{"id":"https://openalex.org/W2014896785","doi":"https://doi.org/10.1097/00005072-199909000-00004","title":"Hypoxemia Near Mid-Gestation Has Long-term Effects on Fetal Brain Development","display_name":"Hypoxemia Near Mid-Gestation Has Long-term Effects on Fetal Brain Development","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2014896785","doi":"https://doi.org/10.1097/00005072-199909000-00004","mag":"2014896785","pmid":"https://pubmed.ncbi.nlm.nih.gov/10499436"},"language":"en","primary_location":{"id":"doi:10.1097/00005072-199909000-00004","doi":"https://doi.org/10.1097/00005072-199909000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-199909000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073916533","display_name":"Sandra M. Rees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"S. Rees","raw_affiliation_strings":["Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria, Australia","*Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"*Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050232793","display_name":"Sibilah J. Breen","orcid":"https://orcid.org/0000-0001-9896-004X","observed_orcids":["https://orcid.org/0000-0001-9896-004X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Breen","raw_affiliation_strings":["Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria","Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004126768","display_name":"Michelle M. Loeliger","orcid":"https://orcid.org/0000-0002-2163-1819","observed_orcids":["https://orcid.org/0000-0002-2163-1819"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Loeliger","raw_affiliation_strings":["Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria","Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Cell Biology, University of Melbourne, Parkville, Victoria","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101272","display_name":"G. J. McCrabb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"G. McCrabb","raw_affiliation_strings":["Department of Physiology, Monash University, Clayton, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Monash University, Clayton, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086923376","display_name":"Richard Harding","orcid":"https://orcid.org/0000-0001-9653-8689","observed_orcids":["https://orcid.org/0000-0001-9653-8689"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"R. Harding","raw_affiliation_strings":["Department of Physiology, Monash University, Clayton, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Monash University, Clayton, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073916533"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":4.5297,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.94132372,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"58","issue":"9","first_page":"932","last_page":"945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-hypoxemia","display_name":"fetal hypoxemia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/second-trimester","display_name":"second trimester","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fetal-brain-development","display_name":"fetal brain development","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.6010000109672546},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.984000027179718},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.7770000100135803},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.6069999933242798},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.7900000214576721},{"id":"https://openalex.org/keywords/placental-ischemia","display_name":"placental ischemia","score":0.5529999732971191},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.38499999046325684},{"id":"https://openalex.org/keywords/neurodevelopmental-damage","display_name":"neurodevelopmental damage","score":0.5600000023841858},{"id":"https://openalex.org/keywords/acidemia","display_name":"acidemia","score":0.4650000035762787},{"id":"https://openalex.org/keywords/vascular-clamps","display_name":"vascular clamps","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.8339500427246094},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.7755656242370605},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.512031614780426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45577147603034973},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.4172874987125397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3922465741634369},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34685972332954407},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3389214873313904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33811962604522705},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2337610423564911},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004676","descriptor_name":"Myelin