{"id":"https://openalex.org/W2014894774","doi":"https://doi.org/10.1161/01.res.35.4.544","title":"Increased Metabolic Turnover Rate and Transcapillary Escape Rate of Albumin in Essential Hypertension","display_name":"Increased Metabolic Turnover Rate and Transcapillary Escape Rate of Albumin in Essential Hypertension","publication_year":1974,"publication_date":"1974-10-01","ids":{"openalex":"https://openalex.org/W2014894774","doi":"https://doi.org/10.1161/01.res.35.4.544","mag":"2014894774","pmid":"https://pubmed.ncbi.nlm.nih.gov/4413836"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.35.4.544","doi":"https://doi.org/10.1161/01.res.35.4.544","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.35.4.544","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.35.4.544?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.35.4.544?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111749912","display_name":"Hans\u2010Henrik Parving","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"HANS-HENRIK PARVING","raw_affiliation_strings":["Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904"]}]},{"author_position":"middle","author":{"id":null,"display_name":"NIELS ROSSING","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"NIELS ROSSING","raw_affiliation_strings":["Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102100058","display_name":"H. \u00c6. Jensen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801941904","display_name":"Bispebjerg Hospital","ror":"https://ror.org/00td68a17","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801941904","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"HENRIK AE. JENSEN","raw_affiliation_strings":["Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Physiology, Bispebjerg Hospital, and Medical Department C, Diakonissestiftelsen Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801941904"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801941904"],"apc_list":null,"apc_paid":null,"fwci":5.3218,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94973989,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"35","issue":"4","first_page":"544","last_page":"552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.9909999966621399},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/transcapillary-escape-rate","display_name":"transcapillary escape rate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/albumin-synthesis","display_name":"albumin synthesis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fractional-catabolic-rate","display_name":"fractional catabolic rate","score":0.8370000123977661},{"id":"https://openalex.org/keywords/plasma-volume","display_name":"plasma volume","score":0.7110000252723694},{"id":"https://openalex.org/keywords/capillary-filtration","display_name":"capillary filtration","score":0.6449999809265137},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.8852293491363525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.667586088180542},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6006004214286804},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4919252395629883},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.47944775223731995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449229836463928},{"id":"https://openalex.org/C2991747820","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Plasma volume","level":2,"score":0.4323861300945282},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4228944480419159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.334342360496521}],"mesh":[{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001830","descriptor_name":"Body Surface Area","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010953","descriptor_name":"Plasma Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012711","descriptor_name":"Serum Albumin, Radio-Iodinated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.res.35.4.544","doi":"https://doi.org/10.1161/01.res.35.4.544","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.35.4.544","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.35.4.544?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:4413836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4413836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/01.res.35.4.544","doi":"https://doi.org/10.1161/01.res.35.4.544","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.35.4.544","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.35.4.544?