{"id":"https://openalex.org/W2014490323","doi":"https://doi.org/10.1097/qad.0b013e328356886d","title":"High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen","display_name":"High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen","publication_year":2012,"publication_date":"2012-06-27","ids":{"openalex":"https://openalex.org/W2014490323","doi":"https://doi.org/10.1097/qad.0b013e328356886d","mag":"2014490323","pmid":"https://pubmed.ncbi.nlm.nih.gov/22739389","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3757561"},"language":"en","primary_location":{"id":"doi:10.1097/qad.0b013e328356886d","doi":"https://doi.org/10.1097/qad.0b013e328356886d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0b013e328356886d","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3757561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075398862","display_name":"Henry Sunpath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121501","display_name":"McCord Hospital","ror":"https://ror.org/02p2egt14","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210121501"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Henry Sunpath","raw_affiliation_strings":["McCord Hospital, Durban, South Africa. henrysunpath@yebo.co.za","McCord Hospital, Durban, South Africa","Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","to Henry Sunpath, 45 McCord Road, Overport, 4001, South Africa. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McCord Hospital, Durban, South Africa. henrysunpath@yebo.co.za","institution_ids":["https://openalex.org/I4210121501"]},{"raw_affiliation_string":"McCord Hospital, Durban, South Africa","institution_ids":["https://openalex.org/I4210121501"]},{"raw_affiliation_string":"Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"to Henry Sunpath, 45 McCord Road, Overport, 4001, South Africa. E-mail: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018193139","display_name":"Baohua Wu","orcid":"https://orcid.org/0000-0003-0314-4272","observed_orcids":["https://orcid.org/0000-0003-0314-4272"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baohua Wu","raw_affiliation_strings":["Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074965128","display_name":"Michelle Lucille Gordon","orcid":"https://orcid.org/0000-0001-9945-1394","observed_orcids":["https://orcid.org/0000-0001-9945-1394"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Michelle Gordon","raw_affiliation_strings":["Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044721912","display_name":"Jane Hampton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121501","display_name":"McCord Hospital","ror":"https://ror.org/02p2egt14","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210121501"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Jane Hampton","raw_affiliation_strings":["McCord Hospital, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McCord Hospital, Durban, South Africa","institution_ids":["https://openalex.org/I4210121501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062529721","display_name":"Brent A. Johnson","orcid":"https://orcid.org/0000-0001-5665-8598","observed_orcids":["https://orcid.org/0000-0001-5665-8598"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent Johnson","raw_affiliation_strings":["Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035982137","display_name":"Mahomed\u2010Yunus S. Moosa","orcid":"https://orcid.org/0000-0001-6191-4023","observed_orcids":["https://orcid.org/0000-0001-6191-4023"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mahomed-Yunus S. Moosa","raw_affiliation_strings":["Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nelson Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090473117","display_name":"Claudia E. Ord\u00f3\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121501","display_name":"McCord Hospital","ror":"https://ror.org/02p2egt14","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210121501"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Claudia Ordonez","raw_affiliation_strings":["McCord Hospital, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McCord Hospital, Durban, South Africa","institution_ids":["https://openalex.org/I4210121501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058715015","display_name":"Daniel R. Kuritzkes","orcid":"https://orcid.org/0000-0001-6196-5883","observed_orcids":["https://orcid.org/0000-0001-6196-5883"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Kuritzkes","raw_affiliation_strings":["Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075575064","display_name":"Vincent C. Marconi","orcid":"https://orcid.org/0000-0001-8409-4689","observed_orcids":["https://orcid.org/0000-0001-8409-4689"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent C. Marconi","raw_affiliation_strings":["Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rollins School of Public Health, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075398862"],"corresponding_institution_ids":["https://openalex.org/I4210121501","https://openalex.org/I95023434"],"apc_list":null,"apc_paid":null,"fwci":11.4893,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.9907933,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"26","issue":"13","first_page":"1679","last_page":"1684"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.843999981880188},{"id":"https://openalex.org/keywords/k65r-mutation","display_name":"K65R mutation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tenofovir","display_name":"tenofovir","score":0.949999988079071},{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.8130000233650208},{"id":"https://openalex.org/keywords/antiretroviral-therapy-failure","display_name":"antiretroviral therapy failure","score":0.7480000257492065},{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.8859999775886536},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/stavudine","display_name":"stavudine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/transmitted-drug-resistance","display_name":"transmitted drug resistance","score":0.8659999966621399},{"id":"https://openalex.org/keywords/in-vivo-selection","display_name":"in vivo selection","score":0.4440000057220459},{"id":"https://openalex.org/keywords/genotypic-resistance-testing","display_name":"genotypic resistance