Basic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005740","descriptor_name":"Gases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011270","descriptor_name":"Pregnancy, Animal","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005072-199909000-00004","doi":"https://doi.org/10.1097/00005072-199909000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005072-199909000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology &amp; Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:10499436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10499436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035354480","https://openalex.org/W2011497491","https://openalex.org/W2084744251","https://openalex.org/W2428434797","https://openalex.org/W2041651810","https://openalex.org/W7099409986","https://openalex.org/W2908911486","https://openalex.org/W1996797052","https://openalex.org/W2095198405","https://openalex.org/W1507653344"],"abstract_inverted_index":{"We":[0,271],"tested":[1],"the":[2,22,31,41,44,65,70,97,121,125,139,143,156,167,175,178,183,186,193,196,202,213,224,230,237,252,267,284,292,309,317,332,335,343,347,351],"hypotheses":[3],"that":[4,21,273],"an":[5,274,313],"episode":[6,275],"of":[7,26,33,43,127,133,142,155,158,170,177,185,195,215,217,232,240,255,269,276,297,316,319,334,346],"hypoxemia":[8,277,310],"near":[9,278],"mid-gestation":[10,279],"in":[11,117,138,146,165,212,223,229,251,266,283,291,300,342],"fetal":[12,84],"sheep":[13,47],"has":[14],"long-term":[15],"effects":[16],"on":[17],"brain":[18,38,113,366],"development":[19,34,327],"and":[20,24,96,101,200,228,259,286,288,363],"extent":[23],"type":[25],"damage":[27,114],"is":[28,328,340,353],"related":[29],"to":[30,69,82],"stage":[32,315],"within":[35],"a":[36,77,131,245,260,301],"particular":[37,302],"structure":[39],"at":[40,54,312,331],"time":[42,333],"hypoxemia.":[45,128],"Fetal":[46],"(n":[48,105],"=":[49,106],"8)":[50,107],"were":[51,91,108,163,208],"made":[52],"hypoxemic":[53,147,159,241],"90":[55],"+/-":[56],"2":[57],"days":[58,94],"(term":[59],"approximately":[60],"147":[61],"days)":[62],"by":[63,88],"restricting":[64],"maternal":[66],"blood":[67],"supply":[68],"placenta":[71],"for":[72],"12":[73],"hours":[74],"(h)":[75],"using":[76],"vascular":[78],"clamp":[79],"so":[80],"as":[81,110],"reduce":[83],"arterial":[85],"O2":[86],"saturation":[87],"50%-60%.":[89],"Fetuses":[90],"killed":[92],"35":[93],"later":[95],"brains":[98],"analysed":[99],"histologically":[100],"immunohistochemically.":[102],"Age-matched":[103],"fetuses":[104,148],"used":[109],"controls.":[111,151],"Gross":[112],"was":[115,130,244],"observed":[116],"only":[118],"1":[119],"fetus,":[120],"most":[122],"acidemic":[123],"during":[124],"period":[126],"There":[129,207],"reduction":[132,247],"12%":[134],"(p":[135,248,263],"<":[136,249,264],"0.05)":[137,250],"cross-sectional":[140,204],"area":[141,184,194,205,214],"cerebral":[144,293,348],"cortex":[145],"compared":[149],"with":[150],"In":[152,236],"lobule":[153],"6":[154],"cerebella":[157],"fetuses,":[160,242],"significant":[161,210],"reductions":[162,211],"seen":[164],"(a)":[166],"volume":[168,253],"density":[169,226,254],"Purkinje":[171,218],"cells":[172,258],"(33%),":[173],"(b)":[174],"width":[176],"molecular":[179],"layer":[180,190],"(13%),":[181,191],"(c)":[182],"inner":[187],"granule":[188],"cell":[189,219],"(d)":[192],"white":[197,344],"matter":[198,345],"(18%),":[199],"(e)":[201],"total":[203],"(15%).":[206],"also":[209,290],"arborization":[216],"dendritic":[220,233],"trees":[221],"(50%),":[222],"branching":[225],"(25%),":[227],"number":[231,268],"spines":[234],"(31%).":[235],"ventral":[238],"hippocampi":[239],"there":[243],"36%":[246],"CA1":[256],"pyramidal":[257],"50%":[261],"increase":[262],"0.05%)":[265],"astrocytes.":[270],"conclude":[272],"reduces":[280],"neuronal":[281],"numbers":[282],"hippocampus":[285],"cerebellum":[287],"probably":[289],"cortex.":[294],"The":[295],"growth":[296,318],"neural":[298,320,361],"processes":[299,321],"region":[303],"will":[304],"be":[305],"significantly":[306],"retarded":[307],"if":[308,326,350],"occurs":[311],"early":[314],"(e.g.":[322,337],"cerebellum)":[323],"but":[324],"not":[325],"well":[329],"advanced":[330],"insult":[336,352],"hippocampus).":[338],"Damage":[339],"sustained":[341],"hemispheres":[349],"particularly":[354],"severe.":[355],"Together,":[356],"these":[357],"deficits":[358],"could":[359],"affect":[360],"connectivity":[362],"impair":[364],"postnatal":[365],"function.":[367]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
