{"id":"https://openalex.org/W2014778419","doi":"https://doi.org/10.1016/j.cbi.2015.01.011","title":"Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-\u03baB","display_name":"Protective effects of the flavonoid hesperidin methyl chalcone in inflammation and pain in mice: Role of TRPV1, oxidative stress, cytokines and NF-\u03baB","publication_year":2015,"publication_date":"2015-01-21","ids":{"openalex":"https://openalex.org/W2014778419","doi":"https://doi.org/10.1016/j.cbi.2015.01.011","mag":"2014778419","pmid":"https://pubmed.ncbi.nlm.nih.gov/25617481"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbi.2015.01.011","doi":"https://doi.org/10.1016/j.cbi.2015.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbi.2015.01.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0009279715000174/pdf","source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0009279715000174/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035877999","display_name":"Felipe Almeida Pinho-Ribeiro","orcid":"https://orcid.org/0000-0003-4264-9839","observed_orcids":["https://orcid.org/0000-0003-4264-9839"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Felipe A. Pinho-Ribeiro","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006346787","display_name":"Miriam Sayuri Hohmann","orcid":"https://orcid.org/0000-0003-2667-3919","observed_orcids":["https://orcid.org/0000-0003-2667-3919"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Miriam S.N. Hohmann","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020393806","display_name":"S\u00e9rgio M. Borghi","orcid":"https://orcid.org/0000-0002-6978-7505","observed_orcids":["https://orcid.org/0000-0002-6978-7505"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sergio M. Borghi","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110053762","display_name":"Ana Carla Zarpelon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana C. Zarpelon","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063508097","display_name":"Carla F.S. Guazelli","orcid":"https://orcid.org/0000-0002-6124-8371","observed_orcids":["https://orcid.org/0000-0002-6124-8371"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carla F.S. Guazelli","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011135978","display_name":"Mar\u00edlia F. Manchope","orcid":"https://orcid.org/0000-0003-2882-6536","observed_orcids":["https://orcid.org/0000-0003-2882-6536"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marilia F. Manchope","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064208545","display_name":"R\u00fabia Casagrande","orcid":"https://orcid.org/0000-0002-2296-1668","observed_orcids":["https://orcid.org/0000-0002-2296-1668"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rubia Casagrande","raw_affiliation_strings":["Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Londrina Londrina-UEL, Avenida Robert Koch, 60, Hospital Universit\u00e1rio, 86038-350 Londrina, Paran\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Estadual de Londrina Londrina-UEL, Avenida Robert Koch, 60, Hospital Universit\u00e1rio, 86038-350 Londrina, Paran\u00e1, Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078024039","display_name":"Waldiceu Aparecido Verri Jr","orcid":"https://orcid.org/0000-0003-2756-9283","observed_orcids":["https://orcid.org/0000-0003-2756-9283"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Waldiceu A. Verri","raw_affiliation_strings":["Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil. Electronic address: waldiceujr@yahoo.com.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias Patol\u00f3gicas, Universidade Estadual de Londrina-UEL, Rod. Celso Garcia Cid, Km 380, PR445, 86057-970, Cx. Postal 10.011, Londrina, Paran\u00e1, Brazil. Electronic address: waldiceujr@yahoo.com.br","institution_ids":["https://openalex.org/I127110123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078024039"],"corresponding_institution_ids":["https://openalex.org/I127110123"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":9.3462,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.98580048,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"228","issue":null,"first_page":"88","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14194","display_name":"Bioactive Compounds in Plants","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9480000138282776},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8009999990463257},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9470000267028809},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.8289999961853027},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.8709999918937683},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.8899999856948853},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.7760000228881836},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.777999997138977},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.921999990940094},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9779999852180481},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.5009999871253967},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.793325662612915},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7382413744926453},