{"id":"https://openalex.org/W2014830331","doi":"https://doi.org/10.1007/bf03259235","title":"Multiple Oral Dose Pharmacokinetic and Pharmacodynamic Study of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Volunteers","display_name":"Multiple Oral Dose Pharmacokinetic and Pharmacodynamic Study of a Sustained-Release Formulation of Bunazosin (E1015) in Healthy Volunteers","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W2014830331","doi":"https://doi.org/10.1007/bf03259235","mag":"2014830331"},"language":"en","primary_location":{"id":"doi:10.1007/bf03259235","doi":"https://doi.org/10.1007/bf03259235","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03259235","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004619249","display_name":"Nobumichi Morishita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobumichi Morishita","raw_affiliation_strings":["Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","Eisai Co., LTD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Co., LTD","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112063846","display_name":"Yoshiro Tomono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiro Tomono","raw_affiliation_strings":["Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","Eisai Co., LTD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Co., LTD","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiro Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55881946","display_name":"Eisai (Japan)","ror":"https://ror.org/04vvh7p27","country_code":"JP","type":"company","lineage":["https://openalex.org/I55881946"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Hasegawa","raw_affiliation_strings":["Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","Eisai Co., LTD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Pharmacology and Biostatistics, Eisai Co., Ltd, Koishikawa 4-6-10, Bunkyo-ku, Tokyo, 112-88, Japan","institution_ids":["https://openalex.org/I55881946"]},{"raw_affiliation_string":"Eisai Co., LTD","institution_ids":["https://openalex.org/I55881946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067393840","display_name":"Paul Branagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148122","display_name":"Eisai (United Kingdom)","ror":"https://ror.org/054j7wb83","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210148122","https://openalex.org/I55881946"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Branagan","raw_affiliation_strings":["Hammersmith International Centre, Eisai Europe Ltd, Commonwealth House, London, England","Eisai Europe Ltd, Commonwealth House"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hammersmith International Centre, Eisai Europe Ltd, Commonwealth House, London, England","institution_ids":["https://openalex.org/I4210148122"]},{"raw_affiliation_string":"Eisai Europe Ltd, Commonwealth House","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17543658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"6","first_page":"302","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bunazosin","display_name":"bunazosin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9390000104904175},{"id":"https://openalex.org/keywords/multiple-oral-dosing","display_name":"multiple oral dosing","score":0.890999972820282},{"id":"https://openalex.org/keywords/steady-state-plasma-concentration","display_name":"steady-state plasma concentration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiac-index","display_name":"cardiac index","score":0.9760000109672546},{"id":"https://openalex.org/keywords/renal-artery-blood-flow","display_name":"renal artery blood flow","score":0.9670000076293945},{"id":"https://openalex.org/keywords/stroke-volume-index","display_name":"stroke volume index","score":0.8790000081062317},{"id":"https://openalex.org/keywords/electrocardiographic-changes","display_name":"electrocardiographic changes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.6990000009536743},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8246252536773682},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7651583552360535},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.596721887588501},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5320093631744385},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.501990795135498},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.415849506855011},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41124919056892395},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4102003574371338},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3959053158760071},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2780681848526001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.252878338098526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/bf03259235","doi":"https://doi.org/10.1007/bf03259235","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf03259235","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1973413920","https://openalex.org/W1980813465","https://openalex.org/W1981871828","https://openalex.org/W2003376830","https://openalex.org/W2003463204","https://openalex.org/W2018648730","https://openalex.org/W2030510796","https://openalex.org/W2079332080","https://openalex.org/W4243903114"],"related_works":["https://openalex.org/W1973510549","https://openalex.org/W96292940","https://openalex.org/W2406405744","https://openalex.org/W2401578706","https://openalex.org/W2001670720","https://openalex.org/W2028556750","https://openalex.org/W2403031109","https://openalex.org/W2581707556","https://openalex.org/W2462713440","https://openalex.org/W1969721891"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}