{"id":"https://openalex.org/W2014834068","doi":"https://doi.org/10.1097/00000542-199612000-00024","title":"Effects of Pre- and Postischemic Administration of Thiopental on Transmitter Amino Acid Release and Histologic Outcome in Gerbils","display_name":"Effects of Pre- and Postischemic Administration of Thiopental on Transmitter Amino Acid Release and Histologic Outcome in Gerbils","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2014834068","doi":"https://doi.org/10.1097/00000542-199612000-00024","mag":"2014834068","pmid":"https://pubmed.ncbi.nlm.nih.gov/8968190"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-199612000-00024","doi":"https://doi.org/10.1097/00000542-199612000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199612000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/85/6/1422/365112/0000542-199612000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/85/6/1422/365112/0000542-199612000-00024.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065894642","display_name":"Kazuhiko Amakawa","orcid":"https://orcid.org/0000-0003-1012-4368","observed_orcids":["https://orcid.org/0000-0003-1012-4368"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Amakawa","raw_affiliation_strings":["Department of Anesthesiology and Resuscitology, Ehime University, School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Resuscitology, Ehime University, School of Medicine, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069240767","display_name":"Naoto Adachi","orcid":"https://orcid.org/0000-0001-8376-4900","observed_orcids":["https://orcid.org/0000-0001-8376-4900","https://orcid.org/0000-0002-7746-6824"]},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Adachi","raw_affiliation_strings":["Lecturer","Ehime University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lecturer","institution_ids":[]},{"raw_affiliation_string":"Ehime University","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046786082","display_name":"Keyue Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keyue Liu","raw_affiliation_strings":["Visiting Researcher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Visiting Researcher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071812892","display_name":"Keizo Ikemune","orcid":"https://orcid.org/0000-0002-2151-3716","observed_orcids":["https://orcid.org/0000-0002-2151-3716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keizo Ikemune","raw_affiliation_strings":["Researcher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Researcher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002193336","display_name":"Taro Fujitani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taro Fujitani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082340","display_name":"Tatsuru Arai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuru Arai","raw_affiliation_strings":["Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2395,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.77336277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"85","issue":"6","first_page":"1422","last_page":"1430."},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.33250001072883606,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.33250001072883606,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.28130000829696655,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.08889999985694885,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thiopental","display_name":"thiopental","score":1.0},{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/excitatory-amino-acid-release","display_name":"excitatory amino acid release","score":0.7599999904632568},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8090000152587891},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glycine","display_name":"glycine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.8429999947547913},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.8560000061988831},{"id":"https://openalex.org/keywords/delayed-neuronal-death","display_name":"delayed neuronal death","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anoxic-depolarization","display_name":"anoxic depolarization","score":0.9779999852180481},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7950000166893005},{"id":"https://openalex.org/keywords/reperfusion","display_name":"reperfusion","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gerbils","display_name":"gerbils","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2776932660","wikidata":"https://www.wikidata.org/wiki/Q32921","display_name":"Halothane","level":2,"score":0.7783541679382324},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.763943076133728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7398251891136169},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.6885115504264832},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6481132507324219},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.6260359883308411},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5734453797340393},{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.5601995587348938},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5386947989463806},{"id":"https://openalex.org/C2778349805","wikidata":"https://www.wikidata.org/wiki/Q906102","display_name":"Thiamylal","level":2,"score":0.5327582359313965},{"id":"https://openalex.org/C2910962159","wikidata":"https://www.wikidata.org/wiki/Q410179","display_name":"Thiopental Sodium","level":3,"score":0.49471279978752136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4738388657569885},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4432337284088135},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.42839616537094116},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34082043170928955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3246137499809265},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.19560307264328003},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1803554892539978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15675276517868042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14635533094406128},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.13332638144493103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13250449299812317},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002546","descriptor_name":"Ischemic