{"id":"https://openalex.org/W2014848715","doi":"https://doi.org/10.1002/pros.1129","title":"Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity","display_name":"Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity","publication_year":2001,"publication_date":"2001-09-25","ids":{"openalex":"https://openalex.org/W2014848715","doi":"https://doi.org/10.1002/pros.1129","mag":"2014848715","pmid":"https://pubmed.ncbi.nlm.nih.gov/11582594"},"language":"en","primary_location":{"id":"doi:10.1002/pros.1129","doi":"https://doi.org/10.1002/pros.1129","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.1129","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067075162","display_name":"Avi Rimler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avi Rimler","raw_affiliation_strings":["Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007312106","display_name":"Zoran \u010culig","orcid":"https://orcid.org/0000-0002-5001-6153","observed_orcids":["https://orcid.org/0000-0002-5001-6153"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Zoran Culig","raw_affiliation_strings":["Department of Urology, Innsbruck University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Innsbruck University, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043979548","display_name":"Galit Levy\u2010Rimler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Galit Levy\u2010Rimler","raw_affiliation_strings":["Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109924804","display_name":"Zippora Lupowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Zippora Lupowitz","raw_affiliation_strings":["Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008951210","display_name":"Helmut Klocker","orcid":"https://orcid.org/0000-0001-7732-9443","observed_orcids":["https://orcid.org/0000-0001-7732-9443"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Helmut Klocker","raw_affiliation_strings":["Department of Urology, Innsbruck University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Innsbruck University, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051826396","display_name":"Haim Matzkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Haim Matzkin","raw_affiliation_strings":["Department of Urology Tel Aviv Medical Center and Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology Tel Aviv Medical Center and Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109191522","display_name":"Georg Hans Bartsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Georg Bartsch","raw_affiliation_strings":["Department of Urology, Innsbruck University, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Innsbruck University, Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113575407","display_name":"Nava Zisapel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Nava Zisapel","raw_affiliation_strings":["Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113575407"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":0.6032,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.6359333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"49","issue":"2","first_page":"145","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.09830000251531601,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":1.0},{"id":"https://openalex.org/keywords/nuclear-exclusion","display_name":"nuclear exclusion","score":0.9629999995231628},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8479999899864197},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9710000157356262},{"id":"https://openalex.org/keywords/androgen-response-element","display_name":"androgen response element","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.7900000214576721},{"id":"https://openalex.org/keywords/receptor-agonist-binding","display_name":"receptor agonist binding","score":0.6489999890327454},{"id":"https://openalex.org/keywords/transcriptional-activity","display_name":"transcriptional activity","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.865962028503418},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8217939138412476},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8016831874847412},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7195156812667847},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6697127819061279},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6204022169113159},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5821067094802856},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.5630016326904297},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5404840707778931},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47310495376586914},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42633187770843506},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.4161931276321411},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3658745586872101},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34266048669815063},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.31207042932510376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20674404501914978},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20164984464645386}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009277","descriptor_name":"Nandrolone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009277","descriptor_name":"Nandrolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059002","descriptor_name":"Androgen Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/pros.1129","doi":"https://doi.org/10.1002/pros.1129","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.1129","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:11582594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11582594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W71653146","https://openalex.org/W173545474","https://openalex.org/W1484666375","https://openalex.org/W1596063300","https://openalex.org/W1970841622","https://openalex.org/W1984607545","https://openalex.org/W1987609643","https://openalex.org/W2027515382","https://openalex.org/W2031423487","https://openalex.org/W2032593619","https://openalex.org/W2033269603","https://openalex.org/W2046570771","https://openalex.org/W2072865274","https://openalex.org/W2079895325","https://openalex.org/W2091291770","https://openalex.org/W2095873383","https://openalex.org/W2106107148","https://openalex.org/W2106494062","https://openalex.org/W2134812217","https://openalex.org/W2135897093","https://openalex.org/W2136350449","https://openalex.org/W2150882718","https://openalex.org/W2152898692","https://openalex.org/W2161787364","https://openalex.org/W2468722314","https://openalex.org/W4256482144","https://openalex.org/W4301507766"],"related_works":["https://openalex.org/W2069061930","https://openalex.org/W2465500955","https://openalex.org/W2266588603","https://openalex.org/W2024028595","https://openalex.org/W2009353546","https://openalex.org/W2108944092","https://openalex.org/W2161919679","https://openalex.org/W2009064703","https://openalex.org/W2004158383","https://openalex.org/W7097746319"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,16,29,40,116],"androgen":[2,10,22],"receptor":[3],"(AR)":[4],"promotes":[5],"growth":[6],"and":[7,13,26,49,57,77,84,96,104,151],"functionality":[8],"of":[9,31,42,79,86,98,111,120,127,140,144],"sensitive":[11],"benign":[12],"cancer":[14,64,133],"tissues.":[15],"pineal":[17],"hormone":[18],"melatonin":[19,32,43],"is":[20,136],"an":[21],"protagonist":[23],"in":[24,27,33,62,74,130,147],"vivo":[25],"vitro.":[28],"interference":[30],"the":[34,75,91,121,125,131,137,145],"AR":[35,45,72,87,112,122,128,146,159],"cascade":[36],"was":[37],"explored.":[38],"METHODS:":[39],"effects":[41],"on":[44],"expression,":[46],"level,":[47],"agonist":[48,88],"androgen-response":[50],"element":[51],"(ARE)":[52],"binding,":[53],"reporter":[54,93],"gene":[55,94],"activity":[56,95,129],"intracellular":[58],"localization":[59],"were":[60,100],"explored":[61],"prostate":[63,132,148],"LNCaP":[65],"cell":[66],"line.":[67],"RESULTS:":[68],"Melatonin":[69],"increased":[70],"immunoreactive":[71],"cells":[73,150],"absence":[76],"presence":[78],"dihydrotestosterone.":[80],"Despite":[81],"this":[82],"increase":[83],"maintenance":[85],"binding":[89],"capacity,":[90],"androgen-induced":[92],"suppression":[97],"AR-mRNA":[99],"attenuated.":[101],"Immunocytochemical":[102],"analysis":[103],"subcellular":[105],"fractionation":[106],"studies":[107],"revealed":[108],"nuclear":[109,118],"exclusion":[110,119],"by":[113],"melatonin.":[114],"CONCLUSIONS:":[115],"melatonin-mediated":[117],"may":[123,152],"explain":[124],"attenuation":[126],"cells.":[134],"This":[135],"first":[138],"demonstration":[139],"a":[141,154],"hormone-induced":[142],"mislocalization":[143],"epithelial":[149],"represent":[153],"novel":[155],"route":[156],"for":[157],"regulating":[158],"activity.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}