{"id":"https://openalex.org/W2014649183","doi":"https://doi.org/10.1016/j.molimm.2007.02.005","title":"Enhanced binding affinity for Fc\u03b3RIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity","display_name":"Enhanced binding affinity for Fc\u03b3RIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity","publication_year":2007,"publication_date":"2007-03-27","ids":{"openalex":"https://openalex.org/W2014649183","doi":"https://doi.org/10.1016/j.molimm.2007.02.005","mag":"2014649183","pmid":"https://pubmed.ncbi.nlm.nih.gov/17379311"},"language":"en","primary_location":{"id":"doi:10.1016/j.molimm.2007.02.005","doi":"https://doi.org/10.1016/j.molimm.2007.02.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2007.02.005","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112765505","display_name":"Kazuhiro Masuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuhiro Masuda","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-Machi, Machida-Shi, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-Machi, Machida-Shi, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046832425","display_name":"Tsuguo Kubota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsuguo Kubota","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032819067","display_name":"Etsuji Kaneko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Etsuji Kaneko","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shigeru Iida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeru Iida","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070323911","display_name":"Masako Wakitani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masako Wakitani","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067404406","display_name":"Yukari Kobayashi-Natsume","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukari Kobayashi-Natsume","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077601858","display_name":"Ai Kubota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ai Kubota","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109957616","display_name":"Kenya Shitara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenya Shitara","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072708202","display_name":"Kazuyasu Nakamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kazuyasu Nakamura","raw_affiliation_strings":["Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, BioFrontier Laboratories, Kyowa HakkoKogyo Co., Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072708202"],"corresponding_institution_ids":[],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":null,"fwci":3.2333,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.92758263,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"44","issue":"12","first_page":"3122","last_page":"3131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fcgammariiia","display_name":"Fc\u03b3RIIIa","score":0.9399999976158142},{"id":"https://openalex.org/keywords/n-glycans","display_name":"N-glycans","score":0.7820000052452087},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.7450000047683716},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.8069999814033508},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/antibody-effector-functions","display_name":"antibody effector functions","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.9879385828971863},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.8112444281578064},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.7532125115394592},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7503212690353394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5647552013397217},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.539421558380127},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5377656817436218},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4532982409000397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3452753722667694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2966705858707428},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.22895842790603638},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1881089210510254},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1677798628807068},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08831781148910522}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005643","descriptor_name":"Fucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008722","descriptor_name":"Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.molimm.2007.02.005","doi":"https://doi.org/10.1016/j.molimm.2007.02.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molimm.2007.02.005","pdf_url":null,"source":{"id":"https://openalex.org/S92126311","display_name":"Molecular Immunology","issn_l":"0161-5890","issn":["0161-5890","1872-9142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Immunology","raw_type":"journal-article"},{"id":"pmid:17379311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17379311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W33733012","https://openalex.org/W60759546","https://openalex.org/W1484092314","https://openalex.org/W1485730287","https://openalex.org/W1529809181","https://openalex.org/W1534963014","https://openalex.org/W1571451553","https://openalex.org/W1595328377","https://openalex.org/W1914229355","https://openalex.org/W1964944723","https://openalex.org/W1965962344","https://openalex.org/W1972242350","https://openalex.org/W1976652440","https://openalex.org/W1979336667","https://openalex.org/W2018795884","https://openalex.org/W2040426470","https://openalex.org/W2044360617","https://openalex.org/W2044538137","https://openalex.org/W2051645590","https://openalex.org/W2057796652","https://openalex.org/W2059347528","https://openalex.org/W2063792914","https://openalex.org/W2068635250","https://openalex.org/W2073445298","https://openalex.org/W2079579628","https://openalex.org/W2079756029","https://openalex.org/W2081867678","https://openalex.org/W2084136419","https://openalex.org/W2094445987","https://openalex.org/W2107426197","https://openalex.org/W2109502548","https://openalex.org/W2111262648","https://openalex.org/W2115571948","https://openalex.org/W2126923540","https://openalex.org/W2128402413","https://openalex.org/W2137354517","https://openalex.org/W2143562636","https://openalex.org/W2156750419","https://openalex.org/W2160798258","https://openalex.org/W2168648203","https://openalex.org/W2281381316","https://openalex.org/W4250688128","https://openalex.org/W4294605288"],"related_works":["https://openalex.org/W2042105881","https://openalex.org/W2078353854","https://openalex.org/W1973073597","https://openalex.org/W2160798258","https://openalex.org/W2973611704","https://openalex.org/W2607033547","https://openalex.org/W2531610726","https://openalex.org/W2156471177","https://openalex.org/W2122208441","https://openalex.org/W7096669726"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}