{"id":"https://openalex.org/W2014795668","doi":"https://doi.org/10.1016/j.exger.2006.06.047","title":"Quantitative trait loci define genes and pathways underlying genetic variation in longevity","display_name":"Quantitative trait loci define genes and pathways underlying genetic variation in longevity","publication_year":2006,"publication_date":"2006-08-18","ids":{"openalex":"https://openalex.org/W2014795668","doi":"https://doi.org/10.1016/j.exger.2006.06.047","mag":"2014795668","pmid":"https://pubmed.ncbi.nlm.nih.gov/16919411"},"language":"en","primary_location":{"id":"doi:10.1016/j.exger.2006.06.047","doi":"https://doi.org/10.1016/j.exger.2006.06.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exger.2006.06.047","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010384852","display_name":"Robert J. Shmookler Reis","orcid":"https://orcid.org/0000-0002-4691-0734","observed_orcids":["https://orcid.org/0000-0002-4691-0734"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert J. Shmookler Reis","raw_affiliation_strings":["Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA. rjsr@uams.edu","Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA. rjsr@uams.edu","institution_ids":["https://openalex.org/I4210099013"]},{"raw_affiliation_string":"Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I4210099013"]},{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069326107","display_name":"Ping Kang","orcid":"https://orcid.org/0000-0001-5585-2903","observed_orcids":["https://orcid.org/0000-0001-5585-2903"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Kang","raw_affiliation_strings":["Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I4210099013"]},{"raw_affiliation_string":"Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039791222","display_name":"Srinivas Ayyadevara","orcid":"https://orcid.org/0000-0002-4572-6361","observed_orcids":["https://orcid.org/0000-0002-4572-6361"]},"institutions":[{"id":"https://openalex.org/I4210099013","display_name":"Central Arkansas Veterans Healthcare System","ror":"https://ror.org/01s5r6w32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099013","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Ayyadevara","raw_affiliation_strings":["Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I4210099013"]},{"raw_affiliation_string":"Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010384852"],"corresponding_institution_ids":["https://openalex.org/I4210099013","https://openalex.org/I79620101"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.1778,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.07936508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"10","first_page":"1046","last_page":"1054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8949999809265137},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.8080000281333923},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/longevity-genes","display_name":"longevity genes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.972000002861023},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mutagenesis-screen","display_name":"mutagenesis screen","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gene-identification","display_name":"gene identification","score":0.6460000276565552},{"id":"https://openalex.org/keywords/animal-models-of-aging","display_name":"animal models of aging","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8633162379264832},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.8330994844436646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6727030277252197},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.62166428565979},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.6136282682418823},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5960230827331543},{"id":"https://openalex.org/C21249469","wikidata":"https://www.wikidata.org/wiki/Q5433313","display_name":"Family-based QTL mapping","level":5,"score":0.5218750238418579},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.5156859159469604},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.508220911026001},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.5013513565063477},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.48001521825790405},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4568735659122467},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3937772214412689},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.3244929015636444},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.07091239094734192}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017238","descriptor_name":"Genes, Helminth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017344","descriptor_name":"Genes, Insect","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exger.2006.06.047","doi":"https://doi.org/10.1016/j.exger.2006.06.047","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.exger.2006.06.047","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:16919411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16919411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W1491447916","https://openalex.org/W1524525825","https://openalex.org/W1568460916","https://openalex.org/W1587592813","https://openalex.org/W1812816875","https://openalex.org/W1847670392","https://openalex.org/W1854368284","https://openalex.org/W1864995317","https://openalex.org/W1892634984","https://openalex.org/W1894443853","https://openalex.org/W1899108571","https://openalex.org/W1925964606","https://openalex.org/W1940904808","https://openalex.org/W1948123902","https://openalex.org/W1964798518","https://openalex.org/W1976382531","https://openalex.org/W1978587926","https://openalex.org/W1980046382","https://openalex.org/W1980054726","https://openalex.org/W1982376676","https://openalex.org/W1983740151","https://openalex.org/W1985551609","https://openalex.org/W1990276200","https://openalex.org/W1994161369","https://openalex.org/W1995869264","https://openalex.org/W1997145913","https://openalex.org/W1997732238","https://openalex.org/W1999459482","https://openalex.org/W2002622198","https://openalex.org/W2004244220","https://openalex.org/W2005381354","https://openalex.org/W2013742279","https://openalex.org/W2015518024","https://openalex.org/W2020423636","https://openalex.org/W2030130178","https://openalex.org/W2046989794","https://openalex.org/W2047683380","https://openalex.org/W2049009766","https://openalex.org/W2060814375","https://openalex.org/W2062048451","https://openalex.org/W2066455826","https://openalex.org/W2072129387","https://openalex.org/W2072288814","https://openalex.org/W2072374971","https://openalex.org/W2074541325","https://openalex.org/W2081267709","https://openalex.org/W2085772485","https://openalex.org/W2089106442","https://openalex.org/W2089818995","https://openalex.org/W2092254291","https://openalex.org/W2093935763","https://openalex.org/W2094231976","https://openalex.org/W2096541004","https://openalex.org/W2103745570","https://openalex.org/W2107871825","https://openalex.org/W2115658229","https://openalex.org/W2121593335","https://openalex.org/W2128285239","https://openalex.org/W2129529285","https://openalex.org/W2136080612","https://openalex.org/W2137096448","https://openalex.org/W2144005841","https://openalex.org/W2145007656","https://openalex.org/W2148728711","https://openalex.org/W2149702758","https://openalex.org/W2154675483","https://openalex.org/W2160464840","https://openalex.org/W2163285329","https://openalex.org/W2166371252","https://openalex.org/W2167567258","https://openalex.org/W2418518424","https://openalex.org/W2751862591","https://openalex.org/W2753908209","https://openalex.org/W4242752896","https://openalex.org/W6824876689"],"related_works":["https://openalex.org/W2015518024","https://openalex.org/W2411044028","https://openalex.org/W190533906","https://openalex.org/W1940904808","https://openalex.org/W2121593335","https://openalex.org/W1964798518","https://openalex.org/W4366737057","https://openalex.org/W2409077316","https://openalex.org/W2138037637","https://openalex.org/W1983740151"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}