{"id":"https://openalex.org/W2014734035","doi":"https://doi.org/10.1177/1073858408327805","title":"AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons","display_name":"AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons","publication_year":2009,"publication_date":"2009-04-09","ids":{"openalex":"https://openalex.org/W2014734035","doi":"https://doi.org/10.1177/1073858408327805","mag":"2014734035","pmid":"https://pubmed.ncbi.nlm.nih.gov/19359670"},"language":"en","primary_location":{"id":"doi:10.1177/1073858408327805","doi":"https://doi.org/10.1177/1073858408327805","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1073858408327805","pdf_url":null,"source":{"id":"https://openalex.org/S103928886","display_name":"The Neuroscientist","issn_l":"1073-8584","issn":["1073-8584","1089-4098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Neuroscientist","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033384682","display_name":"Milo\u0161 R. Spasi\u0107","orcid":"https://orcid.org/0000-0001-5451-7003","observed_orcids":["https://orcid.org/0000-0001-5451-7003"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Milo\u0161 R. Spasi\u0107","raw_affiliation_strings":["Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045606950","display_name":"Patrick Callaerts","orcid":"https://orcid.org/0000-0003-4530-4561","observed_orcids":["https://orcid.org/0000-0003-4530-4561"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patrick Callaerts","raw_affiliation_strings":["Laboratory of Developmental Genetics, Flanders Institute\rfor Biotechnology (VIB), Leuven, Belgium, Laboratory of Developmental Genetics, Department of\rHuman Genetics, K.U. Leuven, Leuven, Belgium","Laboratory of Developmental Genetics, Flanders Institute#R#for Biotechnology (VIB), Leuven, Belgium, Laboratory of Developmental Genetics, Department of#R#Human Genetics, K.U. Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Genetics, Flanders Institute\rfor Biotechnology (VIB), Leuven, Belgium, Laboratory of Developmental Genetics, Department of\rHuman Genetics, K.U. Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"]},{"raw_affiliation_string":"Laboratory of Developmental Genetics, Flanders Institute#R#for Biotechnology (VIB), Leuven, Belgium, Laboratory of Developmental Genetics, Department of#R#Human Genetics, K.U. Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076592063","display_name":"Koen Norga","orcid":"https://orcid.org/0000-0002-9231-0350","observed_orcids":["https://orcid.org/0000-0002-9231-0350"]},"institutions":[{"id":"https://openalex.org/I2802017950","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Koenraad K. Norga","raw_affiliation_strings":["Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, , Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium, , Pediatric Hematology and Oncology, Department of Woman & Child, K.U. Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076592063"],"corresponding_institution_ids":["https://openalex.org/I2802017950","https://openalex.org/I99464096"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.6263,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.5103321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"4","first_page":"309","last_page":"316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuronal-energy-metabolism","display_name":"neuronal energy metabolism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8109999895095825},{"id":"https://openalex.org/keywords/amp-atp-ratio","display_name":"AMP/ATP ratio","score":0.8450000286102295},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.796999990940094},{"id":"https://openalex.org/keywords/hypoxia-ischemia","display_name":"hypoxia-ischemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neuronal-activity","display_name":"neuronal activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.5950000286102295},{"id":"https://openalex.org/keywords/excitable-cells","display_name":"excitable