{"id":"https://openalex.org/W2014705877","doi":"https://doi.org/10.1523/jneurosci.5672-12.2013","title":"Ambient Temperature Affects the Temperature Threshold for TRPM8 Activation through Interaction of Phosphatidylinositol 4,5-Bisphosphate","display_name":"Ambient Temperature Affects the Temperature Threshold for TRPM8 Activation through Interaction of Phosphatidylinositol 4,5-Bisphosphate","publication_year":2013,"publication_date":"2013-04-03","ids":{"openalex":"https://openalex.org/W2014705877","doi":"https://doi.org/10.1523/jneurosci.5672-12.2013","mag":"2014705877","pmid":"https://pubmed.ncbi.nlm.nih.gov/23554496","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6618937"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.5672-12.2013","doi":"https://doi.org/10.1523/jneurosci.5672-12.2013","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5672-12.2013","pdf_url":"https://www.jneurosci.org/content/jneuro/33/14/6154.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/33/14/6154.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108643884","display_name":"Fumitaka Fujita","orcid":"https://orcid.org/0009-0000-1982-8826","observed_orcids":["https://orcid.org/0009-0000-1982-8826"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]},{"id":"https://openalex.org/I4405265512","display_name":"Mandom Corp. (Japan)","ror":"https://ror.org/0517pdh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265512"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumitaka Fujita","raw_affiliation_strings":["Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan. fujita-f@mandom.co.jp","1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","2Central Research Laboratories, Mandom Corporation, Osaka 540-8530, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan. fujita-f@mandom.co.jp","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"2Central Research Laboratories, Mandom Corporation, Osaka 540-8530, Japan,","institution_ids":["https://openalex.org/I4405265512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110709145","display_name":"Kunitoshi Uchida","orcid":"https://orcid.org/0009-0007-7537-791X","observed_orcids":["https://orcid.org/0009-0007-7537-791X"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunitoshi Uchida","raw_affiliation_strings":["1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","3National Institute for Physiological Sciences, Okazaki 444-8585, Japan, and","4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"3National Institute for Physiological Sciences, Okazaki 444-8585, Japan, and","institution_ids":["https://openalex.org/I4210145863"]},{"raw_affiliation_string":"4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan","institution_ids":["https://openalex.org/I200475212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029195277","display_name":"Masayuki Takaishi","orcid":"https://orcid.org/0009-0000-3191-0603","observed_orcids":["https://orcid.org/0009-0000-3191-0603"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]},{"id":"https://openalex.org/I4405265512","display_name":"Mandom Corp. (Japan)","ror":"https://ror.org/0517pdh87","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265512"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Takaishi","raw_affiliation_strings":["1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","2Central Research Laboratories, Mandom Corporation, Osaka 540-8530, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"2Central Research Laboratories, Mandom Corporation, Osaka 540-8530, Japan,","institution_ids":["https://openalex.org/I4405265512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030676954","display_name":"Takaaki Sokabe","orcid":"https://orcid.org/0000-0003-1280-9424","observed_orcids":["https://orcid.org/0000-0003-1280-9424"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Sokabe","raw_affiliation_strings":["1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan","institution_ids":["https://openalex.org/I200475212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074653699","display_name":"Makoto Tominaga","orcid":"https://orcid.org/0000-0003-3111-3772","observed_orcids":["https://orcid.org/0000-0003-3111-3772"]},"institutions":[{"id":"https://openalex.org/I199525922","display_name":"National Institutes of Natural Sciences","ror":"https://ror.org/055n47h92","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922"]},{"id":"https://openalex.org/I200475212","display_name":"The Graduate University for Advanced Studies, SOKENDAI","ror":"https://ror.org/0516ah480","country_code":"JP","type":"education","lineage":["https://openalex.org/I200475212"]},{"id":"https://openalex.org/I4210097088","display_name":"Okazaki Institute for Integrative Bioscience","ror":"https://ror.org/00v3cq569","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210097088"]},{"id":"https://openalex.org/I4210145863","display_name":"National Institute for Physiological Sciences","ror":"https://ror.org/048v13307","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1319490839","https://openalex.org/I199525922","https://openalex.org/I4210145863"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Tominaga","raw_affiliation_strings":["1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","3National Institute for Physiological Sciences, Okazaki 444-8585, Japan, and","4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan,","institution_ids":["https://openalex.org/I199525922","https://openalex.org/I4210097088"]},{"raw_affiliation_string":"3National Institute for Physiological Sciences, Okazaki 444-8585, Japan, and","institution_ids":["https://openalex.org/I4210145863"]},{"raw_affiliation_string":"4Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki 444-8585, Japan","institution_ids":["https://openalex.org/I200475212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7483,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.93910035,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"33","issue":"14","first_page":"6154","last_page":"6159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpm8","display_name":"TRPM8","score":1.0},{"id":"https://openalex.org/keywords/cold-sensing","display_name":"cold