{"id":"https://openalex.org/W2014784949","doi":"https://doi.org/10.1097/mbc.0b013e3282f0981f","title":"Effect of methimazole on warfarin anticoagulation in a case of Graves' disease","display_name":"Effect of methimazole on warfarin anticoagulation in a case of Graves' disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2014784949","doi":"https://doi.org/10.1097/mbc.0b013e3282f0981f","mag":"2014784949","pmid":"https://pubmed.ncbi.nlm.nih.gov/18180622"},"language":"en","primary_location":{"id":"doi:10.1097/mbc.0b013e3282f0981f","doi":"https://doi.org/10.1097/mbc.0b013e3282f0981f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0b013e3282f0981f","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation & Fibrinolysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109126170","display_name":"Fulya Ak\u0131n","orcid":"https://orcid.org/0009-0004-4026-1974","observed_orcids":["https://orcid.org/0009-0004-4026-1974"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fulya Akin","raw_affiliation_strings":["Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016885969","display_name":"G\u00fczin Fidan Yaylal\u0131","orcid":"https://orcid.org/0000-0003-0012-4700","observed_orcids":["https://orcid.org/0000-0003-0012-4700"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Guzin Fidan Yaylali","raw_affiliation_strings":["Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey","to Guzin Fidan Yaylali, MD, Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, K\u0131n\u0131kl\u0131 kampusu 20070 Kinikli, Denizli, Turkey Tel: +90 258 2118585/2223; fax: +90 258 2134922; e-mail: [email\u00a0protected]","e-mail: [email\u00a0protected]","fax: +90 258 2134922","to Guzin Fidan Yaylali, MD, Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, K\u0131n\u0131kl\u0131 kampusu 20070 Kinikli, Denizli, Turkey Tel: +90 258 2118585/2223"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]},{"raw_affiliation_string":"to Guzin Fidan Yaylali, MD, Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, K\u0131n\u0131kl\u0131 kampusu 20070 Kinikli, Denizli, Turkey Tel: +90 258 2118585/2223; fax: +90 258 2134922; e-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I48843708"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"fax: +90 258 2134922","institution_ids":[]},{"raw_affiliation_string":"to Guzin Fidan Yaylali, MD, Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, K\u0131n\u0131kl\u0131 kampusu 20070 Kinikli, Denizli, Turkey Tel: +90 258 2118585/2223","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114011368","display_name":"Mehmet Ba\u015ftemir","orcid":"https://orcid.org/0000-0002-0762-6052","observed_orcids":["https://orcid.org/0000-0002-0762-6052"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Bastemir","raw_affiliation_strings":["Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pamukkale University, School of Medicine, Department of Endocrinology and Metabolic Diseases, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112346096","display_name":"Burcu Yapar","orcid":"https://orcid.org/0000-0003-4755-2753","observed_orcids":["https://orcid.org/0000-0003-4755-2753"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Burcu Yapar","raw_affiliation_strings":["Department of Internal Medicine, Pamukkale University, Denizli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Pamukkale University, Denizli, Turkey","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016885969"],"corresponding_institution_ids":["https://openalex.org/I48843708"],"apc_list":null,"apc_paid":null,"fwci":0.5865,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70858452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"89","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.9259999990463257},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.8970000147819519},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.8299999833106995},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.746999979019165},{"id":"https://openalex.org/keywords/antithyroid-drugs","display_name":"antithyroid drugs","score":0.9449999928474426},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/thyrotoxicosis","display_name":"thyrotoxicosis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/thyroid-hormone-levels","display_name":"thyroid hormone levels","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8589968681335449},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.7955446243286133},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.6788920164108276},{"id":"https://openalex.org/C2776652619","wikidata":"https://www.wikidata.org/wiki/Q16483","display_name":"Graves' disease","level":3,"score":0.5984811186790466},{"id":"https://openalex.org/C2776606491","wikidata":"https://www.wikidata.org/wiki/Q1365501","display_name":"Antithyroid