{"id":"https://openalex.org/W2014492708","doi":"https://doi.org/10.1083/jcb.143.7.1859","title":"Pex18p and Pex21p, a Novel Pair of Related Peroxins Essential for Peroxisomal Targeting by the PTS2 Pathway","display_name":"Pex18p and Pex21p, a Novel Pair of Related Peroxins Essential for Peroxisomal Targeting by the PTS2 Pathway","publication_year":1998,"publication_date":"1998-12-28","ids":{"openalex":"https://openalex.org/W2014492708","doi":"https://doi.org/10.1083/jcb.143.7.1859","mag":"2014492708","pmid":"https://pubmed.ncbi.nlm.nih.gov/9864360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2175223"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.143.7.1859","doi":"https://doi.org/10.1083/jcb.143.7.1859","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.143.7.1859","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175223/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003937344","display_name":"P. Edward Purdue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Edward Purdue","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089733388","display_name":"Xudong Yang","orcid":"https://orcid.org/0000-0001-8144-919X","observed_orcids":["https://orcid.org/0000-0001-8144-919X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xudong Yang","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059540441","display_name":"Paul B. Lazarow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul B. Lazarow","raw_affiliation_strings":["Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Anatomy, Mount Sinai School of Medicine, New York, New York 10029-6574","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089733388"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":2.2635,"has_fulltext":true,"cited_by_count":165,"citation_normalized_percentile":{"value":0.87084212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"143","issue":"7","first_page":"1859","last_page":"1869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.4496999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.4496999979019165,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.27559998631477356,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxins","display_name":"peroxins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/peroxisomal-targeting","display_name":"peroxisomal targeting","score":0.7269999980926514},{"id":"https://openalex.org/keywords/peroxisome-biogenesis","display_name":"peroxisome biogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/peroxisomal-matrix","display_name":"peroxisomal matrix","score":0.5929999947547913},{"id":"https://openalex.org/keywords/rhizomelic-chondrodysplasia-punctata","display_name":"rhizomelic chondrodysplasia punctata","score":0.9049999713897705},{"id":"https://openalex.org/keywords/functional-redundancy","display_name":"functional redundancy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.89394211769104},{"id":"https://openalex.org/C205668238","wikidata":"https://www.wikidata.org/wiki/Q7169502","display_name":"Peroxisomal targeting signal","level":4,"score":0.8836603164672852},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.8510934114456177},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.6452345252037048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5999491810798645},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.5507930517196655},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5052972435951233},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.41981634497642517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3605653643608093},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3222372531890869},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30218493938446045},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2715691030025482},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2591847777366638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21295183897018433},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074437","descriptor_name":"Peroxisomal Targeting Signal 2 Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000101","descriptor_name":"Acetyl-CoA C-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008830","descriptor_name":"Microbodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008830","descriptor_name":"Microbodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042962","descriptor_name":"Acyl-CoA Oxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.143.7.1859","doi":"https://doi.org/10.1083/jcb.143.7.1859","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.143.7.1859","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2175223","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175223/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175223/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:9864360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9864360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.6526","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.6526","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f3/12/J_Cell_Biol_1998_Dec_28_143(7)_1859-1869.