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7113837003707886},{"id":"https://openalex.org/C2776128092","wikidata":"https://www.wikidata.org/wiki/Q385937","display_name":"Hesperidin","level":3,"score":0.6488736271858215},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6418583393096924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5997756719589233},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.5352991223335266},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5349394679069519},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.49369320273399353},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.4802870452404022},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.4683237671852112},{"id":"https://openalex.org/C2780764945","wikidata":"https://www.wikidata.org/wiki/Q899416","display_name":"Chalcone","level":2,"score":0.44153615832328796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37307605147361755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29507219791412354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28534626960754395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22612279653549194},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.08473187685012817},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.08210200071334839},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0705917477607727},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbi.2015.01.011","doi":"https://doi.org/10.1016/j.cbi.2015.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbi.2015.01.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0009279715000174/pdf","source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:25617481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25617481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cbi.2015.01.011","doi":"https://doi.org/10.1016/j.cbi.2015.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cbi.2015.01.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0009279715000174/pdf","source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322771","display_name":"Secret\u00e1rio de Ci\u00eancia, Tecnologia e Ensino Superior, Governo do Estado de Parana","ror":"https://ror.org/05nyhnc56"},{"id":"https://openalex.org/F4320322772","display_name":"Funda\u00e7\u00e3o Arauc\u00e1ria","ror":"https://ror.org/02r7nkw81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014778419.pdf","grobid_xml":"https://content.openalex.org/works/W2014778419.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W6703600","https://openalex.org/W79914589","https://openalex.org/W180625481","https://openalex.org/W257443845","https://openalex.org/W300812367","https://openalex.org/W1206532208","https://openalex.org/W1543782039","https://openalex.org/W1547774099","https://openalex.org/W1946202333","https://openalex.org/W1972864851","https://openalex.org/W1974254997","https://openalex.org/W1975175496","https://openalex.org/W1980940100","https://openalex.org/W1984228225","https://openalex.org/W1986863961","https://openalex.org/W2000147012","https://openalex.org/W2001933690","https://openalex.org/W2005745212","https://openalex.org/W2006612420","https://openalex.org/W2007755013","https://openalex.org/W2020358486","https://openalex.org/W2020908426","https://openalex.org/W2026195388","https://openalex.org/W2029647910","https://openalex.org/W2030994794","https://openalex.org/W2031468866","https://openalex.org/W2039246411","https://openalex.org/W2041354200","https://openalex.org/W2046296795","https://openalex.org/W2048529544","https://openalex.org/W2052487974","https://openalex.org/W2054214002","https://openalex.org/W2062393357","https://openalex.org/W2065432788","https://openalex.org/W2069953418","https://openalex.org/W2069995516","https://openalex.org/W2070017187","https://openalex.org/W2072253551","https://openalex.org/W2074506689","https://openalex.org/W2076975188","https://openalex.org/W2077305107","https://openalex.org/W2079613593","https://openalex.org/W2082908786","https://openalex.org/W2085137779","https://openalex.org/W2088584036","https://openalex.org/W2092864619","https://openalex.org/W2093585097","https://openalex.org/W2105542732","https://openalex.org/W2110228005","https://openalex.org/W2113530784","https://openalex.org/W2115158780","https://openalex.org/W2132126635","https://openalex.org/W2143541397","https://openalex.org/W2149608846","https://openalex.org/W2158136044","https://openalex.org/W2162516508","https://openalex.org/W2171223432","https://openalex.org/W2232680822","https://openalex.org/W2236227678","https://openalex.org/W2283901033","https://openalex.org/W2322559033","https://openalex.org/W2324251142","https://openalex.org/W2399311092","https://openalex.org/W2409410612","https://openalex.org/W6610656063","https://openalex.org/W6675966428","https://openalex.org/W6712828496"],"related_works":["https://openalex.org/W3006437928","https://openalex.org/W2322559033","https://openalex.org/W3095410457","https://openalex.org/W2604193264","https://openalex.org/W2593697738","https://openalex.org/W2900649986","https://openalex.org/W4409832307","https://openalex.org/W956454888","https://openalex.org/W2284360474","https://openalex.org/W2089679971"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}