agent","level":4,"score":0.5930183529853821},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.49163228273391724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4897039234638214},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.43169182538986206},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.42126721143722534},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3252701759338379},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.21589204668998718}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013956","descriptor_name":"Antithyroid Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019934","descriptor_name":"International Normalized Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/mbc.0b013e3282f0981f","doi":"https://doi.org/10.1097/mbc.0b013e3282f0981f","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbc.0b013e3282f0981f","pdf_url":null,"source":{"id":"https://openalex.org/S118812467","display_name":"Blood Coagulation & Fibrinolysis","issn_l":"0957-5235","issn":["0957-5235","1473-5733"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Coagulation & Fibrinolysis","raw_type":"journal-article"},{"id":"pmid:18180622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18180622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W121555172","https://openalex.org/W181564901","https://openalex.org/W188812253","https://openalex.org/W1951795471","https://openalex.org/W2004986876","https://openalex.org/W2018787410","https://openalex.org/W2027151097","https://openalex.org/W2043615259","https://openalex.org/W2126270987","https://openalex.org/W2152428309","https://openalex.org/W2314427644","https://openalex.org/W2367131759","https://openalex.org/W4243225672","https://openalex.org/W4248098588"],"related_works":["https://openalex.org/W2115850286","https://openalex.org/W7099349733","https://openalex.org/W2086051452","https://openalex.org/W2043615259","https://openalex.org/W4415360285","https://openalex.org/W181564901","https://openalex.org/W2089554161","https://openalex.org/W2374429855","https://openalex.org/W3083089154","https://openalex.org/W1855218599"],"abstract_inverted_index":{"The":[0,60,187],"article":[1],"describes":[2],"a":[3,43,69,79,112],"case":[4],"of":[5,15,18,82,136,160,177,189,205],"Graves'":[6],"disease":[7],"treated":[8,63],"with":[9,34,58,64,111,149,195,223],"methimazole":[10,91,140],"and":[11,39,49,121,134,141,151,164,185],"examines":[12],"the":[13,132,137,165],"influence":[14],"methimazole-induced":[16],"alterations":[17],"thyroid":[19,54,125,162],"hormone":[20,126],"concentrations":[21,127],"during":[22],"warfarin":[23,65,120,142,150,248],"therapy.":[24,249],"A":[25,102],"22-year-old":[26],"woman":[27],"presented":[28],"at":[29],"our":[30],"endocrinology":[31],"outpatient":[32],"clinic":[33],"palpitations,":[35],"sweating,":[36],"fatigue,":[37],"tremors,":[38],"diarrhea.":[40],"She":[41],"had":[42,50],"pain":[44],"in":[45,107,179,193,245],"her":[46],"right":[47],"leg":[48],"difficulty":[51],"walking.":[52],"Her":[53],"profile":[55],"was":[56,62,92,99,105],"consistent":[57],"hyperthyroidism.":[59],"patient":[61],"5":[66],"mg":[67],"once":[68],"day":[70],"for":[71,75,242],"deep":[72],"vein":[73],"thrombosis":[74],"2":[76,108],"days.":[77],"Since":[78],"therapeutic":[80,113],"range":[81],"International":[83,114,166],"Normalized":[84,115,167],"Ratio":[85,116],"levels":[86],"could":[87],"not":[88,229],"be":[89,155,201,230,238],"achieved,":[90],"stopped":[93],"due":[94,232],"to":[95,173,200,233],"drug-drug":[96,234],"interaction.":[97],"Lithium":[98,169,236],"started":[100],"instead.":[101],"euthyroid":[103],"state":[104],"obtained":[106,231],"weeks":[109],"together":[110,222],"level.":[117],"Interactions":[118],"between":[119,139],"drugs":[122,153,197,211],"that":[123],"alter":[124],"have":[128,143],"been":[129,144],"reported;":[130],"however,":[131],"extent":[133],"significance":[135],"interaction":[138],"inadequately":[145],"described.":[146],"Concomitant":[147],"therapy":[148],"antithyroid":[152,210,224,243],"should":[154],"managed":[156],"by":[157],"frequent":[158],"monitoring":[159],"both":[161],"function":[163],"Ratio.":[168],"is":[170,198],"employed":[171],"only":[172],"provide":[174],"temporary":[175],"control":[176],"thyrotoxicosis":[178],"patients":[180,246],"who":[181],"cannot":[182],"take":[183],"thionamide":[184],"iodide.":[186],"administration":[188],"lithium":[190],"alone":[191],"or":[192,215],"combination":[194],"other":[196],"shown":[199],"an":[202,239],"effective":[203],"method":[204],"controlling":[206],"hyperthyroidism":[207],"when":[208],"conventional":[209],"show":[212],"adverse":[213],"effects":[214],"become":[216],"insufficient.":[217],"When":[218],"warfarins":[219],"are":[220],"used":[221],"medications,":[225],"adequate":[226],"anticoagulation":[227],"may":[228],"interactions.":[235],"can":[237],"alternative":[240],"drug":[241],"medication":[244],"on":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}