{"id":"https://openalex.org/W2014899713","doi":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","title":"Influences of angiogenesis and lymphangiogenesis on cancerous invasion in experimentally induced tongue carcinoma","display_name":"Influences of angiogenesis and lymphangiogenesis on cancerous invasion in experimentally induced tongue carcinoma","publication_year":2005,"publication_date":"2005-01-10","ids":{"openalex":"https://openalex.org/W2014899713","doi":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","mag":"2014899713","pmid":"https://pubmed.ncbi.nlm.nih.gov/15641987"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0714.2004.00279.x","doi":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology & Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014082008","display_name":"Hiromitsu Nakaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiromitsu Nakaya","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan. h-nakaya@oral.m.kanazawa-u.ac.jp","Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan. h-nakaya@oral.m.kanazawa-u.ac.jp","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110245467","display_name":"Shuichi Kawashiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Kawashiri","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061345986","display_name":"Akira Tanaka","orcid":"https://orcid.org/0000-0001-8967-7445","observed_orcids":["https://orcid.org/0000-0001-8967-7445"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Tanaka","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111531854","display_name":"Natsuyo Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Natsuyo Noguchi","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015834932","display_name":"Koroku Kato","orcid":"https://orcid.org/0000-0003-3026-662X","observed_orcids":["https://orcid.org/0000-0003-3026-662X"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koroku Kato","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Hase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Hase","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113527624","display_name":"Etsuhide Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Etsuhide Yamamoto","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Division of Cancer Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014082008"],"corresponding_institution_ids":["https://openalex.org/I10091056"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":2.0676,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86435068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"34","issue":"2","first_page":"87","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lymphangiogenesis","display_name":"lymphangiogenesis","score":1.0},{"id":"https://openalex.org/keywords/tongue-cancer","display_name":"tongue cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lymphatic-vessel-density","display_name":"lymphatic vessel density","score":0.6629999876022339},{"id":"https://openalex.org/keywords/blood-vessel-density","display_name":"blood vessel density","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vegf-c","display_name":"VEGF-C","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dmba-induced-carcinogenesis","display_name":"DMBA-induced carcinogenesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7608264684677124},{"id":"https://openalex.org/C2776636583","wikidata":"https://www.wikidata.org/wiki/Q6708231","display_name":"Lymphangiogenesis","level":4,"score":0.7594436407089233},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.7104268074035645},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.699217677116394},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.6634373068809509},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.5614284873008728},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5388348698616028},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47562769055366516},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4745691120624542},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4716595411300659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42366528511047363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38716864585876465},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.34784016013145447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16331923007965088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12756448984146118}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014062","descriptor_name":"Tongue Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D014062","descriptor_name":"Tongue Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014062","descriptor_name":"Tongue Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015127","descriptor_name":"9,10-Dimethyl-1,2-benzanthracene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042582","descriptor_name":"Vascular