{"id":"https://openalex.org/W2014486472","doi":"https://doi.org/10.1016/0887-2333(93)90018-z","title":"Local lymph node assay: study of the in vitro proliferation and control of the specificity of the response by FACScan analysis","display_name":"Local lymph node assay: study of the in vitro proliferation and control of the specificity of the response by FACScan analysis","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2014486472","doi":"https://doi.org/10.1016/0887-2333(93)90018-z","mag":"2014486472","pmid":"https://pubmed.ncbi.nlm.nih.gov/20732205"},"language":"en","primary_location":{"id":"doi:10.1016/0887-2333(93)90018-z","doi":"https://doi.org/10.1016/0887-2333(93)90018-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0887-2333(93)90018-z","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040272700","display_name":"O. de Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. de Silva","raw_affiliation_strings":["Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M.J. Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M.J. Perez","raw_affiliation_strings":["Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068180240","display_name":"Nathalie Pineau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N. Pineau","raw_affiliation_strings":["Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111392023","display_name":"Andr\u00e9 Rougier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Rougier","raw_affiliation_strings":["Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070311333","display_name":"Koovi G. Dossou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14285755","display_name":"L'Or\u00e9al (France)","ror":"https://ror.org/00nb3j622","country_code":"FR","type":"company","lineage":["https://openalex.org/I14285755"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K.G. Dossou","raw_affiliation_strings":["Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires de Recherche Fondamentale de L'Oreal, 1 avenue Eug\u00e8ne Schueller, 93600 Aulnay-Sous-Bois, France","institution_ids":["https://openalex.org/I14285755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I14285755"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.9783,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.70918557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"7","issue":"4","first_page":"299","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/local-lymph-node-assay","display_name":"local lymph node assay","score":0.9980000257492065},{"id":"https://openalex.org/keywords/contact-allergens","display_name":"contact allergens","score":0.8009999990463257},{"id":"https://openalex.org/keywords/skin-irritants","display_name":"skin irritants","score":0.8790000081062317},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/dinitrochlorobenzene","display_name":"1-chloro-2,4-dinitrobenzene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymph-node-cell-proliferation","display_name":"lymph node cell proliferation","score":0.953000009059906},{"id":"https://openalex.org/keywords/cd3-t-cells","display_name":"CD3+ T cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/il-2-receptor","display_name":"interleukin-2 receptor","score":0.8339999914169312},{"id":"https://openalex.org/keywords/lymph-node-cellularity","display_name":"lymph node cellularity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C2780614586","wikidata":"https://www.wikidata.org/wiki/Q6664446","display_name":"Local lymph node assay","level":4,"score":0.9261343479156494},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.682654082775116},{"id":"https://openalex.org/C2777019933","wikidata":"https://www.wikidata.org/wiki/Q853845","display_name":"Fluorescein isothiocyanate","level":3,"score":0.6105071902275085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5826169848442078},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.5486723184585571},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5062004923820496},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5013024806976318},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46827268600463867},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4670274257659912},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.45847538113594055},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4215790331363678},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3352934718132019},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32457172870635986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3224380612373352},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29065871238708496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27829110622406006},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1824474334716797},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15399006009101868},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14953842759132385},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.08393266797065735},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.0},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/0887-2333(93)90018-z","doi":"https://doi.org/10.1016/0887-2333(93)90018-z","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0887-2333(93)90018-z","pdf_url":null,"source":{"id":"https://openalex.org/S39580544","display_name":"Toxicology in Vitro","issn_l":"0887-2333","issn":["0887-2333","1879-3177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in Vitro","raw_type":"journal-article"},{"id":"pmid:20732205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20732205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology in vitro : an international journal published in association with BIBRA","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1989770629","https://openalex.org/W1998852297","https://openalex.org/W2019786029","https://openalex.org/W2037466219","https://openalex.org/W2062508965","https://openalex.org/W2093374998","https://openalex.org/W2101186488","https://openalex.org/W2110313779","https://openalex.org/W2429127617","https://openalex.org/W6673660878"],"related_works":["https://openalex.org/W1974517736","https://openalex.org/W2047520262","https://openalex.org/W1990431802","https://openalex.org/W1979400631","https://openalex.org/W4237083830","https://openalex.org/W2117038888","https://openalex.org/W2110823300","https://openalex.org/W2406536359","https://openalex.org/W1989770629","https://openalex.org/W54278640"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}