{"id":"https://openalex.org/W2014837338","doi":"https://doi.org/10.1371/journal.pone.0055147","title":"Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma","display_name":"Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma","publication_year":2013,"publication_date":"2013-01-30","ids":{"openalex":"https://openalex.org/W2014837338","doi":"https://doi.org/10.1371/journal.pone.0055147","mag":"2014837338","pmid":"https://pubmed.ncbi.nlm.nih.gov/23383087","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3559337"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0055147","doi":"https://doi.org/10.1371/journal.pone.0055147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0055147","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055147&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055147&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078851784","display_name":"Nobuyuki Kurosawa","orcid":"https://orcid.org/0000-0002-1548-4541","observed_orcids":["https://orcid.org/0000-0002-1548-4541"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Kurosawa","raw_affiliation_strings":["Faculty of Science and Engineering, Graduate School, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Graduate School, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015064264","display_name":"Rika Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rika Fujimoto","raw_affiliation_strings":["Department of Immunology, Kochi Medical School, Kochi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Kochi Medical School, Kochi, Japan","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077736337","display_name":"Tatsuhiko Ozawa","orcid":"https://orcid.org/0000-0002-3112-452X","observed_orcids":["https://orcid.org/0000-0002-3112-452X"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiko Ozawa","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043281173","display_name":"Takahiro Itoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125681","display_name":"Imamura Hospital","ror":"https://ror.org/02xt2gf57","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210125681"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Itoyama","raw_affiliation_strings":["Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan","institution_ids":["https://openalex.org/I4210125681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006381826","display_name":"Naoki Sadamori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132400726","display_name":"University of Nagasaki","ror":"https://ror.org/03ppx1p25","country_code":"JP","type":"education","lineage":["https://openalex.org/I132400726"]},{"id":"https://openalex.org/I43777268","display_name":"Nagasaki University","ror":"https://ror.org/058h74p94","country_code":"JP","type":"education","lineage":["https://openalex.org/I43777268"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Sadamori","raw_affiliation_strings":["Department of Nursing, Faculty of Nursing and Nutrition, University of Nagasaki, Nagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Faculty of Nursing and Nutrition, University of Nagasaki, Nagasaki, Japan","institution_ids":["https://openalex.org/I132400726","https://openalex.org/I43777268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019149598","display_name":"Masaharu Isobe","orcid":"https://orcid.org/0000-0003-1864-9273","observed_orcids":["https://orcid.org/0000-0003-1864-9273"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaharu Isobe","raw_affiliation_strings":["Faculty of Science and Engineering, Graduate School, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Engineering, Graduate School, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5019149598"],"corresponding_institution_ids":["https://openalex.org/I42766147"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.2932,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77787566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"e55147","last_page":"e55147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-t-cell-leukemia-lymphoma","display_name":"adult T-cell leukemia/lymphoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bcl11b","display_name":"BCL11B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.8100000023841858},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chromosome-breakpoints","display_name":"chromosomal breakpoints","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ectopic-expression","display_name":"ectopic expression","score":0.7609999775886536},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.675000011920929},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.7105534076690674},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6761372685432434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6203545928001404},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5970658659934998},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.5036696791648865},{"id":"https://openalex.org/C2780815077","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Adult T-cell leukemia/lymphoma","level":4,"score":0.4938405156135559},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.48607137799263},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.472308874130249},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.41232794523239136},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.3830973207950592},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35279756784439087},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35113221406936646},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34827470779418945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2705671787261963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2520166039466858},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2314162254333496},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12532731890678406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08372488617897034}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015459","descriptor_name":"Leukemia-Lymphoma, Adult T-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056905","descriptor_name":"Chromosome Breakpoints","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0055147","doi":"https://doi.org/10.1371/journal.pone.0055147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0055147","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055147&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2564404","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3559337","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23383087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23383087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3559337","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3559337/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.809.5572","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.809.5572","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/50/20/pone.0055147.PMC3559337.