{"id":"https://openalex.org/W2014801508","doi":"https://doi.org/10.1097/coh.0b013e32832f4a4d","title":"Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?","display_name":"Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?","publication_year":2009,"publication_date":"2009-08-15","ids":{"openalex":"https://openalex.org/W2014801508","doi":"https://doi.org/10.1097/coh.0b013e32832f4a4d","mag":"2014801508","pmid":"https://pubmed.ncbi.nlm.nih.gov/20048696","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2879149"},"language":"en","primary_location":{"id":"doi:10.1097/coh.0b013e32832f4a4d","doi":"https://doi.org/10.1097/coh.0b013e32832f4a4d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/coh.0b013e32832f4a4d","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2879149","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004036928","display_name":"David C. Montefiori","orcid":"https://orcid.org/0000-0003-0856-6319","observed_orcids":["https://orcid.org/0000-0003-0856-6319"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C Montefiori","raw_affiliation_strings":["Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA","to David C. Montefiori, PhD, Laboratory for AIDS Vaccine Research & Development, Department of Surgery, Box 2926, Duke University Medical Center, Durham, NC 27710, USA Tel: +1 919 684 5278; fax: +1 919 684 4288; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +1 919 684 4288","to David C. Montefiori, PhD, Laboratory for AIDS Vaccine Research & Development, Department of Surgery, Box 2926, Duke University Medical Center, Durham, NC 27710, USA Tel: +1 919 684 5278"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"to David C. Montefiori, PhD, Laboratory for AIDS Vaccine Research & Development, Department of Surgery, Box 2926, Duke University Medical Center, Durham, NC 27710, USA Tel: +1 919 684 5278; fax: +1 919 684 4288; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +1 919 684 4288","institution_ids":[]},{"raw_affiliation_string":"to David C. Montefiori, PhD, Laboratory for AIDS Vaccine Research & Development, Department of Surgery, Box 2926, Duke University Medical Center, Durham, NC 27710, USA Tel: +1 919 684 5278","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071657202","display_name":"John R. Mascola","orcid":"https://orcid.org/0000-0002-5293-4695","observed_orcids":["https://orcid.org/0000-0002-5293-4695"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405268911","display_name":"Vaccine Research Center","ror":"https://ror.org/02fve6a73","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405268911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R Mascola","raw_affiliation_strings":["Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405268911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004036928"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":null,"apc_paid":null,"fwci":1.1401,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.7283237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"4","issue":"5","first_page":"347","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.800000011920929},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.7979999780654907},{"id":"https://openalex.org/keywords/b-cell-response","display_name":"B cell response","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cd4-binding-site","display_name":"CD4 binding site","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gp120","display_name":"gp120","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hiv-1-subtypes","display_name":"HIV-1 subtypes","score":0.6779999732971191},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.5490000247955322},{"id":"https://openalex.org/keywords/antibody-epitopes","display_name":"antibody epitopes","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8393137454986572},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7275506854057312},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7038077712059021},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6878892779350281},{"id":"https://openalex.org/C2909828532","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"AIDS Vaccines","level":4,"score":0.5743511915206909},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.5621100664138794},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5487410426139832},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.5293508172035217},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5104480981826782},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4410087466239929},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3486345410346985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3342905640602112},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.15432953834533691}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056738","descriptor_name":"Cross Protection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/coh.0b013e32832f4a4d","doi":"https://doi.org/10.1097/coh.0b013e32832f4a4d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/coh.0b013e32832f4a4d","pdf_url":null,"source":{"id":"https://openalex.org/S106953758","display_name":"Current Opinion in HIV and AIDS","issn_l":"1746-630X","issn":["1746-630X","1746-6318"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in HIV and