{"id":"https://openalex.org/W2014508254","doi":"https://doi.org/10.1016/s0024-3205(02)01791-5","title":"Evidence for a deficient pancreatic \u03b2-cell response in a rat model of hyperthyroidism","display_name":"Evidence for a deficient pancreatic \u03b2-cell response in a rat model of hyperthyroidism","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2014508254","doi":"https://doi.org/10.1016/s0024-3205(02)01791-5","mag":"2014508254","pmid":"https://pubmed.ncbi.nlm.nih.gov/12088765"},"language":"en","primary_location":{"id":"doi:10.1016/s0024-3205(02)01791-5","doi":"https://doi.org/10.1016/s0024-3205(02)01791-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(02)01791-5","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mari Fukuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mari Fukuchi","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, 903-0215, Okinawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, 903-0215, Okinawa, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091249720","display_name":"Michio Shimabukuro","orcid":"https://orcid.org/0000-0001-7835-7665","observed_orcids":["https://orcid.org/0000-0001-7835-7665"]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Michio Shimabukuro","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038296246","display_name":"Yoshinori Shimajiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Shimajiri","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110191670","display_name":"Yoshito Oshiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshito Oshiro","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113139793","display_name":"Moritake Higa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moritake Higa","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109843834","display_name":"H. Akamine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Akamine","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039278029","display_name":"Ichiro Komiya","orcid":"https://orcid.org/0000-0002-4965-4561","observed_orcids":["https://orcid.org/0000-0002-4965-4561"]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Komiya","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056006041","display_name":"Nobuyuki Takasu","orcid":"https://orcid.org/0000-0002-2163-2758","observed_orcids":["https://orcid.org/0000-0002-2163-2758"]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Takasu","raw_affiliation_strings":["Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan","institution_ids":["https://openalex.org/I32915989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091249720"],"corresponding_institution_ids":["https://openalex.org/I32915989"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.7828,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.74065097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"9","first_page":"1059","last_page":"1070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9890000224113464},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5849999785423279},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7170000076293945},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.6439999938011169},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.917099118232727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.89838707447052},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7596416473388672},{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.6672971248626709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5143498182296753},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5097872614860535},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5029653906822205},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.45962560176849365},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4405999481678009},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.269003689289093},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10535171627998352},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0024-3205(02)01791-5","doi":"https://doi.org/10.1016/s0024-3205(02)01791-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0024-3205(02)01791-5","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:12088765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12088765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323155","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W28351195","https://openalex.org/W40321310","https://openalex.org/W1266211854","https://openalex.org/W1643947316","https://openalex.org/W1899450842","https://openalex.org/W1963751714","https://openalex.org/W1968634993","https://openalex.org/W1984608336","https://openalex.org/W1986770408","https://openalex.org/W1997473658","https://openalex.org/W2011196179","https://openalex.org/W2013456794","https://openalex.org/W2021741557","https://openalex.org/W2055326705","https://openalex.org/W2061199659","https://openalex.org/W2063720970","https://openalex.org/W2064159206","https://openalex.org/W2072031497","https://openalex.org/W2073751796","https://openalex.org/W2074950664","https://openalex.org/W2078073869","https://openalex.org/W2081795471","https://openalex.org/W2085596220","https://openalex.org/W2102078208","https://openalex.org/W2157822195","https://openalex.org/W2195437615","https://openalex.org/W2265224957","https://openalex.org/W3023173633","https://openalex.org/W4299949231"],"related_works":["https://openalex.org/W2314005993","https://openalex.org/W2154339787","https://openalex.org/W2011196179","https://openalex.org/W2585570182","https://openalex.org/W2022052281","https://openalex.org/W2318910420","https://openalex.org/W2000858364","https://openalex.org/W2993722724","https://openalex.org/W1965179614","https://openalex.org/W2062334532"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}