{"id":"https://openalex.org/W2014531469","doi":"https://doi.org/10.1007/bf00967706","title":"Desensitization of prostaglandin F2? receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes","display_name":"Desensitization of prostaglandin F2? receptor-mediated phosphoinositide hydrolysis in cultured rat astrocytes","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2014531469","doi":"https://doi.org/10.1007/bf00967706","mag":"2014531469","pmid":"https://pubmed.ncbi.nlm.nih.gov/8065525"},"language":"en","primary_location":{"id":"doi:10.1007/bf00967706","doi":"https://doi.org/10.1007/bf00967706","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00967706","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113437087","display_name":"Masayuki Gotoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Gotoh","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Suita, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002020647","display_name":"Junichi Kitanaka","orcid":"https://orcid.org/0000-0001-9938-8508","observed_orcids":["https://orcid.org/0000-0001-9938-8508"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun-ichi Kitanaka","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yoshimi Hirasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimi Hirasawa","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103189267","display_name":"Kaoru Kondo","orcid":"https://orcid.org/0009-0008-7529-4791","observed_orcids":["https://orcid.org/0009-0008-7529-4791"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Kondo","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":null,"display_name":"Akemichi Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akemichi Baba","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":0.5308,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.5741681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"6","first_page":"679","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-f2alpha-receptor","display_name":"prostaglandin F2alpha receptor","score":0.8980000019073486},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phosphoinositide-hydrolysis","display_name":"phosphoinositide hydrolysis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/phloretin","display_name":"phloretin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/protein-synthesis-inhibitors","display_name":"protein synthesis inhibitors","score":0.7360000014305115},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.9319379329681396},{"id":"https://openalex.org/C92759361","wikidata":"https://www.wikidata.org/wiki/Q5891436","display_name":"Homologous desensitization","level":4,"score":0.6493419408798218},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5517706871032715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.543104887008667},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5338652729988098},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5315601229667664},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5303046703338623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5197500586509705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5000109672546387},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3348049819469452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31428399682044983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25557494163513184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16048705577850342},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00967706","doi":"https://doi.org/10.1007/bf00967706","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00967706","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmid:8065525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8065525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1492933791","https://openalex.org/W1546944401","https://openalex.org/W1589354481","https://openalex.org/W1889236699","https://openalex.org/W1939198520","https://openalex.org/W1964174737","https://openalex.org/W1967101173","https://openalex.org/W1970151060","https://openalex.org/W1970429382","https://openalex.org/W1977041825","https://openalex.org/W1977275887","https://openalex.org/W1977377809","https://openalex.org/W1999269212","https://openalex.org/W2001692359","https://openalex.org/W2002228741","https://openalex.org/W2002950947","https://openalex.org/W2003420705","https://openalex.org/W2018218145","https://openalex.org/W2022607217","https://openalex.org/W2026326195","https://openalex.org/W2037951208","https://openalex.org/W2051990576","https://openalex.org/W2056402816","https://openalex.org/W2059994807","https://openalex.org/W2060673518","https://openalex.org/W2064225056","https://openalex.org/W2073925424","https://openalex.org/W2074275745","https://openalex.org/W2074857000","https://openalex.org/W2093619744","https://openalex.org/W2114918609","https://openalex.org/W2136823785","https://openalex.org/W2155344313","https://openalex.org/W2167859431","https://openalex.org/W2260078012","https://openalex.org/W2397747161","https://openalex.org/W2413483194","https://openalex.org/W2415293478","https://openalex.org/W4248634331"],"related_works":["https://openalex.org/W1977377809","https://openalex.org/W2064225056","https://openalex.org/W2004015795","https://openalex.org/W2404755326","https://openalex.org/W2395909081","https://openalex.org/W3105793488","https://openalex.org/W2093619744","https://openalex.org/W2071252462","https://openalex.org/W2127137494","https://openalex.org/W4232909242"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}