{"id":"https://openalex.org/W2014730586","doi":"https://doi.org/10.1529/biophysj.107.125542","title":"The Mycobacterium tuberculosis Virulence Factor Trehalose Dimycolate Imparts Desiccation Resistance to Model Mycobacterial Membranes","display_name":"The Mycobacterium tuberculosis Virulence Factor Trehalose Dimycolate Imparts Desiccation Resistance to Model Mycobacterial Membranes","publication_year":2008,"publication_date":"2008-03-07","ids":{"openalex":"https://openalex.org/W2014730586","doi":"https://doi.org/10.1529/biophysj.107.125542","mag":"2014730586","pmid":"https://pubmed.ncbi.nlm.nih.gov/18326657","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2397374"},"language":"en","primary_location":{"id":"doi:10.1529/biophysj.107.125542","doi":"https://doi.org/10.1529/biophysj.107.125542","is_oa":true,"landing_page_url":"https://doi.org/10.1529/biophysj.107.125542","pdf_url":"http://www.cell.com/article/S0006349508703394/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349508703394/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061992994","display_name":"Christopher W. Harland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W. Harland","raw_affiliation_strings":["Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703, USA","Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703, USA","institution_ids":["https://openalex.org/I181233156"]},{"raw_affiliation_string":"Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084264502","display_name":"David Rabuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Rabuka","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409133","display_name":"Carolyn Ruth Bertozzi","orcid":"https://orcid.org/0000-0003-4482-2754","observed_orcids":["https://orcid.org/0000-0003-4482-2754"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn R. Bertozzi","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, California 94720","Department of Molecular and Cell Biology, University of California, Berkeley, California 94720","Howard Hughes Medical Institute, University of California, Berkeley, California 94720","Physical Bioscience and Materials Science Divisions, Lawrence Berkeley National Laboratory, Berkeley, California 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California, Berkeley, California 94720","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Physical Bioscience and Materials Science Divisions, Lawrence Berkeley National Laboratory, Berkeley, California 94720","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090734819","display_name":"R. Parthasarathy","orcid":"https://orcid.org/0000-0002-6006-4749","observed_orcids":["https://orcid.org/0000-0002-6006-4749"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raghuveer Parthasarathy","raw_affiliation_strings":["Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 94703","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090734819"],"corresponding_institution_ids":["https://openalex.org/I181233156"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.393,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.78813326,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"94","issue":"12","first_page":"4718","last_page":"4724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trehalose-dimycolate","display_name":"trehalose dimycolate","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/desiccation-resistance","display_name":"desiccation resistance","score":0.9350000023841858},{"id":"https://openalex.org/keywords/membrane-dehydration","display_name":"membrane dehydration","score":0.6430000066757202},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/membrane-glycolipids","display_name":"membrane glycolipids","score":0.8009999990463257},{"id":"https://openalex.org/keywords/membrane-integrity","display_name":"membrane integrity","score":0.3659999966621399},{"id":"https://openalex.org/keywords/cord-factor","display_name":"cord factor","score":0.3440000116825104}],"concepts":[{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.7527503967285156},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7138089537620544},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.707758903503418},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6679648160934448},{"id":"https://openalex.org/C2778452849","wikidata":"https://www.wikidata.org/wiki/Q421773","display_name":"Trehalose","level":2,"score":0.5847209692001343},{"id":"https://openalex.org/C50402729","wikidata":"https://www.wikidata.org/wiki/Q903071","display_name":"Desiccation","level":2,"score":0.5139719843864441},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.46711501479148865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37441158294677734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11535888910293579},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09642988443374634},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0845295786857605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.077556312084198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0719505250453949}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003311","descriptor_name":"Cord Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003890","descriptor_name":"Desiccation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1529/biophysj.107.125542","doi":"https://doi.org/10.1529/biophysj.107.125542","is_oa":true,"landing_page_url":"https://doi.org/10.1529/biophysj.107.125542","pdf_url":"http://www.cell.com/article/S0006349508703394/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2397374","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2397374","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophys J","raw_type":"Text"},{"id":"pmid:18326657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18326657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1529/biophysj.107.125542","doi":"https://doi.org/10.1529/biophysj.107.125542","is_oa":true,"landing_page_url":"https://doi.org/10.1529/biophysj.107.125542","pdf_url":"http://www.cell.com/article/S0006349508703394/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2414571338","display_name":"Dynamics of TB and MDR TB transmission in areas with high HIV prevalence","funder_award_id":"R01AI051622","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014730586.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W58360496","https://openalex.org/W65609038","https://openalex.org/W161223034","https://openalex.org/W378341119","https://openalex.org/W419562888","https://openalex.org/W1491721980","https://openalex.org/W1523183619","https://openalex.org/W1575388066","https://openalex.org/W1580619527","https://openalex.org/W1604441141","https://openalex.org/W1607296894","https://openalex.org/W1927858698","https://openalex.org/W1963925741","https://openalex.org/W1964817343","https://openalex.org/W1965894076","https://openalex.org/W1978201308","https://openalex.org/W1982843047","https://openalex.org/W1991104229","https://openalex.org/W1992463658","https://openalex.org/W2000370325","https://openalex.org/W2022488218","https://openalex.org/W2038066421","https://openalex.org/W2038346993","https://openalex.org/W2039653756","https://openalex.org/W2039696862","https://openalex.org/W2040036919","https://openalex.org/W2043064410","https://openalex.org/W2049821355","https://openalex.org/W2052367587","https://openalex.org/W2061534442","https://openalex.org/W2065903108","https://openalex.org/W2068576212","https://openalex.org/W2071637240","https://openalex.org/W2077822496","https://openalex.org/W2084559690","https://openalex.org/W2089623748","https://openalex.org/W2089972364","https://openalex.org/W2092627505","https://openalex.org/W2105570009","https://openalex.org/W2109287721","https://openalex.org/W2110829617","https://openalex.org/W2111444379","https://openalex.org/W2115781573","https://openalex.org/W2122195274","https://openalex.org/W2140981202","https://openalex.org/W2142447329","https://openalex.org/W2143016004","https://openalex.org/W2144010669","https://openalex.org/W2144760559","https://openalex.org/W2156350829","https://openalex.org/W2157737997","https://openalex.org/W2158023121","https://openalex.org/W2158802325","https://openalex.org/W2199354360","https://openalex.org/W2415275225","https://openalex.org/W2990891832","https://openalex.org/W4244798503","https://openalex.org/W6770627776"],"related_works":["https://openalex.org/W2006427775","https://openalex.org/W1994593926","https://openalex.org/W2017359927","https://openalex.org/W3032622706","https://openalex.org/W2577815567","https://openalex.org/W4398172535","https://openalex.org/W2917639779","https://openalex.org/W1999439840","https://openalex.org/W3021872983","https://openalex.org/W1991955034"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}