sensing","score":0.5249999761581421},{"id":"https://openalex.org/keywords/ambient-temperature","display_name":"ambient temperature","score":0.8989999890327454},{"id":"https://openalex.org/keywords/temperature-thresholds","display_name":"temperature thresholds","score":0.8399999737739563},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thermosensitive-trp-channels","display_name":"thermosensitive TRP channels","score":0.7570000290870667},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.972000002861023},{"id":"https://openalex.org/keywords/cold-sensation","display_name":"cold sensation","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C163146387","wikidata":"https://www.wikidata.org/wiki/Q15324395","display_name":"TRPM8","level":5,"score":0.8654347062110901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6579810976982117},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.6475595235824585},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6136727929115295},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.441045880317688},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.301612913608551},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2578198313713074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15141654014587402},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.11832138895988464},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.10119375586509705}],"mesh":[{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013697","descriptor_name":"Thermosensing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013697","descriptor_name":"Thermosensing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050053","descriptor_name":"TRPM Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.5672-12.2013","doi":"https://doi.org/10.1523/jneurosci.5672-12.2013","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5672-12.2013","pdf_url":"https://www.jneurosci.org/content/jneuro/33/14/6154.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:23554496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23554496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6618937","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6618937/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.5672-12.2013","doi":"https://doi.org/10.1523/jneurosci.5672-12.2013","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.5672-12.2013","pdf_url":"https://www.jneurosci.org/content/jneuro/33/14/6154.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014705877.pdf","grobid_xml":"https://content.openalex.org/works/W2014705877.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1511198581","https://openalex.org/W1942930266","https://openalex.org/W1974422045","https://openalex.org/W1981328110","https://openalex.org/W1995330222","https://openalex.org/W1995705528","https://openalex.org/W2022293360","https://openalex.org/W2026648897","https://openalex.org/W2033620602","https://openalex.org/W2038079237","https://openalex.org/W2041322673","https://openalex.org/W2043088091","https://openalex.org/W2043206871","https://openalex.org/W2044173336","https://openalex.org/W2051613742","https://openalex.org/W2062428853","https://openalex.org/W2066063983","https://openalex.org/W2071414239","https://openalex.org/W2085790118","https://openalex.org/W2088669151","https://openalex.org/W2089221377","https://openalex.org/W2090617423","https://openalex.org/W2107057154","https://openalex.org/W2111730001","https://openalex.org/W2113839545","https://openalex.org/W2118141613","https://openalex.org/W2123505183","https://openalex.org/W2138083852","https://openalex.org/W2143730803","https://openalex.org/W2156783552","https://openalex.org/W2171575119","https://openalex.org/W2172087567"],"related_works":["https://openalex.org/W2172087567","https://openalex.org/W2962590710","https://openalex.org/W4393186939","https://openalex.org/W2089298563","https://openalex.org/W4211137873","https://openalex.org/W3007418549","https://openalex.org/W2023966260","https://openalex.org/W4319916491","https://openalex.org/W2088669151","https://openalex.org/W2085790118"],"abstract_inverted_index":{"Cold":[0],"sensation":[1],"is":[2,12,56],"an":[3,44],"important":[4],"and":[5,10,123,131],"fundamental":[6],"sense":[7],"for":[8,119,199],"animals":[9],"it":[11],"known":[13],"to":[14,68,78,174],"be":[15,79,97],"affected":[16,57],"by":[17,58,81,185],"ambient":[18,62,84,93,113,157,186,192],"temperature.":[19,158,187],"Transient":[20],"Receptor":[21],"Potential":[22],"Melastatin":[23],"8":[24],"(TRPM8),":[25],"a":[26,32,40,127],"nonselective":[27],"cation":[28],"channel":[29],"expressed":[30],"in":[31,83,91,126,134,149,156,167,179],"subset":[33],"of":[34,47,54,88,102,105,121,142,171,204],"peripheral":[35],"afferent":[36],"fibers,":[37],"acts":[38],"as":[39],"cold":[41,51,73,132,151,181],"sensor,":[42],"having":[43],"activation":[45,120,201],"threshold":[46,53,75,118,153,183,198],"\u223c28\u00b0C.":[48],"Although":[49],"the":[50,72,86,100,116,140,150,168,180,196],"temperature":[52,63,74,89,114,117,152,182,193,197],"TRPM8":[55,125,172,200],"menthol":[59],"or":[60],"pH,":[61],"has":[64],"not":[65,96],"been":[66],"reported":[67],"affect":[69,195],"it.":[70],"Because":[71],"was":[76],"thought":[77],"unchanged":[80],"alterations":[82,155],"temperature,":[85],"relativity":[87],"sensing":[90],"different":[92],"temperatures":[94],"could":[95],"understood":[98],"at":[99,164],"level":[101,141],"molecular":[103],"function":[104],"thermosensitive":[106],"TRP":[107],"channels.":[108],"Here,":[109],"we":[110],"show":[111],"that":[112,191],"changed":[115],"human":[122],"rat":[124],"heterologous":[128],"expression":[129],"system":[130],"responses":[133],"mouse":[135],"DRG":[136],"neurons.":[137],"Moreover,":[138],"reducing":[139],"cellular":[143],"phosphatidylinositol":[144],"4,5-bisphosphate":[145],"(PIP2)":[146],"attenuated":[147,177],"changes":[148,178],"after":[154],"A":[159],"single":[160],"amino":[161],"acid":[162],"mutation":[163],"position":[165],"1008":[166],"C":[169],"terminus":[170],"(arginine":[173],"glutamine)":[175],"also":[176],"induced":[184],"These":[188],"findings":[189],"suggest":[190],"does":[194],"through":[202],"interaction":[203],"PIP2.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
