{"id":"https://openalex.org/W2014530500","doi":"https://doi.org/10.1016/0005-2744(73)90055-7","title":"Model discrimination and nonlinear parameter estimation in the analysis of the mechanism of action of \u03b2-hydroxybutyrate dehydrogenase from Rhodopseudomon as spheroides","display_name":"Model discrimination and nonlinear parameter estimation in the analysis of the mechanism of action of \u03b2-hydroxybutyrate dehydrogenase from Rhodopseudomon as spheroides","publication_year":1973,"publication_date":"1973-09-01","ids":{"openalex":"https://openalex.org/W2014530500","doi":"https://doi.org/10.1016/0005-2744(73)90055-7","mag":"2014530500","pmid":"https://pubmed.ncbi.nlm.nih.gov/4356305"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2744(73)90055-7","doi":"https://doi.org/10.1016/0005-2744(73)90055-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2744(73)90055-7","pdf_url":null,"source":{"id":"https://openalex.org/S4394906700","display_name":"Biochimica et Biophysica Acta (BBA) - Enzymology","issn_l":"0924-1086","issn":["0924-1086","0005-2744"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016405661","display_name":"Robert E. Hurst","orcid":"https://orcid.org/0000-0003-0370-1817","observed_orcids":["https://orcid.org/0000-0003-0370-1817"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Hurst","raw_affiliation_strings":["Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085445679","display_name":"Alexandra L. Pincock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexandra Pincock","raw_affiliation_strings":["Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040481785","display_name":"Louis H. Broekhoven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Louis H. Broekhoven","raw_affiliation_strings":["Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Queen's University, and Queen's University Computing Centre, Kingston-Ontario Canada","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":null,"apc_paid":null,"fwci":1.5645,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81727977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":"321","issue":"1","first_page":"1","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13487","display_name":"Statistical and numerical algorithms","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13487","display_name":"Statistical and numerical algorithms","score":0.37869998812675476,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.12269999831914902,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-hydroxybutyrate-dehydrogenase","display_name":"beta-hydroxybutyrate dehydrogenase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rhodopseudomonas-spheroides","display_name":"Rhodopseudomonas spheroides","score":0.9890000224113464},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.734000027179718},{"id":"https://openalex.org/keywords/ordered-sequential-mechanism","display_name":"ordered sequential mechanism","score":0.7799999713897705},{"id":"https://openalex.org/keywords/feedback-inhibition","display_name":"product inhibition","score":0.9810000061988831},{"id":"https://openalex.org/keywords/model-discrimination","display_name":"model discrimination","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nonlinear-parameter-estimation","display_name":"nonlinear parameter estimation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/data-blocking","display_name":"data blocking","score":0.7409999966621399},{"id":"https://openalex.org/keywords/rate-constants","display_name":"rate constants","score":0.7319999933242798},{"id":"https://openalex.org/keywords/jacobian-transformation","display_name":"Jacobian transformation","score":0.75},{"id":"https://openalex.org/keywords/confidence-regions","display_name":"confidence regions","score":0.7739999890327454},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.8569999933242798},{"id":"https://openalex.org/keywords/analysis-of-variance","display_name":"analysis of variance","score":0.6970000267028809},{"id":"https://openalex.org/keywords/enzyme-mechanism-of-action","display_name":"enzyme mechanism of action","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C46889948","wikidata":"https://www.wikidata.org/wiki/Q2755024","display_name":"Nonlinear regression","level":3,"score":0.6847924590110779},{"id":"https://openalex.org/C200331156","wikidata":"https://www.wikidata.org/wiki/Q506041","display_name":"Jacobian matrix and determinant","level":2,"score":0.6301898956298828},{"id":"https://openalex.org/C93391505","wikidata":"https://www.wikidata.org/wiki/Q658700","display_name":"Reaction rate constant","level":3,"score":0.5826874375343323},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.5752294063568115},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.5111823678016663},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4754181504249573},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.4094993472099304},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4010583758354187},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.37875863909721375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3749181032180786},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.33073776960372925},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18957647681236267},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.14738133549690247},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.10111284255981445}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006884","descriptor_name":"Hydroxybutyrate Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006884","descriptor_name":"Hydroxybutyrate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012242","descriptor_name":"Rhodobacter sphaeroides","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2744(73)90055-7","doi":"https://doi.org/10.1016/0005-2744(73)90055-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2744(73)90055-7","pdf_url":null,"source":{"id":"https://openalex.org/S4394906700","display_name":"Biochimica et Biophysica Acta (BBA) - Enzymology","issn_l":"0924-1086","issn":["0924-1086","0005-2744"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Enzymology","raw_type":"journal-article"},{"id":"pmid:4356305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4356305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W62898540","https://openalex.org/W102364220","https://openalex.org/W1543819219","https://openalex.org/W1938716260","https://openalex.org/W2006610670","https://openalex.org/W2031470163","https://openalex.org/W2033466124","https://openalex.org/W2045535388","https://openalex.org/W2082147763","https://openalex.org/W2268163223","https://openalex.org/W2318277125","https://openalex.org/W2324981434","https://openalex.org/W4246090862"],"related_works":["https://openalex.org/W1011749614","https://openalex.org/W2051333317","https://openalex.org/W2109954873","https://openalex.org/W1964899903","https://openalex.org/W2057985991","https://openalex.org/W2134773640","https://openalex.org/W1975422142","https://openalex.org/W1965597272","https://openalex.org/W7214258753","https://openalex.org/W7171924848"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}