testing","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.7701666355133057},{"id":"https://openalex.org/C2779889181","wikidata":"https://www.wikidata.org/wiki/Q423984","display_name":"Stavudine","level":5,"score":0.7217240333557129},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7174503803253174},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6685516834259033},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.645444929599762},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6283385753631592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6165634393692017},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.5773782730102539},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.5040749311447144},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4615919589996338},{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.4612409770488739},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4580726623535156},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4280202388763428},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.3090129494667053},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2564246654510498},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2523007392883301},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.23326534032821655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21697908639907837},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.20308947563171387},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.06910860538482666},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.04748764634132385},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068698","descriptor_name":"Tenofovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018119","descriptor_name":"Stavudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019259","descriptor_name":"Lamivudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/qad.0b013e328356886d","doi":"https://doi.org/10.1097/qad.0b013e328356886d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/qad.0b013e328356886d","pdf_url":null,"source":{"id":"https://openalex.org/S20605092","display_name":"AIDS","issn_l":"0269-9370","issn":["0269-9370","1473-5571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS","raw_type":"journal-article"},{"id":"pmid:22739389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22739389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AIDS (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2747405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3757561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3757561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3757561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AIDS","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2747405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3757561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1779889160","display_name":null,"funder_award_id":"U62/CCU123541-01","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G1818537372","display_name":"HIV-1 Therapeutics and Drug Resistance","funder_award_id":"K24RR016482","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000885469","display_name":"Center for AIDS Research at Emory University","funder_award_id":"P30AI050409","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000904381","display_name":"Harvard University Center for AIDS Research","funder_award_id":"P30AI060354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W173136499","https://openalex.org/W1976523151","https://openalex.org/W2015796602","https://openalex.org/W2021660989","https://openalex.org/W2022805318","https://openalex.org/W2041582591","https://openalex.org/W2092890561","https://openalex.org/W2102741140","https://openalex.org/W2121720236","https://openalex.org/W2140960318","https://openalex.org/W2143908311","https://openalex.org/W2143930204","https://openalex.org/W2152830821","https://openalex.org/W2162727299","https://openalex.org/W2169235930","https://openalex.org/W2172212187","https://openalex.org/W2415398231","https://openalex.org/W6606956595"],"related_works":["https://openalex.org/W1974444257","https://openalex.org/W1987571632","https://openalex.org/W2405137375","https://openalex.org/W1983772231","https://openalex.org/W2123884405","https://openalex.org/W2765487129","https://openalex.org/W250771843","https://openalex.org/W2042278201","https://openalex.org/W2148465801","https://openalex.org/W2111432534"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"sought":[2],"to":[3,128],"determine":[4],"the":[5,8,106,146,151,159,182,203,208],"rate":[6],"of":[7,76,115,134,142,145,194,202,219],"K65R":[9,152,209,220],"mutation":[10],"in":[11,51,101,105],"patients":[12,30,60,117,136,149,186,196,206,222],"receiving":[13],"tenofovir":[14],"(TDF)-based":[15],"antiretroviral":[16],"therapy":[17],"(ART)":[18],"with":[19,35,40,61,230,239],"subtype":[20,102,240],"C":[21],"HIV":[22,108],"infection.":[23],"DESIGN:":[24],"Retrospective":[25],"cohort":[26],"study.":[27],"METHODS:":[28],"All":[29,59],"initiated":[31,119,188],"on":[32,120,189,251],"stavudine":[33],"(d4T)":[34],"lamivudine":[36],"(3TC)":[37],"or":[38,255],"TDF":[39],"3TC":[41],"and":[42,140,168,200],"a":[43,66,77,88,252],"nonnucleoside":[44],"reverse":[45,234],"transcriptase":[46,235],"inhibitor":[47,236],"at":[48,171,227],"McCord":[49,228],"Hospital":[50,229],"Durban,":[52],"South":[53],"Africa":[54],"had":[55,81,137,150,197,207],"their":[56],"charts":[57],"reviewed.":[58],"virologic":[62,138,147,172,198,204],"failure,":[63],"defined":[64],"as":[65],"viral":[67,169],"load":[68,170],"more":[69],"than":[70],"1000":[71],"copies/ml":[72,177],"after":[73],"5":[74],"months":[75],"first":[78],"ART":[79,123],"regimen,":[80],"genotypic":[82],"resistance":[83,93],"testing":[84],"performed":[85],"prospectively":[86],"using":[87],"validated":[89],"in-house":[90],"assay.":[91],"Important":[92],"mutations":[94,100,237],"were":[95,118,187],"selected":[96],"based":[97],"upon":[98],"published":[99],"B":[103],"virus":[104],"Stanford":[107],"Drug":[109],"Resistance":[110],"database.":[111],"RESULTS:":[112],"A":[113],"total":[114],"585":[116],"TDF-containing":[121],"first-line":[122,225],"from":[124],"3":[125],"August":[126],"2010":[127],"17":[129],"March":[130],"2011.":[131],"Thirty-five":[132],"(6.0%)":[133],"these":[135,195],"failure":[139,148,173,199,205],"23":[141],"33":[143],"(69.7%)":[144],"mutation.":[153,210],"The":[154],"median":[155],"(interquartile":[156],"range)":[157],"for":[158,221],"baseline":[160],"CD4":[161],"cell":[162],"count":[163],"was":[164,174],"105":[165],"cells/\u03bcl":[166],"(49-209)":[167],"47":[175],"571":[176],"(20":[178],"708-202":[179],"000).":[180],"During":[181],"same":[183],"period,":[184],"53":[185],"d4T-containing":[190],"regimens.":[191],"Two":[192],"(3.8%)":[193],"one":[201],"CONCLUSION:":[211],"Preliminary":[212],"data":[213],"show":[214],"very":[215],"high":[216],"rates":[217,243],"(>65%)":[218],"failing":[223,253],"TDF-based":[224],"regimens":[226],"few":[231],"additional":[232],"nucleoside":[233],"compared":[238],"B.":[241],"These":[242],"may":[244],"reflect":[245],"faster":[246],"in-vivo":[247],"selection,":[248],"longer":[249],"time":[250],"regimen":[254],"transmitted":[256],"drug":[257],"resistance.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}