{"id":"https://openalex.org/W2014566849","doi":"https://doi.org/10.1038/sj.bjc.6605981","title":"BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma","display_name":"BH3-only protein Bik is involved in both apoptosis induction and sensitivity to oxidative stress in multiple myeloma","publication_year":2010,"publication_date":"2010-11-09","ids":{"openalex":"https://openalex.org/W2014566849","doi":"https://doi.org/10.1038/sj.bjc.6605981","mag":"2014566849","pmid":"https://pubmed.ncbi.nlm.nih.gov/21063407","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3008608"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6605981","doi":"https://doi.org/10.1038/sj.bjc.6605981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605981","pdf_url":"https://www.nature.com/articles/6605981.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6605981.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111656324","display_name":"Linda Bodet","orcid":"https://orcid.org/0000-0002-8997-8173","observed_orcids":["https://orcid.org/0000-0002-8997-8173"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Bodet","raw_affiliation_strings":["Institut de Recherche Th\u00e9rapeutique de l'Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes BP70721 F-44007, France","Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l'Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Th\u00e9rapeutique de l'Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes BP70721 F-44007, France","institution_ids":[]},{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l'Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056403958","display_name":"Emmanuelle M\u00e9noret","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E M\u00e9noret","raw_affiliation_strings":["Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021522769","display_name":"G\u00e9raldine Descamps","orcid":"https://orcid.org/0009-0007-3933-1834","observed_orcids":["https://orcid.org/0009-0007-3933-1834"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G Descamps","raw_affiliation_strings":["Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051471778","display_name":"Catherine Pellat\u2010Deceunynck","orcid":"https://orcid.org/0000-0002-6287-8148","observed_orcids":["https://orcid.org/0000-0002-6287-8148"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Pellat-Deceunynck","raw_affiliation_strings":["Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108077657","display_name":"R\u00e9gis Bataille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Bataille","raw_affiliation_strings":["Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016122215","display_name":"Steven Le Gouill","orcid":"https://orcid.org/0000-0001-9840-2128","observed_orcids":["https://orcid.org/0000-0001-9840-2128"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Le Gouill","raw_affiliation_strings":["CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France","Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France","institution_ids":["https://openalex.org/I3019204325"]},{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103143602","display_name":"Philippe Moreau","orcid":"https://orcid.org/0000-0003-1780-8746","observed_orcids":["https://orcid.org/0000-0003-1780-8746"]},"institutions":[{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Moreau","raw_affiliation_strings":["CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France","institution_ids":["https://openalex.org/I3019204325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003041443","display_name":"Martine Amiot","orcid":"https://orcid.org/0000-0003-0428-7355","observed_orcids":["https://orcid.org/0000-0003-0428-7355"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Amiot","raw_affiliation_strings":["Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068580383","display_name":"Patricia Gomez\u2010Bougie","orcid":"https://orcid.org/0000-0002-4846-4782","observed_orcids":["https://orcid.org/0000-0002-4846-4782"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"P Gomez-Bougie","raw_affiliation_strings":["CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France","Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU de Nantes, Service d\u2019H\u00e9matologie Clinique, Nantes, F-44000, France","institution_ids":["https://openalex.org/I3019204325"]},{"raw_affiliation_string":"Inserm, UMR892, Institut de Recherche Th\u00e9rapeutique de l\u2019Universit\u00e9 de Nantes, Equipe 10 labellis\u00e9e Ligue Nationale contre le Cancer 2008, 8 quai Moncousu, Nantes, BP70721 F-44007, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068580383"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.7434,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.65129591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"103","issue":"12","first_page":"1808","last_page":"1814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bik","display_name":"BIK","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bh3-only-proteins","display_name":"BH3-only proteins","score":0.9139999747276306},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/building-information-modeling","display_name":"building information modeling","score":0.906000018119812},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bak","display_name":"Bak","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bh3-mimetics","display_name":"BH3 mimetics","score":0.902999997138977},{"id":"https://openalex.org/keywords/myeloma-cell-lines","display_name":"myeloma cell