{"id":"https://openalex.org/W2014846342","doi":"https://doi.org/10.1002/cncr.23255","title":"Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance","display_name":"Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance","publication_year":2008,"publication_date":"2008-01-10","ids":{"openalex":"https://openalex.org/W2014846342","doi":"https://doi.org/10.1002/cncr.23255","mag":"2014846342","pmid":"https://pubmed.ncbi.nlm.nih.gov/18186493"},"language":"en","primary_location":{"id":"doi:10.1002/cncr.23255","doi":"https://doi.org/10.1002/cncr.23255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23255","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23255","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23255","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039573127","display_name":"Lisa D. Duncan","orcid":"https://orcid.org/0000-0003-3319-1133","observed_orcids":["https://orcid.org/0000-0003-3319-1133"]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lisa Duncan","raw_affiliation_strings":["Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee 37920, USA. ldduncan@utmck.edu","Department of Pathology University of Tennessee Medical Center Knoxville Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee 37920, USA. ldduncan@utmck.edu","institution_ids":["https://openalex.org/I2802076678"]},{"raw_affiliation_string":"Department of Pathology University of Tennessee Medical Center Knoxville Tennessee","institution_ids":["https://openalex.org/I2802076678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020438528","display_name":"Sanjivini V. Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjivini Jacob","raw_affiliation_strings":["Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee","institution_ids":["https://openalex.org/I2802076678"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011648538","display_name":"Elizabeth W. Hubbard","orcid":"https://orcid.org/0000-0002-2358-5190","observed_orcids":["https://orcid.org/0000-0002-2358-5190"]},"institutions":[{"id":"https://openalex.org/I2802076678","display_name":"University of Tennessee Medical Center","ror":"https://ror.org/0277n1841","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802076678"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Hubbard","raw_affiliation_strings":["Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Tennessee Medical Center, Knoxville, Tennessee","institution_ids":["https://openalex.org/I2802076678"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039573127"],"corresponding_institution_ids":["https://openalex.org/I2802076678"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":3.3242,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.91120424,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"114","issue":"1","first_page":"34","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13544","display_name":"Women's cancer prevention and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ascus","display_name":"ASCUS","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cervical-cancer-screening","display_name":"cervical cancer screening","score":0.5920000076293945},{"id":"https://openalex.org/keywords/high-risk-hpv","display_name":"high-risk HPV","score":0.9089999794960022},{"id":"https://openalex.org/keywords/high-grade-squamous-intraepithelial-lesion","display_name":"high-grade squamous intraepithelial lesion","score":0.902999997138977},{"id":"https://openalex.org/keywords/p16-immunohistochemistry","display_name":"p16 immunohistochemistry","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hybrid-capture-2","display_name":"Hybrid Capture 2","score":0.953000009059906},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.88799649477005},{"id":"https://openalex.org/C2777120189","wikidata":"https://www.wikidata.org/wiki/Q780067","display_name":"Triage","level":2,"score":0.7856850624084473},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42980116605758667},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.1885519027709961}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014626","descriptor_name":"Vaginal Smears","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D065006","descriptor_name":"Papanicolaou Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/cncr.23255","doi":"https://doi.org/10.1002/cncr.23255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23255","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23255","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:18186493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18186493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1002/cncr.23255","doi":"https://doi.org/10.1002/cncr.23255","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cncr.23255","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cncr.23255","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014846342.pdf","grobid_xml":"https://content.openalex.org/works/W2014846342.