{"id":"https://openalex.org/W2014796351","doi":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","title":"Response of Elevated Methylmalonic Acid to Three Dose Levels of Oral Cobalamin in Older Adults","display_name":"Response of Elevated Methylmalonic Acid to Three Dose Levels of Oral Cobalamin in Older Adults","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2014796351","doi":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","mag":"2014796351","pmid":"https://pubmed.ncbi.nlm.nih.gov/12410896"},"language":"en","primary_location":{"id":"doi:10.1046/j.1532-5415.2002.50506.x","doi":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028674947","display_name":"Suparna Rajan","orcid":"https://orcid.org/0000-0002-0270-0874","observed_orcids":["https://orcid.org/0000-0002-0270-0874"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suparna Rajan","raw_affiliation_strings":["Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington, USA","Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington;","Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210094549"]},{"raw_affiliation_string":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington;","institution_ids":["https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110187597","display_name":"Jeffrey I. Wallace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey I. Wallace","raw_affiliation_strings":["Divisions of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038559041","display_name":"Kayla I. Brodkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210094549","display_name":"VA Puget Sound Health Care System","ror":"https://ror.org/00ky3az31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094549","https://openalex.org/I4210138024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayla I. Brodkin","raw_affiliation_strings":["Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington;","Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Veteran Affairs Puget Sound Health Care System, Seattle, Washington;","institution_ids":["https://openalex.org/I4210094549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069321664","display_name":"Shirley A.A. Beresford","orcid":"https://orcid.org/0000-0002-1631-3541","observed_orcids":["https://orcid.org/0000-0002-1631-3541"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley A. Beresford","raw_affiliation_strings":["Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056996183","display_name":"Robert H. Allen","orcid":"https://orcid.org/0000-0002-8583-6047","observed_orcids":["https://orcid.org/0000-0002-8583-6047"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Allen","raw_affiliation_strings":["Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; and","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013709045","display_name":"Sally P. Stabler","orcid":"https://orcid.org/0000-0001-9032-4436","observed_orcids":["https://orcid.org/0000-0001-9032-4436"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sally P. Stabler","raw_affiliation_strings":["Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado; and","institution_ids":["https://openalex.org/I4210087413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013709045"],"corresponding_institution_ids":["https://openalex.org/I4210087413"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":2.8012,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.89883363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"50","issue":"11","first_page":"1789","last_page":"1795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.9829999804496765},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6940000057220459},{"id":"https://openalex.org/keywords/methylmalonic-acid","display_name":"methylmalonic acid","score":0.890999972820282},{"id":"https://openalex.org/keywords/total-homocysteine","display_name":"total homocysteine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.7239999771118164},{"id":"https://openalex.org/keywords/multivitamins","display_name":"multivitamins","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780676250","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Cobalamin","level":3,"score":0.968784511089325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9646097421646118},{"id":"https://openalex.org/C2779821038","wikidata":"https://www.wikidata.org/wiki/Q239598","display_name":"Methylmalonic acid","level":3,"score":0.9277510643005371},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43736135959625244},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4087139070034027},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.3726615011692047}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008764","descriptor_name":"Methylmalonic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014805","descriptor_name":"Vitamin B 12","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014806","descriptor_name":"Vitamin B 12 Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1532-5415.2002.50506.x","doi":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1532-5415.2002.50506.x","pdf_url":null,"source":{"id":"https://openalex.org/S204183829","display_name":"Journal