"during":[52],"sleep;":[53],"reciprocal":[54],"increases":[55],"duration":[58,80],"also":[60],"seen.":[61],"Female":[62],"subjects":[63],"demonstrated":[64],"a":[65,70],"greater":[66],"response,":[68],"including":[69,110],"dose\u2010dependent":[71,111],"decrease":[72],"latency.":[76],"Increases":[77],"for":[86],"group":[89,120],"alone.":[90],"C\u2010EEG":[91,139],"increased":[94],"drowsiness":[95],"day":[98],"failed":[99],"achieve":[101],"significance;":[102],"although":[103],"largest":[105],"on":[107],"daytime":[108],"sleepiness,":[109],"increases,":[112],"again":[114],"seen":[115],"with":[116,123],"subject":[119],"corresponded":[122],"subjective":[124],"ratings.":[125],"These":[126],"results":[127],"demonstrate":[128],"efficacy":[131],"whilst":[134],"failing":[135],"detect":[137],"hangover":[140],"effects.":[141],"However,":[142],"variability":[143],"response":[145],"antihistamines,":[147],"registered":[148],"here":[149],"as":[150],"differences":[151],"between":[152],"sexes,":[154],"requires":[155],"further":[156],"consideration.":[157]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}