{"id":"https://openalex.org/W2014767762","doi":"https://doi.org/10.1016/j.ajpath.2012.02.021","title":"MEF2C Ablation in Endothelial Cells Reduces Retinal Vessel Loss and Suppresses Pathologic Retinal Neovascularization in Oxygen-Induced Retinopathy","display_name":"MEF2C Ablation in Endothelial Cells Reduces Retinal Vessel Loss and Suppresses Pathologic Retinal Neovascularization in Oxygen-Induced Retinopathy","publication_year":2012,"publication_date":"2012-04-19","ids":{"openalex":"https://openalex.org/W2014767762","doi":"https://doi.org/10.1016/j.ajpath.2012.02.021","mag":"2014767762","pmid":"https://pubmed.ncbi.nlm.nih.gov/22521302","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378855"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2012.02.021","doi":"https://doi.org/10.1016/j.ajpath.2012.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2012.02.021","pdf_url":"http://ajp.amjpathol.org/article/S0002944012002441/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ajp.amjpathol.org/article/S0002944012002441/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101880742","display_name":"Zhenhua Xu","orcid":"https://orcid.org/0000-0002-3415-0133","observed_orcids":["https://orcid.org/0000-0002-3415-0133"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhua Xu","raw_affiliation_strings":["Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101064876","display_name":"Junsong Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junsong Gong","raw_affiliation_strings":["Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011332805","display_name":"Debasish Maiti","orcid":"https://orcid.org/0000-0002-7228-2794","observed_orcids":["https://orcid.org/0000-0002-7228-2794"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debasish Maiti","raw_affiliation_strings":["Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079375788","display_name":"Linh Vong","orcid":"https://orcid.org/0000-0003-2446-2624","observed_orcids":["https://orcid.org/0000-0003-2446-2624"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linh Vong","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058133767","display_name":"Lijuan Wu","orcid":"https://orcid.org/0000-0002-5761-5140","observed_orcids":["https://orcid.org/0000-0002-5761-5140"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lijuan Wu","raw_affiliation_strings":["Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035410011","display_name":"John J. Schwarz","orcid":"https://orcid.org/0000-0002-8713-4778","observed_orcids":["https://orcid.org/0000-0002-8713-4778"]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Schwarz","raw_affiliation_strings":["Center for Cardiovascular Sciences, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Sciences, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I4405260259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016107456","display_name":"Elia J. Duh","orcid":"https://orcid.org/0000-0003-1917-373X","observed_orcids":["https://orcid.org/0000-0003-1917-373X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elia J. Duh","raw_affiliation_strings":["Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016107456"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":3.3794,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.91295111,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"180","issue":"6","first_page":"2548","last_page":"2560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12484","display_name":"Retinopathy of Prematurity Studies","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mef2c","display_name":"MEF2C","score":1.0},{"id":"https://openalex.org/keywords/oxygen-induced-retinopathy","display_name":"oxygen-induced retinopathy","score":0.890999972820282},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/retinal-angiogenesis","display_name":"retinal angiogenesis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/retinal-vascular-development","display_name":"retinal vascular development","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ischemic-retinopathy","display_name":"ischemic retinopathy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C51183755","wikidata":"https://www.wikidata.org/wiki/Q83166919","display_name":"Mef2","level":5,"score":0.7448118925094604},{"id":"https://openalex.org/C2779918416","wikidata":"https://www.wikidata.org/wiki/Q1423087","display_name":"Retinopathy of prematurity","level":4,"score":0.7357897758483887},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6872164607048035},{"id":"https://openalex.org/C146291010","wikidata":"https://www.wikidata.org/wiki/Q18029008","display_name":"MEF2C","level":4,"score":0.6735480427742004},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5873706936836243},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5163601636886597},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.47342684864997864},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.43796902894973755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4301048219203949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40471261739730835},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3521808981895447},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3041514754295349},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2558947503566742},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.16087624430656433},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.08946609497070312},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08005139231681824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.07181099057197571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012178","descriptor_name":"Retinopathy of Prematurity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012178","descriptor_name":"Retinopathy of Prematurity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015861","descriptor_name":"Retinal Neovascularization","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015861","descriptor_name":"Retinal Neovascularization","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015861","descriptor_name":"Retinal Neovascularization","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018006","descriptor_name":"Myogenic Regulatory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018006","descriptor_name":"Myogenic Regulatory Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018006","descriptor_name":"Myogenic Regulatory Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064326","descriptor_name":"MEF2 Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ajpath.2012.02.021","doi":"https://doi.org/10.1016/j.ajpath.2012.