lines","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7048373222351074},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6170480251312256},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.6041101813316345},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5503066778182983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5273543000221252},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5138876438140869},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5121945738792419},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5080647468566895},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5034722685813904},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4882068932056427},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.4751731753349304},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45831841230392456},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4296506643295288},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41411933302879333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23711538314819336},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19226312637329102},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1327274739742279},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10795995593070984}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050976","descriptor_name":"Basic-Leucine Zipper Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/sj.bjc.6605981","doi":"https://doi.org/10.1038/sj.bjc.6605981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605981","pdf_url":"https://www.nature.com/articles/6605981.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2239202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3008608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21063407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21063407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3008608","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3008608/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6605981","doi":"https://doi.org/10.1038/sj.bjc.6605981","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6605981","pdf_url":"https://www.nature.com/articles/6605981.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014566849.pdf","grobid_xml":"https://content.openalex.org/works/W2014566849.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W35060329","https://openalex.org/W1524883877","https://openalex.org/W1815066161","https://openalex.org/W1816247929","https://openalex.org/W1976720365","https://openalex.org/W1976883744","https://openalex.org/W1978860891","https://openalex.org/W1997023504","https://openalex.org/W2009508186","https://openalex.org/W2032828747","https://openalex.org/W2037594780","https://openalex.org/W2053316324","https://openalex.org/W2053595706","https://openalex.org/W2059494778","https://openalex.org/W2071989867","https://openalex.org/W2078245424","https://openalex.org/W2088569476","https://openalex.org/W2091483784","https://openalex.org/W2103887016","https://openalex.org/W2113794558","https://openalex.org/W2116177527","https://openalex.org/W2137318638","https://openalex.org/W2145001317","https://openalex.org/W2155165473"],"related_works":["https://openalex.org/W2473836494","https://openalex.org/W415594369","https://openalex.org/W1980710014","https://openalex.org/W2547749949","https://openalex.org/W1638076008","https://openalex.org/W2582568343","https://openalex.org/W2979632660","https://openalex.org/W2807373913","https://openalex.org/W1962730730","https://openalex.org/W2320453976"],"abstract_inverted_index":{"BACKGROUND:":[0],"although":[1],"gene":[2],"expression":[3,56,77,93,111,153],"profile":[4],"of":[5,14,94,103,105],"multiple":[6],"myeloma":[7,27,41,48,136,189,203],"(MM)":[8],"patients":[9],"shows":[10],"a":[11,91,177],"wide":[12],"range":[13],"Bik/Nbk":[15],"expression,":[16],"varying":[17],"from":[18],"absent":[19],"to":[20,109,138,146,185],"high,":[21],"its":[22],"regulation":[23],"and":[24,45,60,70,107,126,156,167,183],"function":[25],"in":[26,37,100,179,188,202],"cells":[28,49,137,204],"is":[29],"poorly":[30],"understood.":[31],"Thus,":[32],"we":[33],"addressed":[34],"these":[35],"questions":[36],"MM.":[38],"METHODS:":[39],"human":[40],"cell":[42],"lines":[43],"(HMCLs)":[44],"primary":[46],"purified":[47],"were":[50],"studied":[51],"for":[52,198],"Bcl-2":[53,110,125],"family":[54],"protein":[55,96,122],"by":[57,80,87,124,131],"western":[58],"blot":[59],"further":[61,199],"correlation":[62],"analysis":[63],"was":[64,78,85,97],"performed.":[65],"Correlative":[66],"study":[67],"between":[68],"Bik":[69,95,116,133,142,151,175],"thyrotroph":[71],"embryonic":[72],"factor":[73,76],"(TEF)":[74],"transcription":[75],"analysed":[79,86],"PCR.":[81],"Stress":[82],"oxidative":[83,139,148,186],"response":[84],"flow":[88],"cytometry.":[89],"RESULTS:":[90],"strong":[92],"found":[98],"only":[99],"one":[101],"out":[102],"three":[104],"HMCL":[106],"correlated":[108],"(P=0.0006).":[112],"We":[113],"demonstrated":[114],"that":[115,163,174],"could":[117,164],"be":[118,196],"regulated":[119],"at":[120,127],"the":[121,128],"level":[123,130],"transcriptional":[129],"TEF.":[132],"overexpression":[134],"sensitises":[135],"stress":[140,187],"whereas":[141],"silencing":[143],"increases":[144],"resistance":[145],"H(2)O(2)":[147],"stress.":[149],"Furthermore,":[150],"ectopic":[152],"disrupts":[154],"Bim/Bcl-2":[155],"Bim/Bcl-xL":[157],"endogenous":[158,206],"complexes":[159],"triggering":[160],"Bim":[161],"release":[162],"induce":[165],"Bax":[166],"Bak":[168],"activation.":[169],"CONCLUSIONS:":[170],"ours":[171],"results":[172],"suggest":[173],"has":[176],"role":[178],"both,":[180],"apoptosis":[181],"induction":[182],"sensitivity":[184],"cells.":[190],"Small":[191],"BH3":[192],"mimetic":[193],"molecules":[194],"should":[195],"considered":[197],"apoptosis-based":[200],"therapy":[201],"expressing":[205],"Bik/Bcl-2":[207],"complexes.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
