{"id":"https://openalex.org/W2014799631","doi":"https://doi.org/10.1165/ajrcmb.24.5.4265","title":"Lipopolysaccharide Inhibits the Late-Phase Response to Allergen by Altering Nitric Oxide Synthase Activity and Interleukin-10","display_name":"Lipopolysaccharide Inhibits the Late-Phase Response to Allergen by Altering Nitric Oxide Synthase Activity and Interleukin-10","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2014799631","doi":"https://doi.org/10.1165/ajrcmb.24.5.4265","mag":"2014799631","pmid":"https://pubmed.ncbi.nlm.nih.gov/11350836"},"language":"en","primary_location":{"id":"doi:10.1165/ajrcmb.24.5.4265","doi":"https://doi.org/10.1165/ajrcmb.24.5.4265","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.24.5.4265","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Lipopolysaccharide_inhibits_the_late-phase_response_to_allergen_by_altering_nitric_oxide_synthase_activity_and_interleukin-10/20611728","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012344066","display_name":"Meri K. Tuli\u0107","orcid":"https://orcid.org/0000-0002-2661-2369","observed_orcids":["https://orcid.org/0000-0002-2661-2369"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meri K. Tuli\u0107","raw_affiliation_strings":["Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030526109","display_name":"Darryl A. Knight","orcid":"https://orcid.org/0000-0002-4064-6127","observed_orcids":["https://orcid.org/0000-0002-4064-6127"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Darryl A. Knight","raw_affiliation_strings":["Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017272011","display_name":"Patrick G. Holt","orcid":"https://orcid.org/0000-0003-1193-0935","observed_orcids":["https://orcid.org/0000-0003-1193-0935"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick G. Holt","raw_affiliation_strings":["Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048175603","display_name":"Peter David Sly","orcid":"https://orcid.org/0000-0001-6305-2201","observed_orcids":["https://orcid.org/0000-0001-6305-2201"]},"institutions":[{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter D. Sly","raw_affiliation_strings":["Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Sciences and Cell Biology, Institute for Child Health Research, Center for Child Health Research; and Department of Medicine, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I177877127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177877127"],"apc_list":null,"apc_paid":null,"fwci":1.9041,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.84397689,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"5","first_page":"640","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.996999979019165},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.5709999799728394},{"id":"https://openalex.org/keywords/allergic-airway-inflammation","display_name":"allergic airway inflammation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9470000267028809},{"id":"https://openalex.org/keywords/constitutive-nitric-oxide-synthase","display_name":"constitutive nitric oxide synthase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6309999823570251},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.6589999794960022},{"id":"https://openalex.org/keywords/allergen-sensitization","display_name":"allergen sensitization","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tracheal-explants","display_name":"tracheal explants","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lung-homogenate","display_name":"lung homogenate","score":0.6480000019073486},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.48899999260902405},{"id":"https://openalex.org/keywords/cytokine-kinetics","display_name":"cytokine kinetics","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7976876497268677},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7671216130256653},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.7614664435386658},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.681738555431366},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5203068256378174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5191208720207214},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5072638392448425},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47614240646362305},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.47008728981018066},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4478604793548584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36375856399536133},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2777308225631714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23518764972686768},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.23264911770820618},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012130","descriptor_name":"Respiratory Hypersensitivity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1165/ajrcmb.24.5.4265","doi":"https://doi.org/10.1165/ajrcmb.24.5.4265","is_oa":false,"landing_page_url":"https://doi.org/10.1165/ajrcmb.24.5.4265","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:11350836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11350836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/77695d0d-09a8-48ae-83a3-b4d9065b17a3","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/77695d0d-09a8-48ae-83a3-b4d9065b17a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306402523","display_name":"UWA Profiles and Research Repository (University of Western Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tulic, M K, Knight, D A, Holt, P & Sly, P 2001, 'Lipopolysaccharide inhibits the late-phase response