{"id":"https://openalex.org/W2014762236","doi":"https://doi.org/10.1186/1758-2652-11-s1-p237","title":"Frequency of functional drug disposition gene polymorphism in Thai population: relevance to antiretroviral drugs","display_name":"Frequency of functional drug disposition gene polymorphism in Thai population: relevance to antiretroviral drugs","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2014762236","doi":"https://doi.org/10.1186/1758-2652-11-s1-p237","mag":"2014762236"},"language":"en","primary_location":{"id":"doi:10.1186/1758-2652-11-s1-p237","doi":"https://doi.org/10.1186/1758-2652-11-s1-p237","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2652-11-s1-p237","pdf_url":"https://jiasociety.biomedcentral.com/counter/pdf/10.1186/1758-2652-11-S1-P237","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jiasociety.biomedcentral.com/counter/pdf/10.1186/1758-2652-11-S1-P237","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078285617","display_name":"Ammara Chaikan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Chaikan","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057473836","display_name":"Nitipatana Chierakul","orcid":"https://orcid.org/0000-0002-1663-6420","observed_orcids":["https://orcid.org/0000-0002-1663-6420"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"N Chierakul","raw_affiliation_strings":["Siriraj Hospital, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siriraj Hospital, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058369766","display_name":"Natpratou Saguenwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114375","display_name":"Bamrasnaradura Infectious Diseases Institute","ror":"https://ror.org/0200vq221","country_code":"TH","type":"company","lineage":["https://openalex.org/I4210114375"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"N Saguenwong","raw_affiliation_strings":["Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand","institution_ids":["https://openalex.org/I4210114375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045697889","display_name":"Charoen Chuchuttaworn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Chuchuttaworn","raw_affiliation_strings":["Central Chest Hospital, Nonthaburi, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Chest Hospital, Nonthaburi, Thailand","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066429649","display_name":"Andrew Owen","orcid":"https://orcid.org/0000-0002-9819-7651","observed_orcids":["https://orcid.org/0000-0002-9819-7651"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Owen","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067575028","display_name":"Laura Dickinson","orcid":"https://orcid.org/0000-0001-5557-9396","observed_orcids":["https://orcid.org/0000-0001-5557-9396"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L Dickinson","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185300","display_name":"SH Khoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"SH Khoo","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111488227","display_name":"DJ Back","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"DJ Back","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085271816","display_name":"Geraint Davies","orcid":"https://orcid.org/0000-0002-3819-490X","observed_orcids":["https://orcid.org/0000-0002-3819-490X"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"GR Davies","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"Suppl 1","first_page":"P237","last_page":"P237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/functional-polymorphisms","display_name":"functional polymorphisms","score":0.765999972820282},{"id":"https://openalex.org/keywords/antiretroviral-drugs","display_name":"antiretroviral drugs","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plasma-exposure","display_name":"plasma exposure","score":0.8389999866485596},{"id":"https://openalex.org/keywords/thai-population","display_name":"Thai population","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8765985369682312},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.5662815570831299},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5596376657485962},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5151306390762329},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45753175020217896},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.45320630073547363},{"id":"https://openalex.org/C38022665","wikidata":"https://www.wikidata.org/wiki/Q1149305","display_name":"Disposition","level":2,"score":0.43729591369628906},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43174540996551514},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3516060709953308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2928464412689209},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24880698323249817},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.19237688183784485},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17205485701560974},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0831940770149231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06917059421539307},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/1758-2652-11-s1-p237","doi":"https://doi.org/10.1186/1758-2652-11-s1-p237","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2652-11-s1-p237","pdf_url":"https://jiasociety.biomedcentral.com/counter/pdf/10.1186/1758-2652-11-S1-P237","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/1758-2652-11-s1-p237","doi":"https://doi.org/10.1186/1758-2652-11-s1-p237","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1758-2652-11-s1-p237","pdf_url":"https://jiasociety.biomedcentral.com/counter/pdf/10.1186/1758-2652-11-S1-P237","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014762236.pdf","grobid_xml":"https://content.openalex.org/works/W2014762236.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2945444375","https://openalex.org/W2518959531","https://openalex.org/W4391192402","https://openalex.org/W2260167533","https://openalex.org/W605383521","https://openalex.org/W154452522","https://openalex.org/W2168410565","https://openalex.org/W631245368","https://openalex.org/W7014490153","https://openalex.org/W3083922921"],"abstract_inverted_index":{"Purpose":[0],"of":[1,8,44,56,66],"the":[2,54],"study":[3,46],"Significantly":[4],"higher":[5],"plasma":[6,64],"exposure":[7],"some":[9],"protease":[10],"inhibitors":[11],"(PIs)":[12],"has":[13],"been":[14],"observed":[15],"in":[16,50,59],"Thai":[17,52],"subjects":[18],"compared":[19],"to":[20,48,62],"Caucasians.":[21],"These":[22],"differences":[23,38],"may":[24,39],"partially":[25],"be":[26],"explained":[27],"by":[28],"factors":[29],"such":[30],"as":[31],"body":[32],"weight":[33],"and":[34],"diet.":[35],"However,":[36],"pharmacogenetic":[37],"also":[40],"contribute.":[41],"The":[42],"aim":[43],"this":[45],"was":[47],"investigate,":[49],"a":[51],"population,":[53],"frequency":[55],"functional":[57],"polymorphisms":[58],"genes":[60],"known":[61],"influence":[63],"concentrations":[65],"antiretroviral":[67],"drugs.":[68]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
