{"id":"https://openalex.org/W2014518225","doi":"https://doi.org/10.1099/0022-1317-50-2-447","title":"Induction of 43 Ketosteroid Synthesis by Interferon in Mouse Adrenal Tumour Cell Cultures","display_name":"Induction of 43 Ketosteroid Synthesis by Interferon in Mouse Adrenal Tumour Cell Cultures","publication_year":1980,"publication_date":"1980-10-01","ids":{"openalex":"https://openalex.org/W2014518225","doi":"https://doi.org/10.1099/0022-1317-50-2-447","mag":"2014518225","pmid":"https://pubmed.ncbi.nlm.nih.gov/6161994"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-50-2-447","doi":"https://doi.org/10.1099/0022-1317-50-2-447","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-50-2-447","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112042227","display_name":"Charles Chany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Chany","raw_affiliation_strings":["Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111898720","display_name":"Danielle Mathieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D. Mathieu","raw_affiliation_strings":["Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113885012","display_name":"Anne Gr\u00e9goire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Gregoire","raw_affiliation_strings":["Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute de Recherches Scientifiques sur le Cancer, C.N.R.S., B.P. 8 Villejuif, France","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":null,"apc_paid":null,"fwci":0.4701,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.59671832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"2","first_page":"447","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon","display_name":"interferon","score":0.996999979019165},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.703000009059906},{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cell-rounding","display_name":"cell rounding","score":0.8230000138282776},{"id":"https://openalex.org/keywords/steroid-synthesis","display_name":"steroid synthesis","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.8385224342346191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7748823165893555},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.7572213411331177},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6089188456535339},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.4713689088821411},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47033175826072693},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.441920667886734},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3783366084098816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1222236156463623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0683373510837555}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007372","descriptor_name":"Interferons","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007664","descriptor_name":"Ketosteroids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/0022-1317-50-2-447","doi":"https://doi.org/10.1099/0022-1317-50-2-447","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-50-2-447","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:6161994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6161994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2163808480","https://openalex.org/W7098151942","https://openalex.org/W1999562640","https://openalex.org/W2005542755","https://openalex.org/W1966188030","https://openalex.org/W2018636279","https://openalex.org/W1984631282","https://openalex.org/W2005280925","https://openalex.org/W2073153622","https://openalex.org/W2011709774"],"abstract_inverted_index":{"Interferon,":[0],"like":[1],"cholera":[2,41],"toxin,":[3],"induces":[4,31],"in":[5,67],"mouse":[6,26],"adrenal":[7],"YI":[8,44],"cells":[9,45],"the":[10],"production":[11,51],"of":[12,52,59],"delta":[13],"3(4)":[14],"ketosteroids.":[15],"In":[16,43],"parallel,":[17],"cyclic":[18],"AMP":[19],"(cAMP)":[20],"is":[21,54,61,71],"activated.":[22],"At":[23],"high":[24],"concentrations,":[25],"but":[27],"not":[28],"human":[29],"interferon":[30,66],"a":[32],"cell":[33],"rounding":[34],"effect,":[35],"similar":[36],"to":[37],"that":[38,58],"obtained":[39],"with":[40],"toxin.":[42],"transformed":[46],"by":[47,57],"simian":[48],"adenovirus":[49],"7,":[50],"cAMP":[53],"still":[55],"increased":[56],"steroids":[60],"blocked.":[62],"The":[63],"role":[64],"if":[65],"these":[68],"cellular":[69],"events":[70],"discussed.":[72]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}