{"id":"https://openalex.org/W2014871130","doi":"https://doi.org/10.1002/ijc.25492","title":"Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue","display_name":"Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue","publication_year":2010,"publication_date":"2010-06-02","ids":{"openalex":"https://openalex.org/W2014871130","doi":"https://doi.org/10.1002/ijc.25492","mag":"2014871130","pmid":"https://pubmed.ncbi.nlm.nih.gov/20521248"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.25492","doi":"https://doi.org/10.1002/ijc.25492","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.25492","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019514796","display_name":"Huaxiang Xu","orcid":"https://orcid.org/0000-0002-5346-2335","observed_orcids":["https://orcid.org/0000-0002-5346-2335"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua\u2010Xiang Xu","raw_affiliation_strings":["Fudan University, Shanghai, People's Republic of China","Hua-Xiang Xu and Xiao-Dong Zhu contributed equally to this work","Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Hua-Xiang Xu and Xiao-Dong Zhu contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101415393","display_name":"Xiao\u2010Dong Zhu","orcid":"https://orcid.org/0000-0001-9864-6763","observed_orcids":["https://orcid.org/0000-0001-9864-6763"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Dong Zhu","raw_affiliation_strings":["Hua-Xiang Xu and Xiao-Dong Zhu contributed equally to this work","Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hua-Xiang Xu and Xiao-Dong Zhu contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028929634","display_name":"Peng\u2013Yuan Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng\u2010Yuan Zhuang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014978008","display_name":"Jubo Zhang","orcid":"https://orcid.org/0000-0003-2954-9403","observed_orcids":["https://orcid.org/0000-0003-2954-9403"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju\u2010Bo Zhang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441588","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0002-2439-6076","observed_orcids":["https://orcid.org/0000-0002-2439-6076"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104033204","display_name":"Ling\u2013Qun Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling\u2010Qun Kong","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen\u2010Quan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen\u2010Quan Wang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462693","display_name":"Ying Jie Liang","orcid":"https://orcid.org/0000-0001-7824-5399","observed_orcids":["https://orcid.org/0000-0001-7824-5399","https://orcid.org/0009-0009-7337-1025"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074017253","display_name":"Wei\u2010Zhong Wu","orcid":"https://orcid.org/0000-0002-4936-7220","observed_orcids":["https://orcid.org/0000-0002-4936-7220"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei\u2010Zhong Wu","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364529","display_name":"Lu Wang","orcid":"https://orcid.org/0009-0001-0470-1694","observed_orcids":["https://orcid.org/0009-0001-0470-1694"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100659621","display_name":"Jia Fan","orcid":"https://orcid.org/0000-0001-5158-629X","observed_orcids":["https://orcid.org/0000-0001-5158-629X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Fan","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047500803","display_name":"Zhao\u2013You Tang","orcid":"https://orcid.org/0000-0002-9847-3150","observed_orcids":["https://orcid.org/0000-0002-9847-3150"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao\u2010You Tang","raw_affiliation_strings":["Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017352295","display_name":"Hui\u2010Chuan Sun","orcid":"https://orcid.org/0000-0003-3761-7058","observed_orcids":["https://orcid.org/0000-0003-3761-7058"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui\u2010Chuan Sun","raw_affiliation_strings":["","Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Fax: +86-21-64037181"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Fax: +86-21-64037181","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017352295"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":2.513,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.88888889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"128","issue":"7","first_page":"1559","last_page":"1569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.824999988079071},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.968999981880188},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.5239999890327454},{"id":"https://openalex.org/keywords/intrahepatic-metastasis","display_name":"intrahepatic metastasis","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8455530405044556},{"id":"https://openalex.org/C2776871010","wikidata":"https://www.wikidata.org/wiki/Q18030500","display_name":"Placental growth