cells","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9484683275222778},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.7418126463890076},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.6951481103897095},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6486358642578125},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6400331258773804},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212013125419617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5056397914886475},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4100208580493927},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4014909565448761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1490771770477295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12525537610054016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/1073858408327805","doi":"https://doi.org/10.1177/1073858408327805","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1073858408327805","pdf_url":null,"source":{"id":"https://openalex.org/S103928886","display_name":"The Neuroscientist","issn_l":"1073-8584","issn":["1073-8584","1089-4098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Neuroscientist","raw_type":"journal-article"},{"id":"pmid:19359670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19359670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320322837","display_name":"Vlaams Instituut voor Biotechnologie","ror":"https://ror.org/03xrhmk39"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1514229573","https://openalex.org/W1757356499","https://openalex.org/W1964495120","https://openalex.org/W1980316562","https://openalex.org/W1983844571","https://openalex.org/W1995341268","https://openalex.org/W2000468444","https://openalex.org/W2000801162","https://openalex.org/W2005329028","https://openalex.org/W2006707086","https://openalex.org/W2014899200","https://openalex.org/W2017219924","https://openalex.org/W2018389920","https://openalex.org/W2019574577","https://openalex.org/W2025765786","https://openalex.org/W2026535174","https://openalex.org/W2027042003","https://openalex.org/W2035825575","https://openalex.org/W2065185593","https://openalex.org/W2069474358","https://openalex.org/W2070224555","https://openalex.org/W2072633898","https://openalex.org/W2092395757","https://openalex.org/W2093172338","https://openalex.org/W2096361448","https://openalex.org/W2111553439","https://openalex.org/W2112133879","https://openalex.org/W2126722763","https://openalex.org/W2132757921","https://openalex.org/W2136748154","https://openalex.org/W2136980094","https://openalex.org/W2146235143","https://openalex.org/W2171507662"],"related_works":["https://openalex.org/W2168600054","https://openalex.org/W3191867406","https://openalex.org/W2006613070","https://openalex.org/W2005329028","https://openalex.org/W151349665","https://openalex.org/W2026535174","https://openalex.org/W2951104254","https://openalex.org/W2096361448","https://openalex.org/W1980895793","https://openalex.org/W2109552459"],"abstract_inverted_index":{"AMP-activated":[0],"protein":[1],"kinase":[2],"(AMPK)":[3],"constitutes":[4],"a":[5,31,44,147],"molecular":[6],"hub":[7],"for":[8,99],"cellular":[9,34,51],"metabolic":[10,47,128,166],"control,":[11],"common":[12],"to":[13,24,53,106],"all":[14],"eukaryotic":[15],"cells.":[16,67,172],"Numerous":[17],"reports":[18,110],"have":[19,96,115],"established":[20],"how":[21],"AMPK":[22,71,113,141],"responds":[23],"changes":[25],"in":[26,58,72,121,130,150,158,164],"the":[27,54,73,79,83,131,155,159,165],"AMP:ATP":[28],"ratio":[29],"as":[30,63,146],"measure":[32],"of":[33,46,70,78,133,161,170],"energy":[35,56,107],"levels.":[36],"In":[37],"this":[38],"way,":[39],"it":[40],"integrates":[41],"control":[42,167],"over":[43],"number":[45],"enzymes":[48],"and":[49,65,76,102,118,135,168],"adapts":[50],"processes":[52],"current":[55],"status":[57],"various":[59],"cell":[60],"types,":[61],"such":[62],"muscle":[64],"liver":[66],"The":[68],"role":[69,163],"development,":[74],"function,":[75],"maintenance":[77],"nervous":[80],"system,":[81],"on":[82,140],"other":[84],"hand,":[85],"has":[86],"only":[87],"recently":[88],"gained":[89],"attention.":[90],"Neurons,":[91],"while":[92],"highly":[93],"metabolically":[94],"active,":[95],"poor":[97],"capacity":[98],"nutrient":[100],"storage":[101],"are":[103],"thus":[104],"sensitive":[105],"fluctuations.":[108],"Recent":[109],"demonstrate":[111],"that":[112],"may":[114],"neuroprotective":[116],"properties":[117],"is":[119],"activated":[120],"neurons":[122],"by":[123,127],"resveratrol":[124],"but":[125],"also":[126,142],"stress":[129],"form":[132],"ischemia/hypoxia":[134],"glucose":[136],"deprivation.":[137],"Novel":[138],"studies":[139],"implicate":[143],"neuronal":[144],"activity":[145],"critical":[148],"factor":[149],"neurodegeneration.":[151],"Here":[152],"we":[153],"discuss":[154],"latest":[156],"advances":[157],"knowledge":[160],"AMPK's":[162],"survival":[169],"excitable":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