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2012.02.021","pdf_url":"http://ajp.amjpathol.org/article/S0002944012002441/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2665255","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378855","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3378855","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3378855","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:22521302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22521302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2012.02.021","doi":"https://doi.org/10.1016/j.ajpath.2012.02.021","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2012.02.021","pdf_url":"http://ajp.amjpathol.org/article/S0002944012002441/pdf","source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1686255064","display_name":null,"funder_award_id":"EY018138","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4047733740","display_name":"FUNCTIONS OF MEF2C IN VASCULAR DEVELOPMENT","funder_award_id":"R01HL060853","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6721138976","display_name":"Role and regulation of MEF2C in retinal angiogenesis","funder_award_id":"R01EY018138","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306172","display_name":"Juvenile Diabetes Research Foundation International","ror":"https://ror.org/00vqxjy61"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333181","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014767762.pdf","grobid_xml":"https://content.openalex.org/works/W2014767762.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W183432655","https://openalex.org/W1483128131","https://openalex.org/W1538850399","https://openalex.org/W1548659316","https://openalex.org/W1552787667","https://openalex.org/W1768274470","https://openalex.org/W1966632353","https://openalex.org/W1968690854","https://openalex.org/W1971977081","https://openalex.org/W1972638695","https://openalex.org/W1973197740","https://openalex.org/W1975855729","https://openalex.org/W1982831550","https://openalex.org/W1985856548","https://openalex.org/W1985907458","https://openalex.org/W1992714205","https://openalex.org/W1993307873","https://openalex.org/W1994014733","https://openalex.org/W1995139285","https://openalex.org/W2002047543","https://openalex.org/W2002744059","https://openalex.org/W2008813164","https://openalex.org/W2010363122","https://openalex.org/W2010835900","https://openalex.org/W2017517482","https://openalex.org/W2023257711","https://openalex.org/W2023404968","https://openalex.org/W2024200940","https://openalex.org/W2024599421","https://openalex.org/W2029114316","https://openalex.org/W2029274317","https://openalex.org/W2035140372","https://openalex.org/W2042704812","https://openalex.org/W2043389111","https://openalex.org/W2046146856","https://openalex.org/W2053098204","https://openalex.org/W2055217734","https://openalex.org/W2072808422","https://openalex.org/W2076975406","https://openalex.org/W2093234681","https://openalex.org/W2099020618","https://openalex.org/W2112384663","https://openalex.org/W2116631863","https://openalex.org/W2120505405","https://openalex.org/W2121699212","https://openalex.org/W2124920102","https://openalex.org/W2126493135","https://openalex.org/W2130527936","https://openalex.org/W2135238033","https://openalex.org/W2138968049","https://openalex.org/W2141816935","https://openalex.org/W2148743089","https://openalex.org/W2148908764","https://openalex.org/W2153522676","https://openalex.org/W2156271388","https://openalex.org/W2157288494","https://openalex.org/W2161322544","https://openalex.org/W4245106190","https://openalex.org/W6632870055"],"related_works":["https://openalex.org/W1035862803","https://openalex.org/W1156824253","https://openalex.org/W4405869388","https://openalex.org/W2570966546","https://openalex.org/W2155382351","https://openalex.org/W3005440078","https://openalex.org/W4414335829","https://openalex.org/W918527295","https://openalex.org/W4414427169","https://openalex.org/W4400280821"],"abstract_inverted_index":{"Ischemic":[0],"retinopathies,":[1],"including":[2,62],"retinopathy":[3,127],"of":[4,12,46,50,88,101,105,143,177,196,219],"prematurity":[5],"and":[6,20,84,96,128,147,164,174,187,217],"diabetic":[7],"retinopathy,":[8],"are":[9],"major":[10],"causes":[11],"blindness.":[13],"Both":[14],"have":[15,68],"two":[16],"phases,":[17],"vessel":[18,123],"loss":[19,124],"consequent":[21],"hypoxia-driven":[22],"pathologic":[23,144,223],"retinal":[24,91,114,135,145,155,200,212,224],"neovascularization,":[25],"yet":[26],"relatively":[27],"little":[28],"is":[29],"known":[30],"about":[31],"the":[32,47,63,74,86,172,193],"transcription":[33,51],"factors":[34,52],"regulating":[35],"these":[36],"processes.":[37],"Myocyte":[38],"enhancer":[39],"factor":[40],"2":[41],"(MEF2)":[42],"C,":[43],"a":[44,69,98,190],"member":[45],"MEF2":[48],"family":[49],"that":[53],"plays":[54],"an":[55,208],"important":[56],"role":[57,72,87,191,210],"in":[58,73,90,97,112,120,125,153,185,192,211],"multiple":[59],"developmental":[60],"programs,":[61],"cardiovascular":[64],"system,":[65],"seems":[66],"to":[67],"significant":[70],"functional":[71],"vasculature.":[75],"We,":[76],"therefore,":[77],"generated":[78],"endothelial":[79],"cell":[80],"(EC)-specific":[81],"MEF2C-deficient":[82],"mice":[83],"explored":[85],"MEF2C":[89,106,118,151,183,197,205,220],"vascularization":[92],"during":[93],"normal":[94,113],"development":[95],"mouse":[99],"model":[100],"oxygen-induced":[102,126],"retinopathy.":[103],"Ablation":[104],"did":[107],"not":[108],"cause":[109],"appreciable":[110],"defects":[111],"vascular":[115,131],"development.":[116],"However,":[117],"ablation":[119],"ECs":[121,156,161,213],"suppressed":[122],"strongly":[129],"promoted":[130],"regrowth,":[132],"consequently":[133],"reducing":[134],"avascularity.":[136],"This":[137],"finding":[138],"was":[139,180],"associated":[140],"with":[141],"suppression":[142],"angiogenesis":[146],"blood-retinal":[148],"barrier":[149],"dysfunction.":[150],"knockdown":[152,184,198],"cultured":[154],"using":[157],"small-interfering":[158],"RNAs":[159],"rescued":[160],"from":[162],"death":[163],"stimulated":[165],"tube":[166,202],"formation":[167],"under":[168,214],"stress":[169,215],"conditions,":[170,216],"confirming":[171],"endothelial-autonomous":[173],"antiangiogenic":[175,209],"roles":[176],"MEF2C.":[178],"HO-1":[179],"induced":[181],"by":[182],"vitro":[186],"may":[188,206,221],"play":[189,207],"proangiogenic":[194],"effect":[195],"on":[199],"EC":[201],"formation.":[203],"Thus,":[204],"modulation":[218],"prevent":[222],"neovascularization.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}