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W190015672","https://openalex.org/W1486515846","https://openalex.org/W1722478811","https://openalex.org/W1831319429","https://openalex.org/W1906037527","https://openalex.org/W1921212788","https://openalex.org/W1965662235","https://openalex.org/W1966159053","https://openalex.org/W1976051908","https://openalex.org/W1977636641","https://openalex.org/W1982395149","https://openalex.org/W1983231924","https://openalex.org/W1983348452","https://openalex.org/W1983545938","https://openalex.org/W1987350137","https://openalex.org/W1992513534","https://openalex.org/W1997073961","https://openalex.org/W1997802208","https://openalex.org/W1998218812","https://openalex.org/W1999876280","https://openalex.org/W2006802155","https://openalex.org/W2008106081","https://openalex.org/W2009469731","https://openalex.org/W2010035888","https://openalex.org/W2020171800","https://openalex.org/W2020267628","https://openalex.org/W2022358833","https://openalex.org/W2022542106","https://openalex.org/W2028750854","https://openalex.org/W2035348064","https://openalex.org/W2037082184","https://openalex.org/W2038500217","https://openalex.org/W2044434763","https://openalex.org/W2060786724","https://openalex.org/W2064423429","https://openalex.org/W2066848701","https://openalex.org/W2066980099","https://openalex.org/W2070070984","https://openalex.org/W2071053051","https://openalex.org/W2073439462","https://openalex.org/W2073691035","https://openalex.org/W2076409816","https://openalex.org/W2084557738","https://openalex.org/W2094581205","https://openalex.org/W2117775808","https://openalex.org/W2121189112","https://openalex.org/W2133765716","https://openalex.org/W2135253681","https://openalex.org/W2141196337","https://openalex.org/W2142579389","https://openalex.org/W2152432521","https://openalex.org/W2165685143","https://openalex.org/W2170939558","https://openalex.org/W2332665748","https://openalex.org/W2418513099","https://openalex.org/W4235925468","https://openalex.org/W6681154495"],"related_works":["https://openalex.org/W2141999158","https://openalex.org/W2070070984","https://openalex.org/W2100242086","https://openalex.org/W342327467","https://openalex.org/W2118049614","https://openalex.org/W2044434763","https://openalex.org/W2012016836","https://openalex.org/W2383121241","https://openalex.org/W2000012702","https://openalex.org/W2011701557"],"abstract_inverted_index":{"BACKGROUND:":[0],"P16(INK4a)":[1],"(p16)":[2],"has":[3,257],"emerged":[4],"as":[5,56,83,116,221,293],"a":[6,24,57,222,294],"biomarker":[7],"for":[8,85,234],"the":[9,38,201,206,237],"detection":[10],"of":[11,37,44,65,170,200,243,265,280],"high-risk":[12],"human":[13],"papillomavirus":[14],"(HR-HPV)":[15],"in":[16,133,198,274],"Papanicolaou":[17],"(Pap)":[18],"smears.":[19,70,300],"Many":[20],"studies":[21],"have":[22],"confirmed":[23],"strong":[25],"correlation":[26,259],"between":[27,126],"p16":[28,41,52,78,102,121,145,171,207,244,256,269,289],"immunohistochemical":[29],"positivity":[30],"and":[31,46,98,130,158,162,168,177,227,239],"high-grade":[32],"squamous":[33,63],"intraepithelial":[34,86],"lesions":[35],"(HSIL)":[36],"cervix.":[39],"Because":[40],"is":[42],"predictive":[43,241],"HR-HPV":[45],"HSIL,":[47],"it":[48],"seems":[49],"plausible":[50],"that":[51,205,255,288],"could":[53,80],"be":[54,81,211,291],"used":[55,212,292],"diagnostic":[58],"tool":[59],"to":[60,213,219,224,296],"triage":[61,297],"atypical":[62,298],"cells":[64,134],"undetermined":[66],"significance":[67,194],"(ASCUS)":[68],"Pap":[69,74,112,215,276],"In":[71,267],"this":[72],"way,":[73],"smears":[75,113,216,285],"with":[76,135,149,174,183,260],"no":[77],"staining":[79,270],"recategorized":[82],"negative":[84],"lesion":[87],"or":[88,141],"malignancy":[89],"(NILM)":[90],"before":[91],"final":[92],"case":[93],"disposition,":[94],"thus":[95],"preventing":[96],"unnecessary":[97,226],"costly":[99],"follow-up.":[100,229],"METHODS:":[101],"immunostains":[103],"were":[104,123,179,250],"performed":[105],"on":[106],"178":[107],"ThinPrep":[108],"(Cytyc,":[109],"Marlborough,":[110],"Mass)":[111],"signed":[114],"out":[115],"ASCUS":[117,218],"among":[118],"5":[119],"cytopathologists.":[120],"stains":[122],"independently":[124],"scored":[125],"0":[127],"(no":[128],"staining)":[129],"4":[131],"(staining":[132],"nuclear":[136],"aberration)":[137],"by":[138],"either":[139],"2":[140,153],"3":[142],"pathologists.":[143],"The":[144,166],"score":[146,208],"was":[147,195,271],"compared":[148,173],"both":[150,175,184],"Hybrid":[151],"Capture":[152],"(hc(2))":[154],"(Digene,":[155],"Gaithersburg,":[156],"Md)":[157],"follow-up":[159,178,248,262],"(Pap":[160],"smear":[161],"tissue)":[163],"results.":[164],"RESULTS:":[165],"sensitivity":[167,238],"specificity":[169],"immunohistochemistry":[172],"hc(2)":[176],"not":[180,196,231],"statistically":[181,252],"significant,":[182],"data":[185,202],"subsets":[186],"having":[187],"P-values":[188],"greater":[189],"than":[190,263],".05.":[191],"CONCLUSIONS:":[192],"Statistical":[193],"demonstrated":[197],"any":[199],"subsets,":[203],"indicating":[204,287],"alone":[209],"cannot":[210,290],"recategorize":[214],"from":[217],"NILM":[220,283],"means":[223],"prevent":[225],"expensive":[228],"Although":[230],"meeting":[232],"criteria":[233],"statistical":[235],"significance,":[236],"positive":[240],"value":[242],"scores":[245],"versus":[246],"tissue":[247,261],"only":[249],"more":[251],"favorable,":[253],"suggesting":[254],"better":[258],"results":[264],"hc(2).":[266],"addition,":[268],"identified":[272],"consistently":[273],"atrophic":[275,284,299],"smears,":[277],"including":[278],"23":[279],"25":[281],"additional":[282],"stained,":[286],"marker":[295]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}