Endothelial Growth Factor C","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042583","descriptor_name":"Lymphangiogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0714.2004.00279.x","doi":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0714.2004.00279.x","pdf_url":null,"source":{"id":"https://openalex.org/S86809486","display_name":"Journal of Oral Pathology and Medicine","issn_l":"0300-9777","issn":["0300-9777","0904-2512","1600-0714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oral Pathology & Medicine","raw_type":"journal-article"},{"id":"pmid:15641987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15641987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1527031583","https://openalex.org/W1570971207","https://openalex.org/W1792542720","https://openalex.org/W1885629825","https://openalex.org/W1972341325","https://openalex.org/W1997814847","https://openalex.org/W2008691375","https://openalex.org/W2009526729","https://openalex.org/W2017174424","https://openalex.org/W2018442334","https://openalex.org/W2020276815","https://openalex.org/W2025173623","https://openalex.org/W2025857570","https://openalex.org/W2028878523","https://openalex.org/W2047365643","https://openalex.org/W2057236747","https://openalex.org/W2072106622","https://openalex.org/W2084086998","https://openalex.org/W2099011923","https://openalex.org/W2103470533","https://openalex.org/W2107469156","https://openalex.org/W2126805364","https://openalex.org/W2129081579","https://openalex.org/W2133247973","https://openalex.org/W2154052357","https://openalex.org/W2332529870","https://openalex.org/W2397088309","https://openalex.org/W3134137428","https://openalex.org/W4211002736","https://openalex.org/W4300179601"],"related_works":["https://openalex.org/W162467250","https://openalex.org/W2129854164","https://openalex.org/W1596186816","https://openalex.org/W2381651516","https://openalex.org/W2106377417","https://openalex.org/W1597954052","https://openalex.org/W2229150347","https://openalex.org/W1982235749","https://openalex.org/W2056914139","https://openalex.org/W2288109230"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"it":[2,13],"is":[3,14],"clear":[4],"that":[5,147,221],"dissemination":[6],"via":[7],"the":[8,45,52,78,82,106,135,156,170,179],"blood":[9,38,115,136,148,180],"system":[10],"involves":[11],"angiogenesis,":[12],"uncertain":[15],"whether":[16],"tumors":[17],"also":[18],"induce":[19],"lymphangiogenesis":[20,224],"or":[21],"simply":[22],"invade":[23],"existing":[24],"peritumoral":[25],"vessels.":[26],"The":[27,132,144,201,217],"purpose":[28],"of":[29,47,81,84,169,172,203],"this":[30],"study":[31],"was":[32,74,208],"to":[33,189],"elucidate":[34],"changes":[35],"in":[36,42,51,63,67,99,155,161,167,192,197],"tumor":[37,176,194,199,213],"and":[39,55,59,92,114,125,138,149,223],"lymph":[40,60,126,139,150,185],"vessels":[41,61,116,127,137,140],"cases":[43],"involving":[44],"invasion":[46,177,195,214],"squamous":[48],"cell":[49],"carcinoma":[50,158],"oral":[53],"cavity,":[54],"its":[56],"significance.":[57],"Blood":[58],"densities":[62,152],"tongue":[64,83],"carcinomas":[65],"induced":[66,75],"hamsters":[68],"were":[69,112,141,153,165],"investigated.":[70],"METHODS:":[71],"Tongue":[72],"cancer":[73,173],"by":[76,119,227],"abrading":[77],"right":[79],"margin":[80],"each":[85],"hamster":[86],"with":[87,121],"an":[88],"endodontic":[89],"barbed":[90],"broach":[91],"subsequently":[93],"applying":[94],"1.0%":[95],"9,10-dimenthl-1,2-benzanthracene":[96],"(DMBA)":[97],"dissolved":[98],"acetone,":[100],"three":[101],"times":[102],"a":[103],"week,":[104],"at":[105],"same":[107],"site.":[108],"Fresh":[109],"frozen":[110],"sections":[111],"prepared":[113],"stained":[117,128],"blue":[118],"perfusion":[120],"Coomassie":[122],"Brilliant":[123],"Blue":[124],"brown":[129],"for":[130],"5'-nucleotidase.":[131],"effects":[133],"on":[134],"observed.":[142],"RESULTS:":[143],"results":[145],"showed":[146],"vessel":[151,181,186],"greater":[154],"advanced":[157],"tissues":[159],"than":[160,196],"normal":[162],"tissue.":[163],"These":[164],"compared":[166],"terms":[168],"mode":[171],"invasion.":[174,200,229],"As":[175],"progressed,":[178],"density":[182,187],"decreased":[183],"but":[184],"tended":[188],"be":[190],"higher":[191],"high-degree":[193],"low-degree":[198],"expression":[202],"vascular":[204],"endothelial":[205],"growth":[206],"factor-C":[207],"seen":[209],"more":[210],"frequently":[211],"as":[212],"progressed.":[215],"CONCLUSIONS:":[216],"present":[218],"findings":[219],"indicated":[220],"angiogenesis":[222],"are":[225],"affected":[226],"cancerous":[228]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}