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2175223","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175223/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175223/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3718164935","display_name":null,"funder_award_id":"DK19394","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014492708.pdf","grobid_xml":"https://content.openalex.org/works/W2014492708.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W119049379","https://openalex.org/W1492622409","https://openalex.org/W1526043578","https://openalex.org/W1529947122","https://openalex.org/W1559096719","https://openalex.org/W1579834701","https://openalex.org/W1668858601","https://openalex.org/W1903792504","https://openalex.org/W1932321778","https://openalex.org/W1964535884","https://openalex.org/W1987049546","https://openalex.org/W1989907564","https://openalex.org/W2006120283","https://openalex.org/W2011100117","https://openalex.org/W2016626029","https://openalex.org/W2017891724","https://openalex.org/W2018171395","https://openalex.org/W2025104020","https://openalex.org/W2027647762","https://openalex.org/W2029831255","https://openalex.org/W2029902521","https://openalex.org/W2047667305","https://openalex.org/W2049738765","https://openalex.org/W2065699737","https://openalex.org/W2069191162","https://openalex.org/W2073972553","https://openalex.org/W2076526497","https://openalex.org/W2082926317","https://openalex.org/W2097009167","https://openalex.org/W2109722045","https://openalex.org/W2114625295","https://openalex.org/W2115027228","https://openalex.org/W2115073295","https://openalex.org/W2131764652","https://openalex.org/W2132762612","https://openalex.org/W2136577266","https://openalex.org/W2142552197","https://openalex.org/W2152015543","https://openalex.org/W2157841878","https://openalex.org/W2169333620","https://openalex.org/W2170566884","https://openalex.org/W2413107236"],"related_works":["https://openalex.org/W2165823564","https://openalex.org/W1991436138","https://openalex.org/W1976257663","https://openalex.org/W2104042107","https://openalex.org/W2400424776","https://openalex.org/W2894792117","https://openalex.org/W2082926317","https://openalex.org/W4412759850","https://openalex.org/W2006605310","https://openalex.org/W2017891724"],"abstract_inverted_index":{"We":[0],"have":[1,87],"identified":[2],"ScPex18p":[3],"and":[4,47,109,118,140,148,153,160,168,185],"ScPex21p,":[5],"two":[6],"novel":[7],"S.":[8],"cerevisiae":[9],"peroxins":[10],"required":[11,182],"for":[12,183],"protein":[13,54],"targeting":[14,69,125,155],"via":[15],"the":[16,30,38,52,79,94,110,124],"PTS2":[17,34,39,72,154,186],"branch":[18],"of":[19,32,70,82,126],"peroxisomal":[20,73,95],"biogenesis.":[21],"Targeting":[22],"by":[23,67],"this":[24,83,114],"pathway":[25],"is":[26,43,156],"known":[27],"to":[28,128,165],"involve":[29],"interaction":[31],"oligopeptide":[33],"signals":[35],"with":[36,49,134],"Pex7p,":[37],"receptor.":[40,84],"Pex7p":[41,127,135,150,184],"function":[42,101],"conserved":[44],"between":[45],"yeasts":[46],"humans,":[48],"defects":[50],"in":[51,93,113,123,137,141],"human":[53],"causing":[55],"rhizomelic":[56],"chondrodysplasia":[57],"punctata":[58],"(RCDP),":[59],"a":[60,103,177],"severe,":[61],"lethal":[62],"peroxisome":[63],"biogenesis":[64],"disorder":[65],"characterized":[66],"aberrant":[68],"several":[71],"proteins,":[74],"but":[75],"uncertainty":[76],"remains":[77,151],"about":[78],"subcellular":[80],"localization":[81],"Previously,":[85],"we":[86],"reported":[88],"that":[89,98,174],"ScPex7p":[90],"resides":[91],"predominantly":[92],"matrix,":[96],"suggesting":[97],"it":[99],"may":[100],"as":[102,120],"highly":[104],"unusual":[105],"intraorganellar":[106],"import":[107],"receptor,":[108],"data":[111],"presented":[112],"paper":[115],"identify":[116],"Pex18p":[117,147,159],"Pex21p":[119,161],"key":[121],"components":[122],"peroxisomes.":[129],"They":[130],"each":[131,166],"interact":[132],"specifically":[133,181],"both":[136,146],"two-hybrid":[138],"analyses":[139],"vitro.":[142],"In":[143],"cells":[144],"lacking":[145],"Pex21p,":[149],"cytosolic":[152],"completely":[157],"abolished.":[158],"are":[162],"weakly":[163],"homologous":[164],"other":[167],"display":[169],"partial":[170],"functional":[171],"redundancy,":[172],"indicating":[173],"they":[175],"constitute":[176],"two-member":[178],"peroxin":[179],"family":[180],"targeting.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
