{"id":"https://openalex.org/W2014817409","doi":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","title":"A synthetic hemoregulatory peptide (HP5B) inhibits human myelopoietic colony formation (CFU\u2010GM) but not leukocyte phagocytosis in vitro","display_name":"A synthetic hemoregulatory peptide (HP5B) inhibits human myelopoietic colony formation (CFU\u2010GM) but not leukocyte phagocytosis in vitro","publication_year":1987,"publication_date":"1987-09-01","ids":{"openalex":"https://openalex.org/W2014817409","doi":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","mag":"2014817409","pmid":"https://pubmed.ncbi.nlm.nih.gov/3678477"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0609.1987.tb00767.x","doi":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113659506","display_name":"Ole Didrik L\u00e6rum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Ole Didrik Laerum","raw_affiliation_strings":["Gade Institute, Department of Pathology, University of Bergen, Norway","\u2020The Gade Institute, Department of Pathology, University of Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gade Institute, Department of Pathology, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"\u2020The Gade Institute, Department of Pathology, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009674127","display_name":"Olav Sletvold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Olav Sletvold","raw_affiliation_strings":["The Gade Institute, Department of Pathology, University of Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gade Institute, Department of Pathology, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111642567","display_name":"Robert Bjerknes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Robert Bjerknes","raw_affiliation_strings":["The Gade Institute, Department of Pathology, University of Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Gade Institute, Department of Pathology, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068533377","display_name":"Walter R. Paukovits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Walter R. Paukovits","raw_affiliation_strings":["Institute for Tumor Biology/Cancer Research, University of Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Tumor Biology/Cancer Research, University of Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113659506"],"corresponding_institution_ids":["https://openalex.org/I4432739"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":1.9221,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85250129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"3","first_page":"259","last_page":"266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.7599999904632568},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.8140000104904175},{"id":"https://openalex.org/keywords/colony-formation-inhibition","display_name":"colony formation inhibition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/granulocytes","display_name":"granulocytes","score":0.8560000061988831},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-marrow-cells","display_name":"bone marrow cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.47999998927116394},{"id":"https://openalex.org/keywords/dose-dependent-inhibition","display_name":"dose-dependent inhibition","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8966083526611328},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.7732837200164795},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.6981383562088013},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.681118905544281},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5792502760887146},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5735181570053101},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5240195989608765},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5155839323997498},{"id":"https://openalex.org/C2777279920","wikidata":"https://www.wikidata.org/wiki/Q2931384","display_name":"CFU-GM","level":4,"score":0.4663723111152649},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4614499807357788},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.4590214192867279},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45106369256973267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4429877996444702},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4293588101863861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3921283483505249},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3338952958583832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3010362982749939},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2777770757675171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26012271642684937},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13448703289031982},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11334154009819031},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08325842022895813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0609.1987.tb00767.x","doi":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1987.tb00767.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:3678477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3678477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310758","display_name":"Kreftforeningen","ror":"https://ror.org/01925vb10"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W10410179","https://openalex.org/W45183960","https://openalex.org/W212742048","https://openalex.org/W216302928","https://openalex.org/W620118350","https://openalex.org/W1605555448","https://openalex.org/W1949439014","https://openalex.org/W1980888686","https://openalex.org/W1984047492","https://openalex.org/W1991073760","https://openalex.org/W1995966923","https://openalex.org/W1997192444","https://openalex.org/W2009567556","https://openalex.org/W2037960160","https://openalex.org/W2041528759","https://openalex.org/W2057388827","https://openalex.org/W2072884289","https://openalex.org/W2076001294","https://openalex.org/W2127768924","https://openalex.org/W2140547471","https://openalex.org/W2149439889","https://openalex.org/W2229437028","https://openalex.org/W2274095866","https://openalex.org/W2312366956","https://openalex.org/W2330332384","https://openalex.org/W2396087106","https://openalex.org/W2416869289","https://openalex.org/W4210967354"],"related_works":["https://openalex.org/W2127768924","https://openalex.org/W2105032899","https://openalex.org/W2416869289","https://openalex.org/W2037960160","https://openalex.org/W2312366956","https://openalex.org/W2464953922","https://openalex.org/W2057388827","https://openalex.org/W157698654","https://openalex.org/W2054662266","https://openalex.org/W2472661247"],"abstract_inverted_index":{"A":[0,49],"synthetic":[1],"analog":[2],"of":[3,43,52,59,88,98,105,124,128,131,155],"a":[4,141],"hemoregulatory":[5],"peptide":[6,117],"associated":[7],"with":[8,148],"mature":[9],"human":[10,20,37],"granulocyte":[11],"(HP5B)":[12],"has":[13,29],"been":[14,30],"investigated":[15],"for":[16,32,63],"inhibitory":[17,82],"effects":[18,33,83],"on":[19,34,121,144,151],"myelopoietic":[21],"stem":[22],"cells":[23,62],"in":[24,70],"vitro.":[25],"In":[26],"addition,":[27],"it":[28],"tested":[31],"phagocytosis":[35,125],"by":[36,41,126],"granulocytes":[38,159],"and":[39,109,160],"monocytes":[40],"use":[42],"an":[44],"automatic":[45],"flow":[46],"cytometric":[47],"method.":[48],"dose-dependent":[50],"inhibition":[51,89],"colony":[53],"formation":[54],"was":[55,104,113],"found":[56],"after":[57],"preincubation":[58],"bone":[60],"marrow":[61],"1":[64],"h":[65],"at":[66],"37":[67],"degrees":[68],"C":[69],"the":[71,99,110,122,129,145,152,158],"range":[72],"10(7)":[73,114],"-10(-11)":[74],"mol/l.":[75,115],"Above":[76],"or":[77,135],"below":[78],"these":[79],"concentrations,":[80],"no":[81,119,149],"were":[84],"seen.":[85],"The":[86,116],"degree":[87],"varied":[90],"from":[91],"experiment":[92],"to":[93],"experiment,":[94],"indicating":[95],"variable":[96],"responsiveness":[97],"donor":[100],"cells.":[101],"Maximal":[102],"effect":[103,120,143,150],"magnitude":[106],"90%":[107],"inhibition,":[108],"optimal":[111],"dose":[112],"had":[118],"kinetics":[123],"measurements":[127],"uptake":[130],"fluorescent":[132],"Zymosan":[133],"particles":[134],"Staphylococcus":[136],"aureus.":[137],"This":[138],"may":[139],"indicate":[140],"selective":[142],"precursor":[146],"cells,":[147],"functional":[153],"state":[154],"their":[156],"progeny,":[157],"monocytes.":[161]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