factor","level":4,"score":0.7875081300735474},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6587157845497131},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6257742643356323},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6116026639938354},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5212693214416504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4749867022037506},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4664824306964874},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.4464070498943329},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4399717450141907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41939854621887207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41729027032852173},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.3915942907333374},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.07240569591522217}],"mesh":[{"descriptor_ui":"D000072483","descriptor_name":"Placenta Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011257","descriptor_name":"Pregnancy Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.25492","doi":"https://doi.org/10.1002/ijc.25492","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.25492","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:20521248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20521248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1536690700","https://openalex.org/W1587020653","https://openalex.org/W1624769216","https://openalex.org/W1875554126","https://openalex.org/W1963876488","https://openalex.org/W1967600348","https://openalex.org/W1971837077","https://openalex.org/W1975547946","https://openalex.org/W1976081087","https://openalex.org/W1977999028","https://openalex.org/W1980814594","https://openalex.org/W1982068113","https://openalex.org/W1985585438","https://openalex.org/W1994193851","https://openalex.org/W1997773537","https://openalex.org/W1999758696","https://openalex.org/W2003801328","https://openalex.org/W2009671859","https://openalex.org/W2014148719","https://openalex.org/W2016569548","https://openalex.org/W2018786027","https://openalex.org/W2023854906","https://openalex.org/W2033413765","https://openalex.org/W2034319249","https://openalex.org/W2043817812","https://openalex.org/W2053026927","https://openalex.org/W2053526872","https://openalex.org/W2056202093","https://openalex.org/W2056207351","https://openalex.org/W2056574134","https://openalex.org/W2072554662","https://openalex.org/W2074004139","https://openalex.org/W2085547877","https://openalex.org/W2119281341","https://openalex.org/W2122656254","https://openalex.org/W2126128000","https://openalex.org/W2127248987","https://openalex.org/W2129712640","https://openalex.org/W2133650808","https://openalex.org/W2135113158","https://openalex.org/W2139877124","https://openalex.org/W2140088548","https://openalex.org/W2140632878","https://openalex.org/W2149271280","https://openalex.org/W2154576630","https://openalex.org/W2157535532","https://openalex.org/W2163382189","https://openalex.org/W2166573361","https://openalex.org/W2334576825","https://openalex.org/W3139763557","https://openalex.org/W4210973123","https://openalex.org/W4252851641"],"related_works":["https://openalex.org/W2020399388","https://openalex.org/W2358359619","https://openalex.org/W2033413765","https://openalex.org/W2334142027","https://openalex.org/W2382469323","https://openalex.org/W2792788630","https://openalex.org/W1970776952","https://openalex.org/W2619264956","https://openalex.org/W2083309365","https://openalex.org/W2117475784"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2,27,39],"factor-targeted":[3],"therapy":[4,29,241],"is":[5,17,30,47,223],"a":[6,165,206,237],"promising":[7],"treatment":[8],"for":[9,144],"hepatocellular":[10],"carcinoma":[11],"(HCC),":[12],"but":[13],"its":[14],"clinical":[15],"benefit":[16],"often":[18],"accompanied":[19],"by":[20,184],"acquired":[21],"resistance.":[22,34],"In":[23,50],"animal":[24],"studies,":[25],"antiplacental":[26],"factor":[28,40,143],"effective":[31],"with":[32,72,107,124,194,225],"less":[33],"The":[35,154],"role":[36],"of":[37,45,85,128,157,176,232,239],"placental":[38],"(PlGF)":[41],"in":[42,56,63,82,164,178,204,213],"the":[43,174],"progression":[44],"HCC":[46],"not":[48,105],"clear.":[49],"our":[51],"study,":[52],"we":[53],"used":[54],"immunohistochemistry":[55],"tissue":[57],"microarrays":[58],"to":[59,114],"investigate":[60],"PlGF":[61,77,89,96,102,119,159,177,190,200,221,234],"expression":[62,79,90,97,103,160,191,201,222],"tumor":[64,125,226],"and":[65,75,133,149,228,242],"peritumoral":[66,76,118,158,179,189,220],"liver":[67,180],"tissues":[68],"from":[69],"105":[70],"patients":[71],"HCC.":[73,233],"Intratumoral":[74,101],"mRNA":[78],"was":[80,91,104,122,139,161,192,202],"analyzed":[81],"another":[83],"cohort":[84,167],"37":[86],"patients.":[87],"Peritumoral":[88],"significantly":[92],"higher":[93],"than":[94],"intratumoral":[95],"(p":[98,146,151,197],"<":[99],"0.001).":[100],"associated":[106,123,193,224],"patients'":[108],"overall":[109],"survival":[110,229],"(OS)":[111],"or":[112],"time":[113],"recurrence":[115,227],"(TTR).":[116],"However,":[117],"expression,":[120],"which":[121],"size,":[126],"presence":[127],"intrahepatic":[129],"metastasis,":[130],"TNM":[131],"stage":[132],"Barcelona":[134],"Clinic":[135],"Liver":[136],"Cancer":[137],"stage,":[138],"an":[140],"independent":[141],"risk":[142],"OS":[145],"=":[147,152,169,198],"0.026)":[148],"TTR":[150],"0.041).":[153],"prognostic":[155],"value":[156],"further":[162,244],"validated":[163],"validation":[166],"(n":[168],"394).":[170],"We":[171,186],"inferred":[172],"that":[173,188,218],"elevation":[175],"might":[181],"be":[182,236],"induced":[183],"hypoxia.":[185],"found":[187],"hypoxia-inducible":[195],"factor-1\u03b1":[196],"0.017).":[199],"elevated":[203],"L02,":[205],"hepatic":[207],"cell":[208],"line,":[209],"under":[210],"hypoxic":[211],"conditions":[212],"vitro.":[214],"These":[215],"findings":[216],"indicate":[217],"high":[219],"after":[230],"resection":[231],"could":[235],"target":[238],"adjuvant":[240],"deserves":[243],"investigations.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}