of the American Geriatrics Society","issn_l":"0002-8614","issn":["0002-8614","1532-5415"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"journal-article"},{"id":"pmid:12410896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12410896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Geriatrics Society","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.6735000014305115,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1079640152","display_name":"WEIGHT LOSS AND FAILURE TO THRIVE","funder_award_id":"5k08ag000615-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2304080428","display_name":"B12 Nutrition in the Aged","funder_award_id":"R01AG009834","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5262966690","display_name":null,"funder_award_id":"AG09834","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8745194570","display_name":null,"funder_award_id":"5K08AG00615","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W69397147","https://openalex.org/W1497580828","https://openalex.org/W1550111394","https://openalex.org/W1591638896","https://openalex.org/W1689606519","https://openalex.org/W1793110720","https://openalex.org/W1900838714","https://openalex.org/W1947205259","https://openalex.org/W1953523985","https://openalex.org/W1978853703","https://openalex.org/W1997421691","https://openalex.org/W2009717092","https://openalex.org/W2019157922","https://openalex.org/W2021156126","https://openalex.org/W2037970697","https://openalex.org/W2044043835","https://openalex.org/W2048896147","https://openalex.org/W2055525364","https://openalex.org/W2062125841","https://openalex.org/W2064337776","https://openalex.org/W2067018203","https://openalex.org/W2077725073","https://openalex.org/W2095892406","https://openalex.org/W2113681646","https://openalex.org/W2119262508","https://openalex.org/W2164518728","https://openalex.org/W2166608555","https://openalex.org/W2167908108","https://openalex.org/W2394952785","https://openalex.org/W2991826237","https://openalex.org/W4318598739"],"related_works":["https://openalex.org/W2085135218","https://openalex.org/W2079550255","https://openalex.org/W128775836","https://openalex.org/W2077725073","https://openalex.org/W4251080681","https://openalex.org/W2037970697","https://openalex.org/W2125669371","https://openalex.org/W1967050122","https://openalex.org/W1987775016","https://openalex.org/W2005684080"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Because":[1],"the":[2,169],"effects":[3],"of":[4,47,67,163,186,217],"lower-dose":[5],"oral":[6,22,113,195,218],"cobalamin":[7,14,122],"(Cbl)":[8],"supplements":[9,24],"on":[10],"older":[11,59,210],"people":[12,211],"with":[13,63,110,145,194,204],"deficiency":[15,92],"are":[16],"not":[17,154],"known,":[18],"we":[19],"determined":[20],"whether":[21],"Cbl":[23,65,91,196,219,237],"at":[25,135],"three":[26,48],"different":[27],"dose":[28,49,162,228],"levels":[29,66,157,175],"would":[30],"normalize":[31,155,221],"elevated":[32,191],"serum":[33,64,75,222],"methylmalonic":[34],"acid":[35],"(MMA)":[36],"and":[37,74,119,132,137,148,198,236],"total":[38],"homocysteine":[39],"(tHcy)":[40],"concentrations.":[41],"DESIGN:":[42],"Sequential":[43,107],"nonrandomized":[44],"intervention":[45],"study":[46,89],"levels.":[50],"SETTINGS:":[51],"Two":[52],"university-based":[53],"senior":[54],"care":[55],"clinics.":[56],"PARTICIPANTS:":[57],"Twenty-three":[58],"adults":[60],"(aged":[61],">/=65)":[62],"221":[68],"pmol/L":[69],"(300":[70],"pg/mL)":[71],"or":[72],"lower":[73],"MMA":[76,156,174],"greater":[77],"than":[78,214,229],"271":[79],"nmol/L":[80],"who":[81,189],"had":[82,190],"been":[83],"enrolled":[84],"in":[85,158,172,184,199,202,232],"a":[86,125,205,226],"previous":[87],"screening":[88],"for":[90,124],"(mean":[93],"age":[94],"79":[95],"+/-":[96],"9;":[97],"17":[98,102],"male,":[99],"6":[100,104],"female;":[101],"white,":[103],"other).":[105],"INTERVENTION:":[106],"daily":[108],"treatment":[109],"25":[111,146],"microg":[112,118,121,147,150,216],"cobalamin,":[114],"followed":[115],"by":[116],"100":[117,149,215],"1,000":[120,164],"each":[123,139],"6-week":[126,140],"period.":[127],"MEASUREMENTS:":[128],"Serum":[129,180],"MMA,":[130,223],"tHcy,":[131],"other":[133],"metabolites":[134],"baseline":[136],"after":[138],"dosing":[141],"interval.":[142],"RESULTS:":[143],"Treatment":[144],"lowered":[151],"but":[152],"did":[153],"most":[159,170,233],"subjects.":[160],"A":[161],"microg/day":[165],"proved":[166],"to":[167,176,220],"be":[168],"effective":[171],"lowering":[173],"within":[177],"normal":[178],"limits.":[179],"tHcy":[181,192],"was":[182],"normalized":[183],"six":[185],"11":[187],"subjects":[188],"pretreatment":[193],"alone":[197],"one":[200],"subject":[201],"combination":[203],"multivitamin.":[206],"CONCLUSIONS:":[207],"Most":[208],"Cbl-deficient":[209],"require":[212],"more":[213],"which":[224],"is":[225,230],"larger":[227],"available":[231],"standard":[234],"multivitamins":[235],"supplements.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}