to allergen by altering nitric oxide synthase activity and interleukin-10', American Journal of Respiratory Cell and Molecular Biology, vol. 24, pp. 640-646. https://doi.org/10.1165/ajrcmb.24.5.4265","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/20611728","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Lipopolysaccharide_inhibits_the_late-phase_response_to_allergen_by_altering_nitric_oxide_synthase_activity_and_interleukin-10/20611728","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/20611728","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Lipopolysaccharide_inhibits_the_late-phase_response_to_allergen_by_altering_nitric_oxide_synthase_activity_and_interleukin-10/20611728","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1487331723","https://openalex.org/W1494575416","https://openalex.org/W1516048300","https://openalex.org/W1552193172","https://openalex.org/W1573470869","https://openalex.org/W1866890560","https://openalex.org/W1907570975","https://openalex.org/W1930598094","https://openalex.org/W1994362051","https://openalex.org/W2016563876","https://openalex.org/W2017659011","https://openalex.org/W2022479530","https://openalex.org/W2023206309","https://openalex.org/W2026028736","https://openalex.org/W2027584634","https://openalex.org/W2030137451","https://openalex.org/W2034475016","https://openalex.org/W2038992843","https://openalex.org/W2059357525","https://openalex.org/W2065496684","https://openalex.org/W2066204045","https://openalex.org/W2076171364","https://openalex.org/W2083466222","https://openalex.org/W2084399363","https://openalex.org/W2092025680","https://openalex.org/W2092117527","https://openalex.org/W2101771134","https://openalex.org/W2105960411","https://openalex.org/W2126043069","https://openalex.org/W2128808828","https://openalex.org/W2131662651","https://openalex.org/W2140862987","https://openalex.org/W2141608117","https://openalex.org/W2154268935","https://openalex.org/W2158361318","https://openalex.org/W2159881353","https://openalex.org/W2160862908","https://openalex.org/W2161761876","https://openalex.org/W2185210951","https://openalex.org/W2191654227","https://openalex.org/W2310246579","https://openalex.org/W2342509036","https://openalex.org/W4231581694","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2090466609","https://openalex.org/W2167745729","https://openalex.org/W2355882751","https://openalex.org/W2046444150","https://openalex.org/W2003980550","https://openalex.org/W2140862987","https://openalex.org/W2033599821","https://openalex.org/W2317879231","https://openalex.org/W1978100104","https://openalex.org/W2086881305"],"abstract_inverted_index":{"We":[0],"have":[1,31,306],"previously":[2],"shown":[3,32,307],"that":[4,33,284],"exposure":[5,91,126,158,245,263],"of":[6,69,237,275,298,326],"sensitized":[7,72,123,133,190,227,241],"animals":[8,94,134,150,216,228,280],"to":[9,51,60,77,209,222,246,283,309,312,330],"lipopolysaccharide":[10],"(LPS)":[11],"18":[12,103,127,181,197,248],"h":[13,88,118,128,155,168,182,198,249,260],"after":[14,89,119,129,156,199,250,261],"ovalbumin":[15],"(OVA)":[16],"challenge":[17,121,131,201],"inhibits":[18],"late-airway":[19],"response":[20],"(LAR).":[21],"Using":[22],"relatively":[23],"selective":[24],"nitric":[25],"oxide":[26],"synthase":[27],"(NOS)":[28],"inhibitors":[29,304],"we":[30,48],"LPS":[34,90,125,157,247,262,308],"upregulates":[35],"inducible":[36],"NOS":[37,42,53,139,317],"(iNOS)":[38],"and":[39,59,73,83,101,175,242,273,305],"downregulates":[40],"constitutive":[41],"(cNOS)":[43],"activity.":[44],"In":[45,148,189,239],"this":[46,337],"study":[47],"set":[49],"out":[50],"quantitate":[52],"isoenzyme":[54,140,303,318],"activity":[55,80,85],"in":[56,66,92,122,132,138,214,226,256,278,286,299,316,336],"lung":[57],"homogenates":[58],"measure":[61],"ex":[62],"vivo":[63,300],"interleukin":[64],"(IL)-10":[65],"tracheal":[67],"explants":[68],"naive":[70,93,149,215,287],"or":[71,110],"OVA-challenged":[74,243],"rats":[75],"exposed":[76],"LPS.":[78],"iNOS":[79],"was":[81,152,193,281],"increased":[82,153,195],"cNOS":[84],"reduced":[86],"6":[87],"(n":[95,104,112,142,159,169,183,202,264],"=":[96,105,113,143,160,170,184,203,265],"6,":[97],"P":[98,107,115,145,162,172,186,205,267],"<":[99,108,116,146,163,173,187,206,268],"0.001)":[100,109,117],"at":[102,166,180,258],"5,":[106,114,144,161,266],"24":[111],"OVA":[120,130,200,251],"animals.":[124],"reversed":[135],"OVA-induced":[136,314],"changes":[137,315],"activities":[141,319],"0.001).":[147,207,269],"IL-10":[151,192,212,219,257,276,327],"1":[154],"0.001),":[164,174],"peaked":[165],"3":[167,259],"9,":[171],"remained":[176],"elevated":[177],"above":[178],"baseline":[179],"11,":[185,204],"0.05).":[188],"animals,":[191],"not":[194],"until":[196],"Due":[208],"the":[210,217,229,240,296],"rapid":[211],"increase":[213,255],"released":[218],"is":[220,328],"likely":[221],"be":[223,310],"preformed;":[224],"however,":[225],"results":[230,290],"are":[231],"consistent":[232],"with":[233],"de":[234],"novo":[235],"production":[236],"IL-10.":[238],"group,":[244],"produced":[252],"a":[253],"3-fold":[254],"The":[270],"time":[271],"course":[272],"kinetics":[274],"release":[277,325],"those":[279],"similar":[282],"seen":[285],"rats.":[288],"These":[289],"support":[291],"our":[292],"previous":[293],"conclusions":[294],"on":[295],"basis":[297],"studies":[301],"using":[302],"able":[311],"reverse":[313],"during":[320],"an":[321,332],"established":[322],"LAR.":[323],"LPS-induced":[324],"thought":[329],"play":[331],"important":[333],"immunomodulatory":[334],"role":[335],"model.":[338]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}