{"id":"https://openalex.org/W2014778338","doi":"https://doi.org/10.1002/art.10399","title":"Medication toxicity among patients with ankylosing spondylitis","display_name":"Medication toxicity among patients with ankylosing spondylitis","publication_year":2002,"publication_date":"2002-06-05","ids":{"openalex":"https://openalex.org/W2014778338","doi":"https://doi.org/10.1002/art.10399","mag":"2014778338","pmid":"https://pubmed.ncbi.nlm.nih.gov/12115151"},"language":"en","primary_location":{"id":"doi:10.1002/art.10399","doi":"https://doi.org/10.1002/art.10399","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10399","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care & Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052860753","display_name":"Michael M. Ward","orcid":"https://orcid.org/0000-0003-1857-9367","observed_orcids":["https://orcid.org/0000-0003-1857-9367"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Ward","raw_affiliation_strings":["Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94034, USA. mward@leland.stanford.edu","Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94034, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94034, USA. mward@leland.stanford.edu","institution_ids":["https://openalex.org/I204866599"]},{"raw_affiliation_string":"Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94034, USA","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075674684","display_name":"Susana Kuzis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susana Kuzis","raw_affiliation_strings":["Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":1.1466,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77595201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"47","issue":"3","first_page":"234","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.871999979019165},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.8579999804496765},{"id":"https://openalex.org/keywords/nsaid-adverse-effects","display_name":"NSAID adverse effects","score":0.8240000009536743},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.853844940662384},{"id":"https://openalex.org/C2778139025","wikidata":"https://www.wikidata.org/wiki/Q408676","display_name":"Piroxicam","level":3,"score":0.8167096376419067},{"id":"https://openalex.org/C2779826273","wikidata":"https://www.wikidata.org/wiki/Q244408","display_name":"Diclofenac","level":2,"score":0.8067681789398193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7947854399681091},{"id":"https://openalex.org/C2778115740","wikidata":"https://www.wikidata.org/wiki/Q1215575","display_name":"Naproxen","level":3,"score":0.7665150761604309},{"id":"https://openalex.org/C2779383735","wikidata":"https://www.wikidata.org/wiki/Q420035","display_name":"Sulfasalazine","level":4,"score":0.7582666873931885},{"id":"https://openalex.org/C2777456732","wikidata":"https://www.wikidata.org/wiki/Q425207","display_name":"Nabumetone","level":3,"score":0.7525961399078369},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6742982864379883},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.6338151693344116},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.5752490162849426},{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.4711667001247406},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.4345386326313019},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40934738516807556},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4071163237094879},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34752240777015686},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.15547889471054077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010352","descriptor_name":"Patient Dropouts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012460","descriptor_name":"Sulfasalazine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/art.10399","doi":"https://doi.org/10.1002/art.10399","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.10399","pdf_url":null,"source":{"id":"https://openalex.org/S13698240","display_name":"Arthritis Care & Research","issn_l":"0893-7524","issn":["0893-7524","1529-0123","2151-464X","2151-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Care & Research","raw_type":"journal-article"},{"id":"pmid:12115151","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12115151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W36159642","https://openalex.org/W84416910","https://openalex.org/W117022523","https://openalex.org/W1601557292","https://openalex.org/W1965212418","https://openalex.org/W1974887827","https://openalex.org/W1979377048","https://openalex.org/W1982548911","https://openalex.org/W2024550067","https://openalex.org/W2035612894","https://openalex.org/W2054883739","https://openalex.org/W2079393974","https://openalex.org/W2099126630","https://openalex.org/W2111167308","https://openalex.org/W2158883488","https://openalex.org/W2160041723","https://openalex.org/W2402241442","https://openalex.org/W2404273758","https://openalex.org/W2412177641","https://openalex.org/W2417158427","https://openalex.org/W2418105589"],"related_works":["https://openalex.org/W1990043465","https://openalex.org/W2417158427","https://openalex.org/W1601557292","https://openalex.org/W2552371494","https://openalex.org/W2334872320","https://openalex.org/W2390409334","https://openalex.org/W4402069245","https://openalex.org/W2530352485","https://openalex.org/W2418103313","https://openalex.org/W2321762674"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,9,23,41,67,135,153,175],"role":[4],"of":[5,11,25,34,43,51,54,77,119,134,143,155,233,235],"medication":[6,220],"toxicity":[7,24,181,209,221],"in":[8,128],"discontinuation":[10,170,178,193,234],"antirheumatic":[12,236],"treatment":[13,44,75,122,156],"among":[14,200,224],"patients":[15,36,225],"with":[16,37,212,215,226],"ankylosing":[17],"spondylitis":[18],"(AS),":[19],"and":[20,45,63,140,174,187],"to":[21,48,131,148,168,177,180,191,208],"compare":[22],"different":[26],"medications.":[27],"METHODS:":[28],"In":[29],"a":[30,73,117],"prospective":[31],"longitudinal":[32],"study":[33],"241":[35,68],"AS,":[38,227],"we":[39],"examined":[40],"duration":[42,154],"discontinuations":[46,206],"due":[47,147,179,207],"side":[49],"effects":[50,125],"new":[52,74,121],"courses":[53,144],"sulfasalazine,":[55],"methotrexate,":[56],"ibuprofen,":[57],"naproxen,":[58],"indomethacin,":[59],"diclofenac,":[60],"piroxicam,":[61],"nabumetone,":[62],"celecoxib.":[64],"RESULTS:":[65],"Of":[66],"patients,":[69],"167":[70],"reported":[71,127],"having":[72],"course":[76],"either":[78],"sulfasalazine":[79,186],"(n":[80,84,88,92,96,100,104,108,113],"=":[81,85,89,93,97,101,105,109,114],"49),":[82],"methotrexate":[83],"19),":[86],"ibuprofen":[87],"105),":[90],"naproxen":[91],"57),":[94],"indomethacin":[95],"50),":[98],"diclofenac":[99],"38),":[102],"piroxicam":[103,213],"34),":[106],"nabumetone":[107],"27),":[110],"or":[111],"celecoxib":[112],"25),":[115],"for":[116,171,194],"total":[118],"404":[120],"courses.":[123,136],"Side":[124],"were":[126,145],"6.7%":[129],"(ibuprofen)":[130,139],"47.3%":[132],"(methotrexate)":[133],"Between":[137],"2%":[138],"23.5%":[141],"(piroxicam)":[142],"discontinued":[146],"toxicity.":[149,165],"For":[150],"each":[151],"medication,":[152],"was":[157],"most":[158],"often":[159],"limited":[160],"by":[161],"factors":[162],"other":[163,216],"than":[164,214],"The":[166,189],"time":[167,176,190],"drug":[169,192],"any":[172,195],"reason":[173,196],"did":[182,197],"not":[183,198],"differ":[184,199],"between":[185],"methotrexate.":[188],"nonsteroidal":[201],"antiinflammatory":[202],"drugs":[203],"(NSAIDs),":[204],"but":[205],"occurred":[210],"earlier":[211],"NSAIDs.":[217],"CONCLUSION:":[218],"Although":[219],"is":[222,229],"common":[223],"it":[228],"an":[230],"uncommon":[231],"cause":[232],"treatment.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}