{"id":"https://openalex.org/W2014667379","doi":"https://doi.org/10.1007/s11033-014-3350-z","title":"Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals","display_name":"Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals","publication_year":2014,"publication_date":"2014-04-02","ids":{"openalex":"https://openalex.org/W2014667379","doi":"https://doi.org/10.1007/s11033-014-3350-z","mag":"2014667379","pmid":"https://pubmed.ncbi.nlm.nih.gov/24695999"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-014-3350-z","doi":"https://doi.org/10.1007/s11033-014-3350-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-014-3350-z","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019347315","display_name":"Ling Jiang","orcid":"https://orcid.org/0000-0001-6702-9535","observed_orcids":["https://orcid.org/0000-0001-6702-9535","https://orcid.org/0009-0006-6176-6327"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Jiang","raw_affiliation_strings":["Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People's Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008863850","display_name":"Hong Weng","orcid":"https://orcid.org/0000-0001-7795-5671","observed_orcids":["https://orcid.org/0000-0001-7795-5671"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]},{"id":"https://openalex.org/I4405280586","display_name":"Institute of Medicine and Nursing, Hubei University of Medicine","ror":"https://ror.org/034rpft41","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405280586"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Weng","raw_affiliation_strings":["Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","Institute of Medicine and Nursing, Hubei University of Medicine, 30 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Institute of Medicine and Nursing, Hubei University of Medicine, 30 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4405280586"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming-Yue Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Yue Chen","raw_affiliation_strings":["Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038013079","display_name":"Chao Zhang","orcid":"https://orcid.org/0000-0002-9891-0605","observed_orcids":["https://orcid.org/0000-0002-9891-0605","https://orcid.org/0009-0004-0673-0482"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Zhang","raw_affiliation_strings":["Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048324094","display_name":"Xian\u2010Tao Zeng","orcid":"https://orcid.org/0000-0003-1262-725X","observed_orcids":["https://orcid.org/0000-0003-1262-725X"]},"institutions":[{"id":"https://openalex.org/I1285929390","display_name":"Hubei University of Medicine","ror":"https://ror.org/01dr2b756","country_code":"CN","type":"education","lineage":["https://openalex.org/I1285929390"]},{"id":"https://openalex.org/I4210117378","display_name":"Taihe Hospital","ror":"https://ror.org/02ftdsn70","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117378"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xian-Tao Zeng","raw_affiliation_strings":["Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]},{"raw_affiliation_string":"Department of Stomatology, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, Hubei Province, People\u2019s Republic of China","institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048324094"],"corresponding_institution_ids":["https://openalex.org/I1285929390","https://openalex.org/I4210117378"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.5821,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"7","first_page":"4795","last_page":"4801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cox-2-gene-polymorphisms","display_name":"COX-2 gene polymorphisms","score":0.9869999885559082},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.8650000095367432},{"id":"https://openalex.org/keywords/asian-populations","display_name":"Asian populations","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.774241030216217},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.7110203504562378},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6465513110160828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6379993557929993},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6366750001907349},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.605012834072113},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5566952228546143},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5446944832801819},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.4693606495857239},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4547145366668701},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.4330441951751709},{"id":"https://openalex.org/C2778883934","wikidata":"https://www.wikidata.org/wiki/Q4692285","display_name":"Aggressive periodontitis","level":3,"score":0.428778737783432},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4283711910247803},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.415336936712265},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3431411683559418},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2683534622192383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23946049809455872},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22920987010002136},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11228638887405396},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07025977969169617},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-014-3350-z","doi":"https://doi.org/10.1007/s11033-014-3350-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-014-3350-z","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:24695999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24695999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9969000220298767,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W191918886","https://openalex.org/W1552019767","https://openalex.org/W1555278976","https://openalex.org/W1920274084","https://openalex.org/W1973141232","https://openalex.org/W1979423827","https://openalex.org/W1992564329","https://openalex.org/W1992960211","https://openalex.org/W2007096057","https://openalex.org/W2009722907","https://openalex.org/W2010679694","https://openalex.org/W2034730781","https://openalex.org/W2047031525","https://openalex.org/W2049070802","https://openalex.org/W2049219648","https://openalex.org/W2050497411","https://openalex.org/W2060847638","https://openalex.org/W2070692790","https://openalex.org/W2072917488","https://openalex.org/W2077735384","https://openalex.org/W2092414718","https://openalex.org/W2095607085","https://openalex.org/W2107328434","https://openalex.org/W2117276919","https://openalex.org/W2132663528","https://openalex.org/W2136156766","https://openalex.org/W2139178640","https://openalex.org/W2146247834","https://openalex.org/W2152986337","https://openalex.org/W2153287976","https://openalex.org/W2165667039","https://openalex.org/W2168341956","https://openalex.org/W2412787647","https://openalex.org/W2500125083","https://openalex.org/W2612891587","https://openalex.org/W2762658637"],"related_works":["https://openalex.org/W2796537755","https://openalex.org/W3113833512","https://openalex.org/W1989264772","https://openalex.org/W1552019767","https://openalex.org/W4412929519","https://openalex.org/W2146247834","https://openalex.org/W2095607085","https://openalex.org/W3021717862","https://openalex.org/W2139178640","https://openalex.org/W2279030782"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
