{"id":"https://openalex.org/W2014683164","doi":"https://doi.org/10.1097/wnf.0b013e318067e255","title":"Epigenetic Therapeutic Strategies for the Treatment of Neuropsychiatric Disorders","display_name":"Epigenetic Therapeutic Strategies for the Treatment of Neuropsychiatric Disorders","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2014683164","doi":"https://doi.org/10.1097/wnf.0b013e318067e255","mag":"2014683164","pmid":"https://pubmed.ncbi.nlm.nih.gov/18382183"},"language":"en","primary_location":{"id":"doi:10.1097/wnf.0b013e318067e255","doi":"https://doi.org/10.1097/wnf.0b013e318067e255","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e318067e255","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047021203","display_name":"Stephen I. Deutsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210154891","display_name":"Washington DC VA Medical Center","ror":"https://ror.org/050fz5z96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111569","https://openalex.org/I4210154891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen I. Deutsch","raw_affiliation_strings":["Mental Health Service Line (116A), Department of Veterans Affairs Medical Center, Washington, DC 20422, USA. Stephen.Deutsch@med.va.gov","Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Service Line (116A), Department of Veterans Affairs Medical Center, Washington, DC 20422, USA. Stephen.Deutsch@med.va.gov","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210154891"]},{"raw_affiliation_string":"Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048409402","display_name":"Richard B. Rosse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Rosse","raw_affiliation_strings":["Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014062802","display_name":"John P. Mastropaolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Mastropaolo","raw_affiliation_strings":["Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000428036","display_name":"Katrice D. Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katrice D. Long","raw_affiliation_strings":["Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037776902","display_name":"Brooke L. Gaskins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke L. Gaskins","raw_affiliation_strings":["Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Service Line (116A), Department of Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"raw_affiliation_string":"and Department of Psychiatry, Georgetown University School of Medicine, Washington, DC","institution_ids":["https://openalex.org/I184565670"]},{"raw_affiliation_string":"Center","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047021203"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210154891"],"apc_list":null,"apc_paid":null,"fwci":2.7396,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90378146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"2","first_page":"104","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.9100000262260437},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9490000009536743},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neuropsychiatric-disorders","display_name":"neuropsychiatric disorders","score":0.9240000247955322},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/polyglutamine-repeat","display_name":"polyglutamine repeat","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.859000027179718},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.972000002861023},{"id":"https://openalex.org/keywords/epigenetic-drugs","display_name":"epigenetic drugs","score":0.5519999861717224},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8645704984664917},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.6767162680625916},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6717591285705566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6497092843055725},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6251936554908752},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5788211226463318},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.4590406119823456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3811988830566406},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.31346040964126587},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.286443829536438},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26202741265296936}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/wnf.0b013e318067e255","doi":"https://doi.org/10.1097/wnf.0b013e318067e255","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wnf.0b013e318067e255","pdf_url":null,"source":{"id":"https://openalex.org/S3349026","display_name":"Clinical Neuropharmacology","issn_l":"0362-5664","issn":["0362-5664","1537-162X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Neuropharmacology","raw_type":"journal-article"},{"id":"pmid:18382183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18382183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1523349613","https://openalex.org/W1643390591","https://openalex.org/W1964372470","https://openalex.org/W1971334707","https://openalex.org/W1977383752","https://openalex.org/W1987105053","https://openalex.org/W1995049733","https://openalex.org/W2003902715","https://openalex.org/W2004181810","https://openalex.org/W2045182347","https://openalex.org/W2046459630","https://openalex.org/W2053689957","https://openalex.org/W2061481020","https://openalex.org/W2062740397","https://openalex.org/W2094277055","https://openalex.org/W2096949620","https://openalex.org/W2103405252","https://openalex.org/W2105180380","https://openalex.org/W2121264285","https://openalex.org/W2130685024","https://openalex.org/W2133131387","https://openalex.org/W2144291844","https://openalex.org/W2146840535","https://openalex.org/W2162140549","https://openalex.org/W2167905519","https://openalex.org/W2168942809","https://openalex.org/W2952410637"],"related_works":["https://openalex.org/W2164848159","https://openalex.org/W2514034491","https://openalex.org/W2024481840","https://openalex.org/W7037962546","https://openalex.org/W3157737865","https://openalex.org/W7167624716","https://openalex.org/W106049078","https://openalex.org/W119450353","https://openalex.org/W2519224509","https://openalex.org/W7117409363"],"abstract_inverted_index":{"Chromatin":[0,69],"remodeling":[1,70],"is":[2],"recognized":[3],"as":[4,75,84,158],"a":[5,76,137],"major":[6,105],"regulator":[7],"of":[8,17,27,43,46,52,65,94,100,140,153,160,175,185],"gene":[9],"expression":[10,93],"that":[11,20],"can":[12],"be":[13,73,111,118],"influenced":[14],"by":[15,92],"inhibition":[16],"epigenetic":[18,115,154,189],"mechanisms":[19],"result":[21],"in":[22,40,79,121,145,167],"stable,":[23],"heritable,":[24],"covalent":[25,36,133],"modifications":[26,37,134],"histone":[28,161],"proteins":[29,96,176],"and":[30,48,62,87,104,125,127,181,195,201,206,211],"their":[31,56],"associated":[32],"DNA.":[33],"Epigenetically":[34],"regulated":[35],"are":[38],"implicated":[39],"the":[41,142,146],"pathogenesis":[42],"some":[44],"forms":[45],"cancer":[47],"stimulated":[49],"clinical":[50],"trials":[51],"compounds":[53],"selected":[54],"for":[55],"ability":[57],"to":[58,131],"arrest":[59],"cell":[60,123,207],"division":[61],"promote":[63],"differentiation":[64],"malignantly":[66],"transformed":[67],"cells.":[68],"may":[71,117],"also":[72],"considered":[74],"therapeutic":[77,155,190],"target":[78],"diverse":[80],"neuropsychiatric":[81,186],"disorders":[82,90],"such":[83,157],"Huntington":[85],"disease":[86],"other":[88,182],"neurodegenerative":[89],"characterized":[91],"mutant":[95,171],"with":[97,177],"expanded":[98,178],"tracts":[99],"polyglutamine":[101,179],"repeats,":[102],"schizophrenia,":[103],"depression.":[106],"Ideally,":[107],"these":[108],"strategies":[109],"will":[110,198],"relatively":[112],"selective":[113],"because":[114],"abnormalities":[116],"most":[119],"pronounced":[120],"specific":[122],"types,":[124],"tissues":[126],"transcriptional":[128],"dysregulation":[129],"due":[130],"pathological":[132],"involve":[135],"only":[136],"small":[138],"percentage":[139],"all":[141],"expressed":[143],"genes":[144],"human":[147,172],"genome.":[148],"To":[149],"date,":[150],"beneficial":[151],"effects":[152],"interventions":[156],"administration":[159],"deacetylase":[162],"inhibitors":[163],"have":[164],"been":[165],"observed":[166],"transgenic":[168],"mice":[169],"expressing":[170],"DNA":[173],"constructs":[174],"repeats":[180],"rodent":[183],"models":[184],"disorders.":[187],"The":[188],"strategy":[191],"has":[192],"much":[193],"promise,":[194],"its":[196],"development":[197],"foster":[199],"collaboration":[200],"cross":[202],"fertilization":[203],"between":[204],"molecular":[205],"biologists,":[208],"oncologists,":[209],"psychiatrists,":[210],"neurologists.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