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c07d257f8649478e8fcde50c2e88eeab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c07d257f8649478e8fcde50c2e88eeab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 1, p e55147 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/154933","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Reduced_Level_of_the_BCL11B_Protein_Is_Associated_with_Adult_T_Cell_Leukemia_Lymphoma__/154933","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0055147","doi":"https://doi.org/10.1371/journal.pone.0055147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0055147","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0055147&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G41470970","display_name":"Development and analysis of human monoclonal antibodies derived from patients with cancer","funder_award_id":"23650607","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5858680773","display_name":"Development of methods for isolation of human monoclonal antibodies recognizing cancer stem cells","funder_award_id":"25640075","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5903466393","display_name":"Development of rapid generation of antibodies with high affinity for improvement of detection limi","funder_award_id":"23790617","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014837338.pdf","grobid_xml":"https://content.openalex.org/works/W2014837338.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1545515720","https://openalex.org/W1556609966","https://openalex.org/W1835972708","https://openalex.org/W1969580799","https://openalex.org/W1973632024","https://openalex.org/W1979596837","https://openalex.org/W1980952225","https://openalex.org/W1987891300","https://openalex.org/W1990125381","https://openalex.org/W1999480352","https://openalex.org/W1999706014","https://openalex.org/W2003913372","https://openalex.org/W2005308066","https://openalex.org/W2008033547","https://openalex.org/W2010957709","https://openalex.org/W2012327438","https://openalex.org/W2012873230","https://openalex.org/W2037385179","https://openalex.org/W2041785673","https://openalex.org/W2045016873","https://openalex.org/W2047241508","https://openalex.org/W2059040596","https://openalex.org/W2060527795","https://openalex.org/W2062402161","https://openalex.org/W2063138816","https://openalex.org/W2068364663","https://openalex.org/W2071592765","https://openalex.org/W2079440799","https://openalex.org/W2079973634","https://openalex.org/W2080618316","https://openalex.org/W2089225780","https://openalex.org/W2094831592","https://openalex.org/W2094985098","https://openalex.org/W2105186755","https://openalex.org/W2116913871","https://openalex.org/W2118643966","https://openalex.org/W2155926744","https://openalex.org/W2158532144","https://openalex.org/W2168656234","https://openalex.org/W2410638161"],"related_works":["https://openalex.org/W4223489233","https://openalex.org/W2724554474","https://openalex.org/W7146268628","https://openalex.org/W2037006866","https://openalex.org/W2557223231","https://openalex.org/W2080618316","https://openalex.org/W2114107166","https://openalex.org/W2560928168","https://openalex.org/W2003913372","https://openalex.org/W2524494395"],"abstract_inverted_index":{"BACKGROUND:":[0],"Adult":[1],"T-cell":[2,12,89,125],"leukemia/lymphoma":[3],"(ATLL)":[4],"develops":[5],"in":[6,48,64,73,88,123,133,137,143,159,170],"a":[7,77,85,157,167],"small":[8],"proportion":[9],"of":[10,40,57,62,76,116,130,162,174],"human":[11],"leukemia":[13],"virus":[14],"type":[15],"I":[16],"(HTLV-I)-infected":[17],"individuals.":[18],"However,":[19],"the":[20,37,45,69,74,92,117,153,160,163,171],"mechanism":[21],"by":[22,99],"which":[23,83],"HTLV-I":[24],"causes":[25],"ATLL":[26,50,66,94,175],"has":[27],"not":[28,142],"been":[29],"fully":[30],"elucidated.":[31],"To":[32],"provide":[33,152],"fundamental":[34],"insights":[35],"into":[36],"multistep":[38,172],"process":[39],"leukemogenesis,":[41],"we":[42,97],"have":[43],"mapped":[44],"chromosomal":[46],"abnormalities":[47],"50":[49],"cases":[51,95],"to":[52],"identify":[53],"potential":[54],"key":[55,168],"regulators":[56],"ATLL.":[58],"RESULTS:":[59],"The":[60,127],"analysis":[61],"breakpoints":[63],"one":[65,106],"case":[67],"with":[68],"translocations":[70],"t(14;17)(q32;q22-23)":[71],"resulted":[72,132],"identification":[75],"Kruppel":[78],"zinc":[79],"finger":[80],"gene,":[81],"BCL11B,":[82],"plays":[84],"crucial":[86],"role":[87],"development.":[90],"Among":[91],"7":[93],"that":[96,156],"examined":[98],"immunofluorescence":[100],"analysis,":[101],"4":[102],"displayed":[103,107],"low":[104],"and":[105,149],"moderate":[108],"BCL11B":[109,118,131,164],"signal":[110],"intensities.":[111],"A":[112],"dramatically":[113],"reduced":[114],"level":[115,161],"protein":[119,165],"was":[120],"also":[121],"found":[122],"HTLV-I-positive":[124],"lines.":[126],"ectopic":[128],"expression":[129],"significant":[134],"growth":[135],"suppression":[136],"ATLL-derived":[138],"cell":[139],"lines":[140],"but":[141],"Jurkat":[144],"cells.":[145],"CONCLUSIONS:":[146],"Our":[147],"genetic":[148],"functional":[150],"data":[151],"first":[154],"evidence":[155],"reduction":[158],"is":[166],"event":[169],"progression":[173],"leukemogenesis.":[176]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}