Attack, Transient","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013874","descriptor_name":"Thiopental","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013874","descriptor_name":"Thiopental","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018846","descriptor_name":"Excitatory Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-199612000-00024","doi":"https://doi.org/10.1097/00000542-199612000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199612000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/85/6/1422/365112/0000542-199612000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:8968190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8968190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1097/00000542-199612000-00024","doi":"https://doi.org/10.1097/00000542-199612000-00024","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-199612000-00024","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/85/6/1422/365112/0000542-199612000-00024.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9483000040054321,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014834068.pdf","grobid_xml":"https://content.openalex.org/works/W2014834068.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1602154871","https://openalex.org/W1967568884","https://openalex.org/W1971354326","https://openalex.org/W1986622316","https://openalex.org/W1993578598","https://openalex.org/W1997554491","https://openalex.org/W2000216283","https://openalex.org/W2002090821","https://openalex.org/W2017583591","https://openalex.org/W2023334070","https://openalex.org/W2024312254","https://openalex.org/W2043028931","https://openalex.org/W2049027659","https://openalex.org/W2056734745","https://openalex.org/W2063537428","https://openalex.org/W2075836553","https://openalex.org/W2076674238","https://openalex.org/W2079344865","https://openalex.org/W2080136902","https://openalex.org/W2104532925","https://openalex.org/W2104592058","https://openalex.org/W2112763282","https://openalex.org/W2169129605","https://openalex.org/W2470917600","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2394759733","https://openalex.org/W2074870118","https://openalex.org/W1983383794","https://openalex.org/W2023334070","https://openalex.org/W2412798843","https://openalex.org/W7099216295","https://openalex.org/W1979567083","https://openalex.org/W2495491241","https://openalex.org/W1968553874","https://openalex.org/W1994524492"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,58,92,135,245,293],"mechanism":[2],"by":[3,73,84,147],"which":[4,33],"barbiturates":[5],"protect":[6,273],"neurons":[7],"against":[8],"ischemia":[9,18,69,86,132,149,206,284],"is":[10],"unclear,":[11],"particularly":[12],"when":[13],"they":[14],"are":[15],"given":[16,126,159],"after":[17,68,128,218,249,283],"or":[19,67],"reperfusion":[20],"begins.":[21],"Because":[22],"an":[23],"excess":[24],"release":[25,309],"of":[26,41,60,63,97,131,164,184,221,247,262,295,304],"excitatory":[27,306],"neurotransmitters":[28],"causes":[29],"postsynaptic":[30],"membrane":[31],"depolarization,":[32],"triggers":[34],"neuronal":[35,76,174],"damage":[36],"in":[37,53,78,90,95,138,142,152,210,223],"ischemia,":[38,277],"the":[39,114,139,143,170,193,202,219,224,236,260,274,302,305,311],"effects":[40,59],"thiopental":[42,64,127,165,228,248],"on":[43],"histologic":[44],"outcome,":[45],"ischemia-induced":[46,93],"amino":[47,212,307],"acid":[48,104,308],"release,":[49],"and":[50,102,113,123,157,265,310],"anoxic":[51,263],"depolarization":[52,264],"gerbils":[54],"were":[55,70,105,133,150],"studied.":[56],"METHODS:":[57],"different":[61],"doses":[62,168],"administered":[65],"before":[66,291],"examined":[71],"morphologically":[72],"assessing":[74],"delayed":[75,173],"death":[77,175],"hippocampal":[79,144],"CA1":[80,145],"pyramidal":[81],"cells":[82],"produced":[83,207],"forebrain":[85,148],"for":[87,172,187,196,240],"3":[88,214],"min":[89,189,198,217],"gerbils.":[91],"changes":[94,136],"output":[96],"aspartate,":[98],"glutamate,":[99],"glycine,":[100],"taurine,":[101],"gamma-aminobutyric":[103],"measured":[106],"using":[107],"a":[108,117,120,124,129,182,286],"microdialysis-high-performance":[109],"liquid":[110],"chromatography":[111],"procedure,":[112],"differences":[115],"among":[116],"halothane-anesthetized":[118,225],"group,":[119,122],"thiopental-administered":[121],"group":[125],"period":[130],"evaluated.":[134],"induced":[137],"direct-current":[140,312],"potential":[141,313],"area":[146],"compared":[151],"animals":[153],"anesthetized":[154],"with":[155,280],"halothane":[156],"those":[158],"thiopental.":[160],"RESULTS:":[161],"Preischemic":[162],"administration":[163,180],"at":[166,181],"all":[167,211],"decreased":[169],"risks":[171],"(P":[176,242],"<":[177,243],"0.01).":[178,244],"Post-ischemic":[179],"dosage":[183],"2":[185],"mg.kg-1.min-1":[186],"60":[188],"protected":[190],"neurons,":[191],"but":[192],"same":[194],"dose":[195,288],"10":[197],"did":[199,251],"not":[200,252],"ameliorate":[201],"cell":[203],"injury.":[204],"Forebrain":[205],"marked":[208],"increases":[209,234],"acids":[213],"to":[215,301],"6":[216],"start":[220],"recirculation":[222],"gerbils,":[226],"whereas":[227],"anesthesia":[229,258],"(2":[230],"mg.kg-1.min-1)":[231],"reduced":[232,266],"these":[233,255],"throughout":[235],"experimental":[237],"period,":[238],"except":[239],"glycine":[241],"initiation":[246],"reflow":[250],"markedly":[253],"diminish":[254],"increases.":[256],"Thiopental":[257,271],"prolonged":[259],"onset":[261],"its":[267],"maximal":[268],"amplitude.":[269],"CONCLUSIONS:":[270],"helps":[272],"brain":[275],"from":[276],"although":[278],"treatment":[279,297],"this":[281],"agent":[282],"requires":[285],"larger":[287],"than":[289],"that":[290],"ischemia.":[292],"effect":[294],"preischemic":[296],"may":[298],"be":[299],"related":[300],"suppression":[303],"shift.":[314]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}