{"id":"https://openalex.org/W2014771072","doi":"https://doi.org/10.1073/pnas.89.7.3040","title":"Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.","display_name":"Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2014771072","doi":"https://doi.org/10.1073/pnas.89.7.3040","mag":"2014771072","pmid":"https://pubmed.ncbi.nlm.nih.gov/1557410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/48799"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.89.7.3040","doi":"https://doi.org/10.1073/pnas.89.7.3040","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.7.3040","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/48799","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100679371","display_name":"Ning Guo","orcid":"https://orcid.org/0000-0001-5319-8442","observed_orcids":["https://orcid.org/0000-0001-5319-8442"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N H Guo","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051433481","display_name":"Henry C. Krutzsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H C Krutzsch","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","Meharry Medical College, Nashville, TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Meharry Medical College, Nashville, TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055075199","display_name":"E N\u00e8gre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E N\u00e8gre","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","Meharry Medical College, Nashville, TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Meharry Medical College, Nashville, TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043504060","display_name":"Thomas Vogel","orcid":"https://orcid.org/0000-0003-0205-3205","observed_orcids":["https://orcid.org/0000-0003-0205-3205"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Vogel","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","Meharry Medical College, Nashville, TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Meharry Medical College, Nashville, TN 37208","institution_ids":["https://openalex.org/I118073183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023072035","display_name":"Diane A. Blake","orcid":"https://orcid.org/0000-0002-7532-1541","observed_orcids":["https://orcid.org/0000-0002-7532-1541"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Blake","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031078822","display_name":"David D. Roberts","orcid":"https://orcid.org/0000-0002-2481-2981","observed_orcids":["https://orcid.org/0000-0002-2481-2981"]},"institutions":[{"id":"https://openalex.org/I118073183","display_name":"Meharry Medical College","ror":"https://ror.org/00k63dq23","country_code":"US","type":"education","lineage":["https://openalex.org/I118073183"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D D Roberts","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","Meharry Medical College, Nashville, TN 37208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and tDepartment of Biochemistry,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Meharry Medical College, Nashville, TN 37208","institution_ids":["https://openalex.org/I118073183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9454,"has_fulltext":false,"cited_by_count":163,"citation_normalized_percentile":{"value":0.93897417,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"89","issue":"7","first_page":"3040","last_page":"3044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombospondin","display_name":"thrombospondin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/heparin-binding-peptide","display_name":"heparin-binding peptides","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sulfatide","display_name":"sulfatide","score":0.8069999814033508},{"id":"https://openalex.org/keywords/melanoma-cell-adhesion","display_name":"melanoma cell adhesion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tryptophan-residues","display_name":"tryptophan residues","score":0.7929999828338623},{"id":"https://openalex.org/keywords/laminin-binding","display_name":"laminin binding","score":0.6919999718666077},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sulfated-glycoconjugates","display_name":"sulfated glycoconjugates","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cell-adhesion-inhibitors","display_name":"cell adhesion inhibitors","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C167814343","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondin","level":4,"score":0.8565828800201416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6094106435775757},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.5126103758811951},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45391374826431274},{"id":"https://openalex.org/C2910422434","wikidata":"https://www.wikidata.org/wiki/Q419341","display_name":"Thrombospondins","level":5,"score":0.44976502656936646},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.42113447189331055},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.4156751036643982},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3771415948867798},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3364632725715637},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.23182764649391174},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21550950407981873},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08702009916305542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06124177575111389},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.055830538272857666}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013433","descriptor_name":"Sulfoglycosphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019699","descriptor_name":"Thrombospondins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.89.7.3040","doi":"https://doi.org/10.1073/pnas.89.7.3040","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.7.3040","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:48799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/48799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:1557410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1557410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:48799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/48799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1185392560","display_name":"IN VITRO MODEL OF CORNEAL WOUND HEALING: ROLE OF MATRIX","funder_award_id":"1r01ey009092-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2356707739","display_name":null,"funder_award_id":"R01 EY09092","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1523736322","https://openalex.org/W1526075888","https://openalex.org/W1534240923","https://openalex.org/W1540432147","https://openalex.org/W1568527001","https://openalex.org/W1585957774","https://openalex.org/W1586757551","https://openalex.org/W1598116581","https://openalex.org/W1599651650","https://openalex.org/W1950519844","https://openalex.org/W1964204236","https://openalex.org/W1974966622","https://openalex.org/W1993038327","https://openalex.org/W2000781965","https://openalex.org/W2021131210","https://openalex.org/W2046938785","https://openalex.org/W2050763556","https://openalex.org/W2064239932","https://openalex.org/W2070132182","https://openalex.org/W2074511156","https://openalex.org/W2077443612","https://openalex.org/W2092751827","https://openalex.org/W2096415735","https://openalex.org/W2096880046","https://openalex.org/W2100468028","https://openalex.org/W2120056767","https://openalex.org/W2130308633","https://openalex.org/W2150688416","https://openalex.org/W2167899389"],"related_works":["https://openalex.org/W1597493507","https://openalex.org/W1966771896","https://openalex.org/W2418751925","https://openalex.org/W1530782757","https://openalex.org/W1530045241","https://openalex.org/W2012496435","https://openalex.org/W1526532569","https://openalex.org/W1983956381","https://openalex.org/W2096415735","https://openalex.org/W2130308633"],"abstract_inverted_index":{"Peptides":[0],"from":[1,52],"the":[2,13,30,53,57,75,126,137,151],"three":[3],"type":[4,139,152],"I":[5,140,153],"repeats":[6],"of":[7,32,85,93,155,161],"human":[8,98],"endothelial":[9],"cell":[10,65,72],"thrombospondin,":[11,33],"containing":[12,56],"consensus":[14,109],"sequence-Trp-Ser-Xaa-Trp-,":[15],"bind":[16],"to":[17,38,74,97,144,148],"sulfated":[18],"glycoconjugates":[19],"including":[20],"heparin":[21,46,145],"and":[22,111],"sulfatide.":[23,149],"The":[24,41,87,101],"peptides":[25,43,51,77,88,103,123,154],"are":[26,129],"potent":[27],"inhibitors":[28],"for":[29,131],"binding":[31,92,143],"laminin,":[34],"or":[35,95],"apolipoprotein":[36],"E":[37],"these":[39],"ligands.":[40],"thrombospondin":[42,54,94,156],"that":[44,125],"inhibit":[45,90],"binding,":[47],"but":[48,146],"not":[49,114,147],"adjacent":[50],"sequence":[55],"previously":[58,106],"identified":[59,107],"adhesive":[60],"motif":[61],"Val-Thr-Cys-Gly,":[62],"promote":[63],"melanoma":[64,99],"adhesion":[66,73],"when":[67],"immobilized":[68,76],"on":[69],"plastic.":[70],"Melanoma":[71],"is":[78],"inhibited":[79],"by":[80],"soluble":[81],"recombinant":[82],"heparin-binding":[83,108,162],"fragment":[84],"thrombospondin.":[86],"also":[89],"heparin-dependent":[91],"laminin":[96],"cells.":[100],"active":[102],"lack":[104],"any":[105,116],"sequences":[110],"most":[112],"do":[113],"contain":[115],"basic":[117,134],"amino":[118],"acids.":[119],"Studies":[120],"with":[121],"homologous":[122],"showed":[124],"tryptophan":[127],"residues":[128,135],"required":[130],"binding.":[132],"Adjacent":[133],"in":[136],"second":[138],"repeat":[141],"enhance":[142],"Thus":[150],"define":[157],"a":[158],"distinct":[159],"class":[160],"peptides.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}