AIDS","raw_type":"journal-article"},{"id":"pmid:20048696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20048696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in HIV and AIDS","raw_type":"Editorial"},{"id":"pmh:oai:pubmedcentral.nih.gov:2879149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2879149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin HIV AIDS","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2879149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2879149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin HIV AIDS","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7803569706","display_name":"Primate Core Immunology - Virol. Lab.: Humoral Imm. Lab.","funder_award_id":"n01ai30034-15-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8107561751","display_name":"HIV Vaccine Development","funder_award_id":"R13AI053895","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8464176703","display_name":null,"funder_award_id":"N01 AI030034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W196933227","https://openalex.org/W1528520360","https://openalex.org/W1565279052","https://openalex.org/W1594804329","https://openalex.org/W1635348995","https://openalex.org/W1794879226","https://openalex.org/W1938402363","https://openalex.org/W1972385943","https://openalex.org/W1973149664","https://openalex.org/W1990745725","https://openalex.org/W1991539551","https://openalex.org/W1995355944","https://openalex.org/W1997677784","https://openalex.org/W2000361373","https://openalex.org/W2005860294","https://openalex.org/W2006483986","https://openalex.org/W2013330052","https://openalex.org/W2015491589","https://openalex.org/W2018123062","https://openalex.org/W2020100193","https://openalex.org/W2030129290","https://openalex.org/W2057961805","https://openalex.org/W2058632331","https://openalex.org/W2060679290","https://openalex.org/W2065329551","https://openalex.org/W2073421051","https://openalex.org/W2075775510","https://openalex.org/W2081291921","https://openalex.org/W2084310667","https://openalex.org/W2090763940","https://openalex.org/W2095910488","https://openalex.org/W2096010144","https://openalex.org/W2096387523","https://openalex.org/W2097594050","https://openalex.org/W2102548388","https://openalex.org/W2103712192","https://openalex.org/W2104823480","https://openalex.org/W2105903892","https://openalex.org/W2110287237","https://openalex.org/W2110499527","https://openalex.org/W2116058470","https://openalex.org/W2124935744","https://openalex.org/W2128439031","https://openalex.org/W2137939749","https://openalex.org/W2138634802","https://openalex.org/W2152399881","https://openalex.org/W2153163225","https://openalex.org/W2157210912","https://openalex.org/W2159211452","https://openalex.org/W2168919280","https://openalex.org/W2172063653","https://openalex.org/W2177434887"],"related_works":["https://openalex.org/W2134890041","https://openalex.org/W7100605305","https://openalex.org/W2013974444","https://openalex.org/W2171536421","https://openalex.org/W2388181995","https://openalex.org/W2804113494","https://openalex.org/W1971233211","https://openalex.org/W2022229620","https://openalex.org/W1991436594","https://openalex.org/W2096367542"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"This":[3],"review":[4],"describes":[5],"some":[6,104],"of":[7,18,58,66,88,97,105,149,157],"the":[8,16,40,67,98,113,146,173],"major":[9],"obstacles":[10],"that":[11,78,103,127,175],"have":[12,61,76],"impeded":[13],"progress":[14],"in":[15,39,43,71,112,154],"development":[17],"an":[19,137],"effective":[20,138],"neutralizing":[21,68,91,139,151],"antibody-based":[22,140],"HIV-1":[23,141],"vaccine":[24,142,181],"and":[25,53,166],"explains":[26],"why":[27],"it":[28],"may":[29],"be":[30,82,130],"possible":[31],"to":[32,55,84,129,178],"overcome":[33],"these":[34,106],"obstacles.":[35],"A":[36],"renewed":[37],"interest":[38],"B-cell":[41],"response":[42,70,164],"HIV-1-infected":[44,72,158],"individuals":[45],"is":[46,143],"emphasized.":[47],"RECENT":[48],"FINDINGS:":[49],"New":[50],"assay":[51],"technologies":[52],"access":[54],"large":[56],"numbers":[57],"clinical":[59],"specimens":[60],"permitted":[62],"a":[63,155],"detailed":[64],"assessment":[65],"antibody":[69,152],"individuals.":[73,159],"Recent":[74],"studies":[75],"demonstrated":[77],"B":[79],"cells":[80],"can":[81],"stimulated":[83],"generate":[85],"high":[86],"titers":[87],"broadly":[89],"cross-reactive":[90],"antibodies":[92,107],"against":[93,110,125],"multiple":[94],"genetic":[95],"subtypes":[96],"virus.":[99],"Preliminary":[100],"evidence":[101],"suggests":[102],"are":[108,123,169,176],"directed":[109,124],"epitopes":[111,126,168],"CD4":[114],"binding":[115],"site":[116],"on":[117,161],"monomeric":[118],"gp120,":[119],"whereas":[120],"many":[121],"others":[122],"remain":[128],"identified.":[131],"SUMMARY:":[132],"The":[133],"rationale":[134],"for":[135],"pursuing":[136],"strengthened":[144],"by":[145],"recent":[147],"demonstration":[148],"potent":[150],"responses":[153],"subset":[156],"Information":[160],"how":[162],"this":[163],"develops":[165],"what":[167],"targeted":[170],"could":[171],"provide":[172],"insights":[174],"needed":[177],"design":[179],"improved":[180],"strategies.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":16}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
