{"id":"https://openalex.org/W2014891128","doi":"https://doi.org/10.1056/nejm198506063122309","title":"Combined-Modality Therapy of Cancer","display_name":"Combined-Modality Therapy of Cancer","publication_year":1985,"publication_date":"1985-06-06","ids":{"openalex":"https://openalex.org/W2014891128","doi":"https://doi.org/10.1056/nejm198506063122309","mag":"2014891128","pmid":"https://pubmed.ncbi.nlm.nih.gov/3990752"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198506063122309","doi":"https://doi.org/10.1056/nejm198506063122309","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198506063122309","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072133376","display_name":"Steven A. Rosenberg","orcid":"https://orcid.org/0000-0002-8939-8910","observed_orcids":["https://orcid.org/0000-0002-8939-8910"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steven A. Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072133376"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"312","issue":"23","first_page":"1512","last_page":"1514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3003000020980835,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13123","display_name":"Advances in Oncology and Radiotherapy","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.0835999995470047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-control","display_name":"tumor control","score":0.4390000104904175},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/organ-preserving-surgery","display_name":"organ-preserving surgery","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6537154316902161},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6035345792770386},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.5802351832389832},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.5192247033119202},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.49283266067504883},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4330151677131653},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41554027795791626},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37203431129455566},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3568944036960602},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33360856771469116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19030648469924927},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16035884618759155},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06852319836616516}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm198506063122309","doi":"https://doi.org/10.1056/nejm198506063122309","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198506063122309","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:3990752","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3990752","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W562473934","https://openalex.org/W2418936134","https://openalex.org/W3152116152","https://openalex.org/W4253234031","https://openalex.org/W4255986575"],"related_works":["https://openalex.org/W2074361791","https://openalex.org/W2916333875","https://openalex.org/W3183222058","https://openalex.org/W252734716","https://openalex.org/W3021144257","https://openalex.org/W4403872693","https://openalex.org/W3028144340","https://openalex.org/W4252869267","https://openalex.org/W1972016932","https://openalex.org/W252692730"],"abstract_inverted_index":{"The":[0],"three":[1],"major":[2],"methods":[3],"of":[4,24,44,65,83,88,92],"treatment":[5,76],"for":[6],"cancer":[7],"are":[8],"surgery,":[9],"irradiation,":[10],"and":[11,27,33,56,71],"chemotherapy.":[12],"Each":[13],"has":[14,29],"been":[15],"shown":[16],"to":[17,52],"have":[18],"considerable":[19],"efficacy":[20],"in":[21,47],"the":[22,41,63,79,98],"therapy":[23],"selected":[25],"cancers,":[26],"each":[28],"its":[30],"own":[31],"advantages":[32,55],"toxic":[34],"effects.":[35],"It":[36],"was":[37],"realized":[38],"early":[39],"that":[40],"combined":[42,75],"use":[43,64],"these":[45],"approaches":[46],"a":[48,84,93],"fashion":[49],"carefully":[50],"designed":[51],"optimize":[53],"their":[54],"interactions":[57],"might":[58],"produce":[59],"better":[60],"results":[61],"than":[62],"any":[66],"approach":[67],"alone.":[68],"Both":[69],"practical":[70],"theoretical":[72],"considerations":[73],"made":[74],"attractive.":[77],"When":[78],"complete":[80],"surgical":[81],"removal":[82],"tumor":[85],"involved":[86],"loss":[87],"an":[89],"extremity":[90],"or":[91],"nonvital":[94],"organ,":[95],"such":[96],"as":[97],"rectum":[99],".":[100,101,102]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
