{"id":"https://openalex.org/W2014834568","doi":"https://doi.org/10.1007/s11882-001-0025-3","title":"Gene therapy for immunodeficiency","display_name":"Gene therapy for immunodeficiency","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W2014834568","doi":"https://doi.org/10.1007/s11882-001-0025-3","mag":"2014834568","pmid":"https://pubmed.ncbi.nlm.nih.gov/11892066"},"language":"en","primary_location":{"id":"doi:10.1007/s11882-001-0025-3","doi":"https://doi.org/10.1007/s11882-001-0025-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11882-001-0025-3","pdf_url":null,"source":{"id":"https://openalex.org/S10734860","display_name":"Current Allergy and Asthma Reports","issn_l":"1529-7322","issn":["1529-7322","1534-6315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Allergy and Asthma Reports","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062385004","display_name":"Fabio Candotti","orcid":"https://orcid.org/0000-0001-6399-6042","observed_orcids":["https://orcid.org/0000-0001-6399-6042"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fabio Candotti","raw_affiliation_strings":["Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10C103, Bethesda, MD 20892-1851, USA. fabio@nhgri.nih.gov","Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10C103, Bethesda, MD 20892-1851, USA. fabio@nhgri.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062385004"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.0365,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.05320435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"5","first_page":"407","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.972000002861023},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.9819999933242798},{"id":"https://openalex.org/keywords/adenosine-deaminase-deficiency","display_name":"adenosine deaminase deficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-granulomatous-disease","display_name":"chronic granulomatous disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/x-linked-severe-combined-immunodeficiency","display_name":"X-linked severe combined immunodeficiency","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-correction","display_name":"gene correction","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2781161190","wikidata":"https://www.wikidata.org/wiki/Q1055374","display_name":"Adenosine deaminase deficiency","level":4,"score":0.8802107572555542},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.854192852973938},{"id":"https://openalex.org/C2779468541","wikidata":"https://www.wikidata.org/wiki/Q1334408","display_name":"Severe combined immunodeficiency","level":3,"score":0.7979589700698853},{"id":"https://openalex.org/C2778175462","wikidata":"https://www.wikidata.org/wiki/Q2165663","display_name":"Chronic granulomatous disease","level":2,"score":0.6583280563354492},{"id":"https://openalex.org/C2779019163","wikidata":"https://www.wikidata.org/wiki/Q3043160","display_name":"Primary immunodeficiency","level":3,"score":0.5948611497879028},{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.5803337097167969},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.5651972889900208},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.5530213713645935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5076612234115601},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4896278977394104},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4341508448123932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42921721935272217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4043227732181549},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30546846985816956},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2599503993988037},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.21936902403831482},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20640328526496887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14155712723731995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1411442756652832},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.13786581158638},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.12234264612197876}],"mesh":[{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D000243","descriptor_name":"Adenosine Deaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11882-001-0025-3","doi":"https://doi.org/10.1007/s11882-001-0025-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11882-001-0025-3","pdf_url":null,"source":{"id":"https://openalex.org/S10734860","display_name":"Current Allergy and Asthma Reports","issn_l":"1529-7322","issn":["1529-7322","1534-6315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Allergy and Asthma Reports","raw_type":"journal-article"},{"id":"pmid:11892066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11892066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current allergy and asthma reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W13849965","https://openalex.org/W16642357","https://openalex.org/W59046331","https://openalex.org/W79518043","https://openalex.org/W91890250","https://openalex.org/W100221550","https://openalex.org/W110839551","https://openalex.org/W132845342","https://openalex.org/W163577050","https://openalex.org/W175604019","https://openalex.org/W193981811","https://openalex.org/W206621073","https://openalex.org/W257878791","https://openalex.org/W1495681576","https://openalex.org/W1536258411","https://openalex.org/W1668659972","https://openalex.org/W1756978269","https://openalex.org/W1978341830","https://openalex.org/W1981799120","https://openalex.org/W1987643438","https://openalex.org/W1988614032","https://openalex.org/W1996984326","https://openalex.org/W2024292299","https://openalex.org/W2029255163","https://openalex.org/W2032678451","https://openalex.org/W2038705787","https://openalex.org/W2045957511","https://openalex.org/W2066271426","https://openalex.org/W2075869284","https://openalex.org/W2078458905","https://openalex.org/W2093804554","https://openalex.org/W2095081325","https://openalex.org/W2096773218","https://openalex.org/W2119648704","https://openalex.org/W2127433915","https://openalex.org/W2129321368","https://openalex.org/W2136706405","https://openalex.org/W2143729842","https://openalex.org/W2151351188","https://openalex.org/W2170272569","https://openalex.org/W2171030311","https://openalex.org/W2189180831","https://openalex.org/W2263174759","https://openalex.org/W2273926125","https://openalex.org/W2280192492","https://openalex.org/W2289043455","https://openalex.org/W2290402170","https://openalex.org/W2314539898","https://openalex.org/W2318932960","https://openalex.org/W2322366489","https://openalex.org/W2323132531","https://openalex.org/W2330288813","https://openalex.org/W2335254805","https://openalex.org/W2336924892","https://openalex.org/W2342791518","https://openalex.org/W2395212933","https://openalex.org/W2417884920","https://openalex.org/W2502042151","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2325350956","https://openalex.org/W2462748515","https://openalex.org/W2912603519","https://openalex.org/W1977174214","https://openalex.org/W2091787491","https://openalex.org/W1987348621","https://openalex.org/W2119873354","https://openalex.org/W1989639266","https://openalex.org/W2313717716","https://openalex.org/W4241005697"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
