{"id":"https://openalex.org/W2014585682","doi":"https://doi.org/10.1016/s0891-5849(03)00105-9","title":"Zinc-induced apoptosis in substantia nigra of rat brain: neuroprotection by vitamin D3","display_name":"Zinc-induced apoptosis in substantia nigra of rat brain: neuroprotection by vitamin D3","publication_year":2003,"publication_date":"2003-05-19","ids":{"openalex":"https://openalex.org/W2014585682","doi":"https://doi.org/10.1016/s0891-5849(03)00105-9","mag":"2014585682","pmid":"https://pubmed.ncbi.nlm.nih.gov/12757852"},"language":"en","primary_location":{"id":"doi:10.1016/s0891-5849(03)00105-9","doi":"https://doi.org/10.1016/s0891-5849(03)00105-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0891-5849(03)00105-9","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051999245","display_name":"Anya Maan\u2010Yuh Lin","orcid":"https://orcid.org/0000-0002-6203-5183","observed_orcids":["https://orcid.org/0000-0002-6203-5183"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Anya M.Y. Lin","raw_affiliation_strings":["Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","Department of Physiology, National Yang-Ming University, Taipei, Taiwan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Physiology, National Yang-Ming University, Taipei, Taiwan;","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034226809","display_name":"Su\u2010Feng Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"S.F. Fan","raw_affiliation_strings":["Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","Department of Physiology, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Physiology, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004393843","display_name":"De\u2010Ming Yang","orcid":"https://orcid.org/0000-0002-6923-4855","observed_orcids":["https://orcid.org/0000-0002-6923-4855"]},"institutions":[{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"D.M. Yang","raw_affiliation_strings":["Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","Department of Physiology, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Department of Physiology, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110150245","display_name":"L. L. Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"L.L. Hsu","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","Department of Physiology, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Department of Physiology, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]},{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.H.J. Yang","raw_affiliation_strings":["Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","Department of Physiology, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Department of Physiology, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051999245"],"corresponding_institution_ids":["https://openalex.org/I2803004286","https://openalex.org/I4387156312"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":3.2293,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.91176025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"11","first_page":"1416","last_page":"1425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.1842000037431717,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-neurotoxicity","display_name":"zinc neurotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.972000002861023},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7820000052452087},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.828000009059906},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.7590000033378601},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.8809999823570251},{"id":"https://openalex.org/keywords/striatal-dopamine","display_name":"striatal dopamine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/zinc-translocation","display_name":"zinc translocation","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9467901587486267},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6209592819213867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5970851182937622},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5889422297477722},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5676405429840088},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4746561646461487},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4516925811767578},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.44546759128570557},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3925180733203888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25678178668022156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1659778356552124},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.08321979641914368}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0891-5849(03)00105-9","doi":"https://doi.org/10.1016/s0891-5849(03)00105-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0891-5849(03)00105-9","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:12757852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12757852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W89358359","https://openalex.org/W127852528","https://openalex.org/W1691996697","https://openalex.org/W1766190906","https://openalex.org/W1817392531","https://openalex.org/W1969280474","https://openalex.org/W1972614641","https://openalex.org/W1979460016","https://openalex.org/W1981553614","https://openalex.org/W1983095071","https://openalex.org/W1984515541","https://openalex.org/W1985613988","https://openalex.org/W1989965028","https://openalex.org/W1991647860","https://openalex.org/W1992661805","https://openalex.org/W1993097538","https://openalex.org/W2002166614","https://openalex.org/W2004007082","https://openalex.org/W2012766958","https://openalex.org/W2018759588","https://openalex.org/W2021690131","https://openalex.org/W2023677185","https://openalex.org/W2026039965","https://openalex.org/W2033751142","https://openalex.org/W2040297593","https://openalex.org/W2042717034","https://openalex.org/W2052963114","https://openalex.org/W2054566340","https://openalex.org/W2057520074","https://openalex.org/W2061077435","https://openalex.org/W2063960864","https://openalex.org/W2067526555","https://openalex.org/W2068267504","https://openalex.org/W2070079020","https://openalex.org/W2072476822","https://openalex.org/W2078376971","https://openalex.org/W2080068413","https://openalex.org/W2107941015","https://openalex.org/W2118295710","https://openalex.org/W2130694557","https://openalex.org/W2133451731","https://openalex.org/W2141360605","https://openalex.org/W2162778581","https://openalex.org/W2167736576","https://openalex.org/W2170901098","https://openalex.org/W2172010179","https://openalex.org/W2401602310","https://openalex.org/W4302791540","https://openalex.org/W6603642136","https://openalex.org/W6684796217"],"related_works":["https://openalex.org/W1983095071","https://openalex.org/W2008418991","https://openalex.org/W1964891568","https://openalex.org/W2032676903","https://openalex.org/W1863689565","https://openalex.org/W2896170519","https://openalex.org/W2137385714","https://openalex.org/W3025212875","https://openalex.org/W4312114689","https://openalex.org/W2052963114"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}