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014894774.pdf","grobid_xml":"https://content.openalex.org/works/W2014894774.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1904555916","https://openalex.org/W1974366694","https://openalex.org/W1981224373","https://openalex.org/W1990986783","https://openalex.org/W1995706927","https://openalex.org/W2004266110","https://openalex.org/W2018938367","https://openalex.org/W2032828707","https://openalex.org/W2035037001","https://openalex.org/W2049489253","https://openalex.org/W2067477712","https://openalex.org/W2086687531","https://openalex.org/W2264075669","https://openalex.org/W2275904155","https://openalex.org/W2303753749","https://openalex.org/W2333481886","https://openalex.org/W2336763502","https://openalex.org/W2356461784","https://openalex.org/W2399792513","https://openalex.org/W2404350116","https://openalex.org/W2405491199","https://openalex.org/W2417016079","https://openalex.org/W2484386448","https://openalex.org/W2496979616"],"related_works":["https://openalex.org/W1981444304","https://openalex.org/W2130260569","https://openalex.org/W2318184211","https://openalex.org/W2062472250","https://openalex.org/W2171003223","https://openalex.org/W2096342453","https://openalex.org/W2040705281","https://openalex.org/W2553182165","https://openalex.org/W2037433140","https://openalex.org/W2163212043"],"abstract_inverted_index":{"The":[0,26,122,148],"metabolic":[1,117],"turnover":[2],"rate":[3,8,118,149,196,234,270,275],"and":[4,237,271],"the":[5,64,70,79,87,134,193,205,231,255,267,272,285,297],"transcapillary":[6,194,232,268],"escape":[7,195,233,269],"of":[9,32,74,100,115,124,142,150,163,197,200,215,235,276],"albumin":[10,17,47,72,84,116,126,175,182,198,236,277,288],"were":[11],"studied":[12],"using":[13],"131":[14],"I-labeled":[15],"human":[16],"in":[18,60,69,86,119,192,291],"nine":[19],"untreated":[20],"subjects":[21,34,40,76],"suffering":[22],"from":[23,211],"essential":[24,120],"hypertension.":[25,121],"average":[27,80,135,214],"mean":[28],"arterial":[29,257],"blood":[30,238,258],"pressure":[31,239],"these":[33,61],"was":[35,49,54,77,90,111,132,152,177,224,261],"162/109":[36],"mm":[37],"Hg;":[38],"seven":[39],"had":[41],"grade":[42],"I-II":[43],"funduscopic":[44],"changes.":[45],"Plasma":[46],"concentration":[48],"normal,":[50],"but":[51],"plasma":[52],"volume":[53],"reduced":[55],"(":[56,240,278],"P":[57,105,145,170,220,241,279],"<":[58,106,146,171,221,242,280],"0.05)":[59],"subjects.":[62],"Thus,":[63],"previously":[65],"reported":[66],"moderate":[67],"decrease":[68],"intravascular":[71,83,125,181,201],"mass":[73,85,127,176,202],"hypertensive":[75],"confirmed;":[78],"value":[81,99,141,162],"for":[82],"present":[88],"study":[89],"62.8":[91],"g/m2":[92],"surface":[93],"area":[94],"compared":[95,137,158],"with":[96,138,159,293],"a":[97,112,139,160,185,212,225,263],"normal":[98,140,161,213],"70.6":[101],"g/m":[102],"2":[103],"(-11%,":[104],"0.05).":[107,243,281],"A":[108],"surprising":[109],"finding":[110,283],"marked":[113],"enhancement":[114],"fraction":[123],"metabolized":[128],"per":[129,208],"24-hour":[130],"period":[131],"on":[133],"14.4%":[136],"8.4%":[143],"(+72%,":[144],"0.001).":[147,172,222],"synthesis":[151],"9.1":[153],"g/24":[154,165],"hours":[155,166],"m":[156,167],"-2":[157,168],"5.9":[164],"(+54%,":[169],"Total":[173],"body":[174],"decreased":[178],"proportionally":[179],"to":[180,204,217,254],"mass.":[183],"Confirming":[184],"previous":[186],"observation,":[187],"we":[188],"found":[189],"an":[190],"increase":[191],"(fraction":[199],"passing":[203],"extravascular":[206],"space":[207],"unit":[209],"time)":[210],"5.6%/hour":[216],"7.5%/hour":[218],"(+34%,":[219],"There":[223,260],"statistically":[226],"significant":[227],"positive":[228,264],"correlation":[229,265],"between":[230,266],"These":[244],"findings":[245],"can":[246],"best":[247],"be":[248],"explained":[249],"by":[250],"increased":[251],"filtration":[252],"due":[253],"high":[256],"pressure.":[259],"also":[262],"fractional":[273],"catabolic":[274],"This":[282],"supports":[284],"concept":[286],"that":[287],"is":[289],"catabolized":[290],"connection":[292],"its":[294],"permeation":[295],"through":[296],"capillary":[298],"endothelium.":[299]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
