{"id":"https://openalex.org/W2014530502","doi":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","title":"Differential activation of ErbB receptors in the rat olfactory mucosa by transforming growth factor-? and epidermal growth factorin vivo","display_name":"Differential activation of ErbB receptors in the rat olfactory mucosa by transforming growth factor-? and epidermal growth factorin vivo","publication_year":1998,"publication_date":"1998-11-05","ids":{"openalex":"https://openalex.org/W2014530502","doi":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","mag":"2014530502","pmid":"https://pubmed.ncbi.nlm.nih.gov/9805267"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S68990794","display_name":"Journal of Neurobiology","issn_l":"0022-3034","issn":["0022-3034","1097-4695"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022177895","display_name":"Patrick I. Ezeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick I. Ezeh","raw_affiliation_strings":["Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA","Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112778438","display_name":"Albert I. Farbman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Albert I. Farbman","raw_affiliation_strings":["Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Physiology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112778438"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":1.6655,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.8443818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"2","first_page":"199","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.8560000061988831},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":1.0},{"id":"https://openalex.org/keywords/erbb-receptors","display_name":"ErbB receptors","score":0.8299999833106995},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/olfactory-epithelium","display_name":"olfactory epithelium","score":0.9660000205039978},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.906000018119812},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9509999752044678},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":1.0}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7034310698509216},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.7024531364440918},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.6301978826522827},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.5986589193344116},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.49468013644218445},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.4944934546947479},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4813462197780609},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4701381325721741},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4454612135887146},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.4449392259120941},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.44220009446144104},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.4335237741470337},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4105464816093445},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3966933786869049},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3642423152923584},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3523075580596924},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3468197286128998},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32959824800491333},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.312031090259552},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.24432286620140076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17265614867210388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08041435480117798}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009831","descriptor_name":"Olfactory Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020893","descriptor_name":"Receptor, ErbB-3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4695(19981105)37:2<199::aid-neu1>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S68990794","display_name":"Journal of Neurobiology","issn_l":"0022-3034","issn":["0022-3034","1097-4695"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurobiology","raw_type":"journal-article"},{"id":"pmid:9805267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9805267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurobiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2346750204","display_name":"Chemoreception:From molecules to networks","funder_award_id":"P01DC000347","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011982118","https://openalex.org/W4236769136","https://openalex.org/W2033574370","https://openalex.org/W2061355011","https://openalex.org/W2041233736","https://openalex.org/W2414742734","https://openalex.org/W2034244924","https://openalex.org/W2109824367","https://openalex.org/W2268098582","https://openalex.org/W1986335023"],"abstract_inverted_index":{"Transforming":[0],"growth":[1,6,16,127,235],"factor-alpha":[2],"(TGF-alpha)":[3],"and":[4,45,84,99,142,148,166,192,217],"epidermal":[5],"factor":[7,128],"(EGF)":[8],"are":[9,42,239],"members":[10,41],"of":[11,15,33,48,65,73,125,179,206,246],"the":[12,23,29,36,52,63,66,94,118,134,153,172,198,225,230,234,242],"EGF":[13,24,85,112,195],"family":[14],"factors.":[17],"They":[18],"have":[19,86],"a":[20,70,114,202,252],"common":[21],"receptor,":[22],"receptor.":[25],"This":[26],"belongs":[27],"to":[28,51,89,131,152,160,248],"tyrosine":[30,58,75],"kinase":[31,59,76,81],"group":[32],"receptors":[34,173],"called":[35],"ErbB":[37,154],"receptor":[38,53,67],"family.":[39],"Other":[40],"ErbB-2,":[43],"ErbB-3,":[44],"ErbB-4.":[46],"Binding":[47],"either":[49],"ligand":[50,211],"elicits":[54],"an":[55,213],"increase":[56],"in":[57,62,93,97,104,121,224,254,258],"activity,":[60],"resulting":[61],"autophosphorylation":[64],"followed":[68],"by":[69],"phosphorylation":[71],"cascade":[72],"other":[74],"substrates":[77],"including":[78],"mitogen-activated":[79],"protein":[80],"(MAPK).":[82],"TGF-alpha":[83,110,188,200,247],"been":[87],"shown":[88],"stimulate":[90],"cell":[91,102,256],"division":[92,103,257],"olfactory":[95,119,140,255],"epithelium":[96],"vitro":[98],"may":[100,250],"regulate":[101],"vivo.":[105,259],"To":[106],"investigate":[107],"whether":[108],"exogenous":[109],"or":[111],"has":[113],"functional":[115],"effect":[116,214],"on":[117,215],"mucosa":[120,141],"vivo,":[122],"12.5-50":[123],"micrograms":[124],"each":[126],"was":[129,181,201],"administered":[130],"rats":[132],"via":[133],"carotid":[135],"artery.":[136],"After":[137],"2":[138],"min,":[139],"liver":[143],"samples":[144],"were":[145,158,174,222],"collected,":[146],"homogenized,":[147],"immunoprecipitated":[149],"with":[150,241],"antibodies":[151],"receptors.":[155,219],"The":[156],"immunoprecipitates":[157],"subjected":[159],"sodium":[161],"dodecyl":[162],"sulfate-polyacrylamide":[163],"gel":[164],"electrophoresis":[165],"Western":[167],"immunoblotting.":[168],"Using":[169],"phosphotyrosine":[170],"antibody,":[171],"probed":[175],"for":[176],"phosphorylation.":[177],"Activation":[178],"MAPK":[180,185],"also":[182],"investigated":[183],"using":[184],"antibody.":[186],"Exogenous":[187],"activated":[189,196],"EGFR,":[190],"ErbB-2":[191],"MAPK,":[193],"whereas":[194],"only":[197],"EGFR.":[199],"more":[203],"potent":[204],"activator":[205],"EGFR":[207,249],"than":[208],"EGF.":[209],"Neither":[210],"had":[212],"ErbB-3":[216],"ErbB-4":[218],"These":[220,237],"effects":[221],"absent":[223],"control":[226],"animals":[227],"which":[228],"received":[229],"same":[231],"solution":[232],"without":[233],"factor.":[236],"results":[238],"consistent":[240],"notion":[243],"that":[244],"binding":[245],"play":[251],"role":[253]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
